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1.发明公开
公开(公告)号：EP4357340A1
公开(公告)日：2024-04-24
申请号：EP22824057.8
申请日：2022-06-01
发明人： ZHONG, Jinqing , ZHANG, Xinlong , GONG, Yongxiang , CHEN, Lei , ZHENG, Xiaohe , MAO, Lifei , LI, Yi
IPC分类号： C07D403/12 , C07C309/04 , C07C303/32 , A61K31/506 , A61P35/00
CPC分类号： C07C303/32 , A61P35/00 , A61K31/506 , C07D403/12 , C07C309/04
摘要： The present invention relates to a mesylate or ethanesulfonate salt of the compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the salt, and an application of the salt.
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公开(公告)号：EP3444253A1
公开(公告)日：2019-02-20
申请号：EP17781792.1
申请日：2017-03-28
发明人： ZHONG, Jinqing , ZHAO, Xuyang , BAI, Hua , GONG, Yongxiang , ZHANG, Xinlong , ZHU, Qifeng , LIU, Weiwei , ZHOU, Ya
IPC分类号： C07D491/056 , C07D491/113
摘要： Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.
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3.发明公开BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF 审中-公开BENZAMIDDERIVAT MIT ANTIKREBSWIRKUNG SOWIE HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP2636667A1
公开(公告)日：2013-09-11
申请号：EP11837396.8
申请日：2011-11-03
发明人： BAI, Hua , ZHAO, Xuyang , GONG, Yongxiang , ZHONG, Jinqing , ZHU, Qifeng , LIU, Xiaoyu , LIU, Lifei , ZHOU, Qixian
IPC分类号： C07C233/65 , C07C233/92 , C07C231/02 , C07C231/12 , C07C271/64 , C07C269/04 , C07C255/57 , C07C253/30 , A61K31/166 , A61K31/27 , A61K31/277 , A61P35/00 , A61P35/02
CPC分类号： C07C255/60 , C07C231/02 , C07C233/65 , C07C233/92 , C07C253/30 , C07C255/57 , C07C271/64 , C07D295/192
摘要： Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
摘要翻译： 提供式（I）所示的苯甲酰胺衍生物或其药学上可接受的盐及其制备用于治疗癌症的药物的制备方法和用途，其中式（I）的基团定义如说明书所述 。
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公开(公告)号：EP2636667B1
公开(公告)日：2019-01-09
申请号：EP11837396.8
申请日：2011-11-03
发明人： BAI, Hua , ZHAO, Xuyang , GONG, Yongxiang , ZHONG, Jinqing , ZHU, Qifeng , LIU, Xiaoyu , LIU, Lifei , ZHOU, Qixian
IPC分类号： C07C233/65 , C07C233/92 , C07C231/02 , C07C231/12 , C07C271/64 , C07C269/04 , C07C255/57 , C07C253/30 , A61K31/166 , A61K31/27 , A61K31/277 , A61P35/00 , A61P35/02 , C07D295/192
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公开(公告)号：EP2871184B1
公开(公告)日：2017-09-06
申请号：EP13813363.2
申请日：2013-07-03
发明人： BAI, Hua , ZHAO, Xuyang , ZHONG, Jinqing , GONG, Yongxiang , ZHU, Qifeng , LIU, Xiaoyu , ZHENG, Xiaohe , LIU, Lifei
IPC分类号： C07D491/056 , C07D491/113 , A61K31/435 , A61K31/4523 , A61P25/00
CPC分类号： C07D491/056 , A61K31/435 , A61K31/4523 , C07D401/06 , C07D491/04 , C07D491/113
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6.发明公开BENZODIOXOLE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF 有权BENZODIOXOLDERIVAT，VERFAHREN ZU SEINER HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP2871184A1
公开(公告)日：2015-05-13
申请号：EP13813363.2
申请日：2013-07-03
发明人： BAI, Hua , ZHAO, Xuyang , ZHONG, Jinqing , GONG, Yongxiang , ZHU, Qifeng , LIU, Xiaoyu , ZHENG, Xiaohe , LIU, Lifei
IPC分类号： C07D401/06 , C07D491/056 , A61K31/435 , A61K31/4523 , A61P25/00
CPC分类号： C07D491/056 , A61K31/435 , A61K31/4523 , C07D401/06 , C07D491/04 , C07D491/113
摘要： Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R 1 , R 2 and A of formula (I) can be seen in the description.
摘要翻译： 本发明提供新的苯并间二氧杂环戊烯衍生物及其制备方法。 由式（I）表示的这些化合物或其药学上可接受的盐具有乙酰胆碱酯酶抑制活性，因此可用于治疗或预防阿尔茨海默氏病。 在描述中可以看出式（I）的R 1，R 2和A的定义。
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