公开(公告)号：EP4382527A1

公开(公告)日：2024-06-12

申请号：EP22852286.8

申请日：2022-08-04

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd. ,  Shanghai Aryl Pharmtech Co., Ltd.

发明人： GUO, Yanghui ,  MENG, Lichen ,  LIAO, Weiwei ,  ZHANG, Heng ,  WU, Chengfei ,  CHEN, Youxi ,  YE, Cheng ,  QIAN, Wenjian ,  CHEN, Lei ,  WU, Enguo

IPC分类号： C07D413/06 ,  C07D413/14 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/04

CPC分类号： Y02A50/30 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/04 ,  C07D413/14 ,  C07D413/06

摘要： Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description.