专利检索 ipc:"C07H19/20" 第 1 页

1.

发明公开
DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开

公开(公告)号：EP4310194A3

公开(公告)日：2024-10-16

申请号：EP23212547.6

申请日：2008-10-17

申请人： The Trustees of Columbia University in the City of New York

发明人： JU, Jingyue , CAO, Huanyan , LI, Zengmin , MENG, Qinglin , GUO, Jia , ZHANG, Shenglong , YU, Lin

IPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q1/6876

摘要： This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

2.

发明公开
SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES 审中-实审

公开(公告)号：EP4370136A2

公开(公告)日：2024-05-22

申请号：EP22842917.1

申请日：2022-07-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah , MADAOUI, Mimouna , DATTA, Dhrubajyoti

IPC分类号： A61K31/7115 , A61K31/7088 , A61K31/712 , A61K31/7125 , C07H19/173 , C07H19/20 , C07H21/02

CPC分类号： C07H19/16 , C07H21/00 , C07H1/00 , C07H19/173 , C07H19/167

3.

发明授权
CRYSTALLINE FORMS OF ETHYL ((S)-((((2R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-FLUORO-2,5-DIHYDROFURAN-2-YL)OXY)METHYL)(PHENOXY)PHOSPHORYL)-L-ALANINATE (GS-9131) VANILLATE FOR TREATING VIRAL INFECTIONS 有权

公开(公告)号：EP3960740B1

公开(公告)日：2023-11-15

申请号：EP21186643.9

申请日：2018-07-30

发明人： LAPINA, Olga Viktorovna , SHI, Bing , WANG, Silas

IPC分类号： C07D417/12 , C07D473/34 , C07D493/04 , C07D498/14 , C07H19/16 , C07H19/20 , A61K31/5365 , A61K31/5377 , A61K31/635 , A61K31/675 , A61P31/18

4.

发明公开
COMPOUND FOR RNA CAPPING AND APPLICATION OF COMPOUND 审中-公开

公开(公告)号：EP4261217A1

公开(公告)日：2023-10-18

申请号：EP22917642.5

申请日：2022-09-22

申请人： Guangzhou Henovcom Bioscience Co., Ltd.

发明人： ZHANG, Jiancun , ZHANG, Lijun , ZHOU, Yiqian , CHEN, Jiafeng , ZHANG, Jufu , LI, Suyong , LIU, Yanhui , GUO, Chen , TANG, Wanjun , WU, Feng , HE, Xiaoxi , GUO, Qi , CHEN, Huixuan , WANG, Kun , LI, Deyao

IPC分类号： C07H19/20 , C07H1/00 , A61K31/7125 , C12N15/10 , C12P19/34

摘要： The present invention relates to compounds for RNA capping and uses thereof, which belong to the technical field of genetic engineering. Compounds of formula I can result in high levels of capping efficiency, and the capped mRNA exhibits increased expression.

5.

发明授权
MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF 有权

公开(公告)号：EP3399984B1

公开(公告)日：2023-09-06

申请号：EP17736459.3

申请日：2017-01-06

发明人： DEBIEN, Laurent, Pierre Paul , JAEN, Juan, Carlos , KALISIAK, Jaroslaw , LAWSON, Kenneth V. , LELETI, Manmohan Reddy , LINDSEY, Erick, Allen , MILES, Dillon Harding , NEWCOMB, Eric , POWERS, Jay Patrick , ROSEN, Brandon Reid , SHARIF, Ehesan UI

IPC分类号： A61K31/70 , C07H19/20 , C07H19/16 , A61K31/7076 , A61K31/7052 , C07D487/04

6.

发明授权
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF 有权

公开(公告)号：EP3013340B1

公开(公告)日：2023-06-07

申请号：EP14818480.7

申请日：2014-06-24

发明人： BEIGELMAN, Leonid , DEVAL, Jerome , JIN, Zhinan

IPC分类号： A61K31/4184 , A61K31/4192 , A61K31/675 , A61K31/506 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61P31/12 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/20

7.

发明授权
3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV 有权

公开(公告)号：EP3131914B1

公开(公告)日：2023-05-10

申请号：EP15719385.5

申请日：2015-04-16

发明人： ALEXANDRE, François-René , DUKHAN, David , DOUSSON, Cyril B. , GOSSELIN, Gilles , PAPARIN, Jean-Laurent , BRANDT, Guillaume , RAHALI, Rachid , SALANSON, Aurelien

IPC分类号： C07H19/10 , C07H19/11 , C07H19/20 , A61K31/7072 , A61K31/708 , A61P31/14

8.

发明公开
PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME 审中-公开

公开(公告)号：EP4121437A1

公开(公告)日：2023-01-25

申请号：EP21720054.2

申请日：2021-03-19

申请人： GILEAD SCIENCES, INC.

发明人： BYUN, Daniel H. , CHUN, Byoung-Kwon , CLARKE, Michael O. , JANSA, Petr , MACKMAN, Richard L. , NADUTHAMBI, Devan , SQUIRES, Neil H.

IPC分类号： C07H19/16 , C07H19/173 , C07H19/20 , C07H19/207 , A61P31/18

9.

发明公开
GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE 审中-公开

公开(公告)号：EP4092117A1

公开(公告)日：2022-11-23

申请号：EP21215891.9

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： BLEICHER, Konrad , DUSCHMALÉ, Joerg , DUSCHMALÉ, Martina Brigitte , HANSEN, Henrik Frydenlund , FUNDER, Erik , KOCH, Troels , LI, Meiling , SCHAEUBLIN, Adrian , SHU, Xi , WU, Yong

IPC分类号： C12N15/11 , C07F9/165 , C07H19/10 , C07H19/20 , C07H21/00

摘要： The present invention relates to a gapmer oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I)

as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.

10.

发明公开
FRET DYE LABELED REVERSIBLE NUCLEOTIDE TERMINATORS AND THEIR USE IN SEQUENCING OF DNA 审中-公开

公开(公告)号：EP4089098A1

公开(公告)日：2022-11-16

申请号：EP21172924.9

申请日：2021-05-10

申请人： Miltenyi Biotec B.V. & Co. KG

发明人： MARMA, Mong , GUAN, Xiao-Pei , SOLIMAN, Sameh , PERBOST, Michel

IPC分类号： C07H19/10 , C07H19/20 , C12Q1/68

摘要： The invention is directed to a deoxynucleotide triphosphate comprising a FRET energy transfer dye pair according to formula (I)

wherein B is a nucleobase
R is a reversible capping group
n is an integer from 1 to 10
CL is a chemically cleavable linker
D is a donor fluorescent dye
A is an acceptor dye
FL is a linker group

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