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公开(公告)号：EP0372484A2
公开(公告)日：1990-06-13
申请号：EP89122394.3
申请日：1989-12-05
发明人： Aotsuka, Tomoji , Torizuka, Motoki c/o Zeria Pharmaceutical Co.,Ltd. , Soeda, Mitsuo c/o Zeria Pharmaceutical Co.,Ltd. , Ogura, Kuniyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Tanaka, Yoshiaki c/o Zeria Pharmaceutical Co.,Ltd. , Kato, Hisayoshi c/o Zeria Pharmaceutical Co.,Ltd. , Nakata, Naoki c/o Zeria Pharmaceutical Co.,Ltd. , Miura, Naoyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Morita, Hikari c/o Zeria Pharmaceutical Co.,Ltd.
IPC分类号： C07D277/06 , A61K31/425 , C07D207/16 , A61K31/40 , C07D417/06 , C07D279/12 , C07D211/60 , C07K5/06
CPC分类号： C07D417/06 , C07D207/16 , C07D211/60 , C07D277/06 , C07D279/12 , C07K5/06165
摘要： Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I),
wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R¹ represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R² represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R³ represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.摘要翻译： 公开了具有脯氨酰内肽酶抑制，抗缺氧和抗遗忘活性的新型浓缩苯衍生物。 化合物由以下（I）表示，其中A表示亚甲基，亚乙基或亚丙基，B表示亚甲基或亚乙基，m表示0-5的整数，X和Y可以是 相同或不同，各自表示亚甲基或硫原子，R 1表示氢原子，羧基，低级烷氧基羰基，羟甲基或甲酰基，R 2表示氢原子，卤素原子，低级烷基 ，低级烷氧基，硝基或氨基，R 3表示氢原子或低级烷基，虚线可以任选存在。 它们可用作治疗或预防脑循环障碍，脑代谢障碍或记忆障碍的药物。
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公开(公告)号：EP0372484B1
公开(公告)日：1994-10-26
申请号：EP89122394.3
申请日：1989-12-05
发明人： Aotsuka, Tomoji , Torizuka, Motoki c/o Zeria Pharmaceutical Co.,Ltd. , Soeda, Mitsuo c/o Zeria Pharmaceutical Co.,Ltd. , Ogura, Kuniyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Tanaka, Yoshiaki c/o Zeria Pharmaceutical Co.,Ltd. , Kato, Hisayoshi c/o Zeria Pharmaceutical Co.,Ltd. , Nakata, Naoki c/o Zeria Pharmaceutical Co.,Ltd. , Miura, Naoyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Morita, Hikari c/o Zeria Pharmaceutical Co.,Ltd.
IPC分类号： C07D277/06 , A61K31/425 , C07D207/16 , A61K31/40 , C07D417/06 , C07D279/12 , C07D211/60 , C07K5/06
CPC分类号： C07D417/06 , C07D207/16 , C07D211/60 , C07D277/06 , C07D279/12 , C07K5/06165
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公开(公告)号：EP0372484A3
公开(公告)日：1991-02-27
申请号：EP89122394.3
申请日：1989-12-05
发明人： Aotsuka, Tomoji , Torizuka, Motoki c/o Zeria Pharmaceutical Co.,Ltd. , Soeda, Mitsuo c/o Zeria Pharmaceutical Co.,Ltd. , Ogura, Kuniyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Tanaka, Yoshiaki c/o Zeria Pharmaceutical Co.,Ltd. , Kato, Hisayoshi c/o Zeria Pharmaceutical Co.,Ltd. , Nakata, Naoki c/o Zeria Pharmaceutical Co.,Ltd. , Miura, Naoyoshi c/o Zeria Pharmaceutical Co.,Ltd. , Morita, Hikari c/o Zeria Pharmaceutical Co.,Ltd.
IPC分类号： C07D277/06 , A61K31/425 , C07D207/16 , A61K31/40 , C07D417/06 , C07D279/12 , C07D211/60 , C07K5/06
CPC分类号： C07D417/06 , C07D207/16 , C07D211/60 , C07D277/06 , C07D279/12 , C07K5/06165
摘要： Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I),
wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R¹ represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R² represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R³ represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.
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