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1.发明授权2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF 有权2，6-取代的嘌呤DISTICKSTOFFHALTIGE衍生物，其制备和用途
公开(公告)号：EP2149574B1
公开(公告)日：2015-12-02
申请号：EP08748397.0
申请日：2008-04-17
发明人： WU, Zhanggui , YE, Weidong , YUAN, Jianyong , CHEN, Gang
IPC分类号： C07D473/16 , C07H19/16 , C07H19/173 , C07H19/20 , A61K31/52 , A61K31/7076 , A61P35/00
CPC分类号： C07D473/16 , C07H19/16 , C07H19/173 , C07H19/20
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2.发明公开2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF 有权2，6-DISTICKSTOFFHALTIGE SUBSTITUIERTE PURINDERIVATE，IHRE ZUBEREITUNG UND VERWENDUNG
公开(公告)号：EP2149574A1
公开(公告)日：2010-02-03
申请号：EP08748397.0
申请日：2008-04-17
发明人： WU, Zhanggui , YE, Weidong , YUAN, Jianyong , CHEN, Gang
IPC分类号： C07D473/16 , C07H19/16 , C07H19/173 , C07H19/20 , A61K31/52 , A61K31/7076 , A61P35/00
CPC分类号： C07D473/16 , C07H19/16 , C07H19/173 , C07H19/20
摘要： The present invention provides 2, 6-dinitrogen-containing substituted purine compounds of formula (A) or salts or solvates thereof or the solvates of salts thereof, as well as pharmaceutical compositions containing such compounds. The compounds of the present invention have the characteristics of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds.
摘要翻译： 本发明提供了2,6-二氮杂的式（A）的取代的嘌呤化合物或其盐或溶剂合物或其盐的溶剂合物，以及含有这些化合物的药物组合物。 本发明的化合物具有毒性低，抗癌谱广，抗癌活性高，稳定性好等特点。 该化合物可用于制造抗肿瘤药物。 本发明还提供了制备这些化合物的方法。
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