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公开(公告)号:EP1493441A1
公开(公告)日:2005-01-05
申请号:EP03745958.3
申请日:2003-04-08
发明人: MATSUNAGA, Yugo, Zeria Pharmaceutical Co., Ltd. , UEKI, Shigeru, Zeria Pharmaceutical Co., Ltd. , HIGASHINO, Raita, Zeria Pharmaceutical Co., Ltd. , KAWACHI, Masanao, Zeria Pharmaceutical Co., Ltd. , KATO, Hiroki, Zeria Pharmaceutical Co., Ltd. , KOBAYASHI, Shiro, Zeria Pharmaceutical Co., Ltd.
IPC分类号: A61K31/426 , A61P1/00 , C07D277/56
CPC分类号: A61K31/426 , C07D277/56 , C07D307/68
摘要: A therapeutic agent for impaired gastric accommodation which contains as an active ingredient a compound represented by the general formula (1):
(wherein R 1 represents a hydrogen atom, a hydroxyl group or a halogen atom; A represents a furyl group, a thienyl group, a thiazolyl group or an oxazolyl group; R 2 and R 3 each represents an alkyl group with 1 to 5 carbon atoms; and n represents an integer of 2 to 4), or an acid addition salt thereof.
Use of a therapeutic agent of the present invention greatly alleviates symptoms caused by said disorders, such as early satiety and bloating, because it improves relaxation of gastric fundus and impaired gastric accommodation .-
公开(公告)号:EP1493441B1
公开(公告)日:2011-08-31
申请号:EP03745958.3
申请日:2003-04-08
发明人: MATSUNAGA, Yugo, Zeria Pharmaceutical Co., Ltd. , UEKI, Shigeru, Zeria Pharmaceutical Co., Ltd. , HIGASHINO, Raita, Zeria Pharmaceutical Co., Ltd. , KAWACHI, Masanao, Zeria Pharmaceutical Co., Ltd. , KATO, Hiroki, Zeria Pharmaceutical Co., Ltd. , KOBAYASHI, Shiro, Zeria Pharmaceutical Co., Ltd.
IPC分类号: A61K31/426 , A61P1/00 , C07D277/56 , A61K31/34 , A61K31/38 , A61K31/42
CPC分类号: A61K31/426 , C07D277/56 , C07D307/68
摘要: A therapeutic agent for food competence disorders in the stomach which contains as an active ingredient a compound represented by the general formula (1): (1) (wherein R1 represents hydrogen, hydroxy, or halogeno; A represents furyl, thienyl, thiazolyl, or oxazolyl; R2 and R3 each represents C1-5 alkyl; and n is an integer of 2 to 4) or an acid addition salt of the compound. This medicine functions to relax the gastric fundic part and alleviates food competence disorders in the stomach. It is hence effective in greatly alleviating symptoms caused by such disorders, such as early satiety and epigastric meteorism.
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