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公开(公告)号：EP4382527A1
公开(公告)日：2024-06-12
申请号：EP22852286.8
申请日：2022-08-04
发明人： GUO, Yanghui , MENG, Lichen , LIAO, Weiwei , ZHANG, Heng , WU, Chengfei , CHEN, Youxi , YE, Cheng , QIAN, Wenjian , CHEN, Lei , WU, Enguo
IPC分类号： C07D413/06 , C07D413/14 , A61K31/42 , A61K31/4439 , A61K31/506 , A61P31/04
CPC分类号： Y02A50/30 , A61K31/42 , A61K31/4439 , A61K31/506 , A61P31/04 , C07D413/14 , C07D413/06
摘要： Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description.
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2.发明公开
公开(公告)号：EP4177253A1
公开(公告)日：2023-05-10
申请号：EP21832154.5
申请日：2021-06-25
发明人： GUO, Yanghui , MENG, Lichen , HUANG, Xiangui , LIAO, Weiwei , GONG, Yongxiang , XU, Daiwang , HU, Taishan , CHEN, Lei
IPC分类号： C07D413/14 , A61K31/4725 , A61P25/04
摘要： The present invention relates to a pharmaceutically acceptable salt of ( S )-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tet rahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.
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公开(公告)号：EP4215525A1
公开(公告)日：2023-07-26
申请号：EP21868671.5
申请日：2021-09-16
发明人： QIU, Haibo , MA, Yutao , CHEN, Ahuan , ZHU, Yabo , ZHANG, Binhao , LU, Yongping , YE, Cheng , HU, Taishan , QIAN, Wenjian , CHEN, Lei
IPC分类号： C07D403/10 , A61K31/4425 , A61P7/02
摘要： The present invention relates to a piperazine derivative, a preparation method therefor, and use thereof in medicine. Specifically, the present invention relates to a piperazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceutically acceptable salt or prodrug thereof, and use thereof as a therapeutic agent, in particular, as an inhibitor of coagulation factor XIa (FXIa), wherein the definition of each substituent in general formula (I) is the same as that in the description.
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公开(公告)号：EP4092019A1
公开(公告)日：2022-11-23
申请号：EP21741490.3
申请日：2021-01-12
发明人： HUANG, Xiangui , GUO, Yanghui , QIU, Zongxing , BIE, Pingyan , LIAO, Weiwei , YAN, Qingyan , SHEN, Weichao , CAO, Hai , XING, Qingna , WANG, Xin , CAO, Qi , MENG, Lichen , WU, Nuoyi , LI, Wenpeng , YE, Cheng , HU, Taishan , CHEN, Lei
IPC分类号： C07D401/14 , C07D471/00 , C07D491/107 , C07D487/04 , C07D405/14 , C07D413/14 , C07D513/10 , C07D519/00 , A61K31/497 , A61K31/675 , A61K31/5377 , A61P35/00 , A61P9/00
摘要： The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in partucular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.
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公开(公告)号：EP3954680A1
公开(公告)日：2022-02-16
申请号：EP20786768.0
申请日：2020-04-09
发明人： ZHANG, Panpan , YAN, Sunli , LI, Ying , GUO, Chenli , QIAN, Wenjian , YE, Cheng , SHI, Zhengzheng , HU, Taishan , CHEN, Lei
IPC分类号： C07D401/14 , C07D403/04 , A61K31/506 , A61P35/00
摘要： The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , R 4 , R 4' , R 5 , R 5' , R 6 , R 6' , R 7 , R 7' , R 8 , m, and n have the same definitions as those in the specification.
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公开(公告)号：EP3459952A1
公开(公告)日：2019-03-27
申请号：EP17798784.9
申请日：2017-05-19
发明人： CHEN, Lei , GUAN, Dongliang , BAI, Hua , GOU, Jun , ZHAO, Weifeng , WANG, Zhongli , LING, Long , MA, Yutao
IPC分类号： C07D471/10 , C07D403/12 , C07D487/10 , A61K31/506 , A61P35/00
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：EP3339305A1
公开(公告)日：2018-06-27
申请号：EP16836680.5
申请日：2016-08-19
发明人： CHEN, Lei , GUAN, Dongliang , BAI, Hua , YAN, Xing , MIAO, Shuai , ZHU, Songsong
IPC分类号： C07D403/14 , A61K31/4184 , A61P35/00
CPC分类号： C07D403/14 , A61K31/4184 , A61P35/00 , C07D233/06 , C07D233/28 , C07D233/46 , C07D233/48 , C07D401/14
摘要： An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
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8.发明公开
公开(公告)号：EP4357340A1
公开(公告)日：2024-04-24
申请号：EP22824057.8
申请日：2022-06-01
发明人： ZHONG, Jinqing , ZHANG, Xinlong , GONG, Yongxiang , CHEN, Lei , ZHENG, Xiaohe , MAO, Lifei , LI, Yi
IPC分类号： C07D403/12 , C07C309/04 , C07C303/32 , A61K31/506 , A61P35/00
CPC分类号： C07C303/32 , A61P35/00 , A61K31/506 , C07D403/12 , C07C309/04
摘要： The present invention relates to a mesylate or ethanesulfonate salt of the compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the salt, and an application of the salt.
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公开(公告)号：EP3974434A1
公开(公告)日：2022-03-30
申请号：EP20809310.4
申请日：2020-05-20
发明人： CHEN, Youxi , GONG, Liang , ZHU, Xingwu , XIANG, Qing , MAO, Wentao , YE, Cheng , HU, Taishan , CHEN, Lei , JIANG, Guoping
IPC分类号： C07D498/22 , C07D487/22 , C07D487/18 , A61K31/529 , A61K45/06 , A61P29/00 , A61P35/00 , A61P25/00 , A61P37/00
摘要： Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,
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公开(公告)号：EP3998270A1
公开(公告)日：2022-05-18
申请号：EP20837650.9
申请日：2020-07-06
发明人： LV, Hejun , MA, Yutao , QIU, Haibo , ZHAO, Wenwen , HU, Taishan , CHEN, Lei
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61P35/00 , A61P19/00 , A61P11/00 , A61P29/00 , A61P37/00 , A61P11/06 , A61P35/02
摘要： The present invention relates to an alkyne derivative, a preparation method for same, and applications thereof in medicine. Specifically, the present invention relates to the alkyne derivative as represented by formula (I), the preparation method for same, a pharmaceutically acceptable salt thereof, and uses of them as a therapeutic agent, specifically as a phosphoinositide 3-kinase γ (PI3Kγ) inhibitor, where the definitions of the substituents in formula (I) are identical to the definitions in the description.
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