公开(公告)号：EP3348548A1

公开(公告)日：2018-07-18

申请号：EP16843639.2

申请日：2016-09-06

申请人： Zhejiang Huahai Pharmaceutical Co., Ltd ,  Shanghai Synergy Pharmaceutical Sciences Co., Ltd

发明人： GE, Jian ,  LI, Yunfei ,  ZHANG, Zhen ,  WANG, Yijin ,  WANG, Jiamiao ,  CHENG, Tao

IPC分类号： C07D239/91 ,  C07D217/24 ,  A61K31/517 ,  A61P9/00

CPC分类号： A61K31/5355 ,  A61K31/4418 ,  A61K31/517 ,  A61K31/519 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  C07D217/24 ,  C07D239/91

摘要： Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.