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公开(公告)号：EP3348548A1
公开(公告)日：2018-07-18
申请号：EP16843639.2
申请日：2016-09-06
发明人： GE, Jian , LI, Yunfei , ZHANG, Zhen , WANG, Yijin , WANG, Jiamiao , CHENG, Tao
IPC分类号： C07D239/91 , C07D217/24 , A61K31/517 , A61P9/00
CPC分类号： A61K31/5355 , A61K31/4418 , A61K31/517 , A61K31/519 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/28 , C07D217/24 , C07D239/91
摘要： Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.
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公开(公告)号：EP3950676A1
公开(公告)日：2022-02-09
申请号：EP20778681.5
申请日：2020-03-24
发明人： XU, Xin , CHEN, Jia , ZHANG, Zhen , ZHANG, Liming , WU, Qimei , JIANG, Qingyun , GUO, Fengying , ZHANG, Yuyun , YU, Hao , WANG, Ying , SUN, Kang , ZANG, Chengxu , QIN, Chenggang , ZHOU, Xiaobo , ZHANG, Xiaojuan , WANG, Yijin , XIA, Xiaoer , LI, Yunfei , GE, Jian
IPC分类号： C07D213/64 , C07D401/14 , C07D401/12 , C07D405/12 , A61K31/4412 , A61K31/4433 , A61K31/444 , A61P35/00 , A61P35/02
摘要： The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and /or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.
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3.发明公开
公开(公告)号：EP3686198A1
公开(公告)日：2020-07-29
申请号：EP18857198.8
申请日：2018-09-17
发明人： XU, Xin , ZHANG, Zhen , LI, Yunfei , ZHANG, Liming , GUO, Fengying , JIANG, Qingyun , LI, Dongsheng , ZHANG, Linli , SONG, Jinqian , LIU, Lei , LIU, Qiang , SU, Jing , WANG, Yijin , GE, Jian
IPC分类号： C07D405/12 , C07D405/14 , C07D405/04 , A61K31/444 , A61K31/4433 , A61P29/00
摘要： Disclosed are a class of µ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The µ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
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公开(公告)号：EP3950682A1
公开(公告)日：2022-02-09
申请号：EP20779835.6
申请日：2020-03-24
发明人： XU, Xin , CHEN, Jia , ZHANG, Zhen , ZHANG, Liming , WU, Qimei , JIANG, Qingyun , GUO, Fengying , ZHANG, Yuyun , YU, Hao , ZHANG, Xiaojuan , SUN, Kang , ZHOU, Xiaobo , ZANG, Chengxu , WANG, Yijin , XIA, Xiaoer , LI, Yunfei , GE, Jian
IPC分类号： C07D401/12 , C07D405/12 , C07D413/12 , C07D491/02 , C07D491/10 , A61K31/4412 , A61K31/444 , A61K31/5377 , A61P35/00
摘要： Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.
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5.发明公开
公开(公告)号：EP3939979A1
公开(公告)日：2022-01-19
申请号：EP20769246.8
申请日：2020-03-11
发明人： XU, Xin , CHEN, Jia , ZHANG, Zhen , WANG, Guan , ZHANG, Linli , LI, Qiang , XI, Chenghao , QU, Minkai , ZHANG, Xiaojuan , CHEN, Chunqiao , YANG, Fan , XIA, Xiaoer , WANG, Yijin , LI, Yunfei , GE, Jian
IPC分类号： C07D471/14 , A61K31/437 , A61P37/00 , A61P17/00 , A61P25/28 , A61P3/10 , A61P35/00
摘要： Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.
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公开(公告)号：EP3438099A1
公开(公告)日：2019-02-06
申请号：EP17773210.4
申请日：2017-03-28
发明人： GE, Jian , LI, Yunfei , WANG, Jiamiao , WANG, Yijin , XIA, Xiaoer , XU, Xin , ZHANG, Zhen , LIU, Lei , ZHANG, Xiaojuan , ZHANG, Liming , LI, Dongsheng
IPC分类号： C07D295/096 , C07C65/11 , C07C51/41 , A61K31/495 , A61P25/24 , A61P25/30 , A61P25/32 , A61P25/28 , A61P25/04 , A61P25/00 , A61P29/00
摘要： The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.
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