公开(公告)号：EP3459952A1

公开(公告)日：2019-03-27

申请号：EP17798784.9

申请日：2017-05-19

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

发明人： CHEN, Lei ,  GUAN, Dongliang ,  BAI, Hua ,  GOU, Jun ,  ZHAO, Weifeng ,  WANG, Zhongli ,  LING, Long ,  MA, Yutao

IPC分类号： C07D471/10 ,  C07D403/12 ,  C07D487/10 ,  A61K31/506 ,  A61P35/00

摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.

公开(公告)号：EP4215525A1

公开(公告)日：2023-07-26

申请号：EP21868671.5

申请日：2021-09-16

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd. ,  Shanghai Aryl Pharmtech Co., Ltd.

发明人： QIU, Haibo ,  MA, Yutao ,  CHEN, Ahuan ,  ZHU, Yabo ,  ZHANG, Binhao ,  LU, Yongping ,  YE, Cheng ,  HU, Taishan ,  QIAN, Wenjian ,  CHEN, Lei

IPC分类号： C07D403/10 ,  A61K31/4425 ,  A61P7/02

摘要： The present invention relates to a piperazine derivative, a preparation method therefor, and use thereof in medicine. Specifically, the present invention relates to a piperazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceutically acceptable salt or prodrug thereof, and use thereof as a therapeutic agent, in particular, as an inhibitor of coagulation factor XIa (FXIa), wherein the definition of each substituent in general formula (I) is the same as that in the description.

公开(公告)号：EP3998270A1

公开(公告)日：2022-05-18

申请号：EP20837650.9

申请日：2020-07-06

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd. ,  Hisun Accuray Therapeutics Co., Ltd.

发明人： LV, Hejun ,  MA, Yutao ,  QIU, Haibo ,  ZHAO, Wenwen ,  HU, Taishan ,  CHEN, Lei

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00 ,  A61P19/00 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  A61P11/06 ,  A61P35/02

摘要： The present invention relates to an alkyne derivative, a preparation method for same, and applications thereof in medicine. Specifically, the present invention relates to the alkyne derivative as represented by formula (I), the preparation method for same, a pharmaceutically acceptable salt thereof, and uses of them as a therapeutic agent, specifically as a phosphoinositide 3-kinase γ (PI3Kγ) inhibitor, where the definitions of the substituents in formula (I) are identical to the definitions in the description.