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公开(公告)号：EP1839662A1
公开(公告)日：2007-10-03
申请号：EP06711726.7
申请日：2006-01-16
IPC分类号： A61K31/551 , A61K45/00 , A61P35/00 , A61P35/02 , C07D243/12
CPC分类号： A61K31/551 , A61K9/0053 , A61K31/513 , A61K31/7068 , A61K45/06 , C07D243/12 , A61K2300/00
摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1) :
(wherein R 1 represents a C 1-6 alkyl group; R 2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C 1-4 alkylene group) or a pharmaceutically acceptable salt thereof.摘要翻译： 提供用于治疗和/或预防胃肠癌，白血病，垂体瘤，小细胞肺癌，甲状腺癌和神经星形细胞瘤的药剂或抗肿瘤剂。 （1）表示的1,5-苯并二氮杂衍生物作为有效成分的抗肿瘤剂：（式中，R1表示C1-6烷基，R2表示苯基或环己基，Y表示苯基或环己基，Y表示 单键或C1-4亚烷基）或其药学上可接受的盐。
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公开(公告)号：EP1839662B1
公开(公告)日：2010-03-24
申请号：EP06711726.7
申请日：2006-01-16
IPC分类号： A61K31/551 , A61K45/00 , A61P35/00 , A61P35/02 , C07D243/12
CPC分类号： A61K31/551 , A61K9/0053 , A61K31/513 , A61K31/7068 , A61K45/06 , C07D243/12 , A61K2300/00
摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1) : (wherein R 1 represents a C 1-6 alkyl group; R 2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C 1-4 alkylene group) or a pharmaceutically acceptable salt thereof.
摘要翻译： 一种抗肿瘤药物，一种用于治疗或预防消化系统癌症，白血病，垂体瘤，小细胞肺癌，甲状腺癌和神经星形细胞瘤的药物。 （1）表示的1,5-苯并二氮杂衍生物作为有效成分：（式中，R1表示C1-6烷基，R2表示苯基或环己基，Y表示单键或C1-4 亚烷基）或其药学上可接受的盐。
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