公开(公告)号：EP3194421A1

公开(公告)日：2017-07-26

申请号：EP15842388.9

申请日：2015-09-17

申请人： Zymeworks, Inc.

发明人： WINTERS, Geoffrey C. ,  RICH, James R. ,  GARNETT, Graham Albert Edwin ,  MANDEL, Alexander Laurence ,  HSIEH, Tom Han Hsiao ,  BOURQUE, Elyse Marie Josee ,  BARNSCHER, Stuart Daniel

IPC分类号： C07K7/02 ,  A61K38/05 ,  A61K47/50 ,  A61P35/00 ,  C07D207/08 ,  C07K5/027

CPC分类号： C07K16/2887 ,  A61K38/00 ,  A61K38/06 ,  A61K47/54 ,  A61K47/6813 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6867 ,  C07K5/0205 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/73

摘要： Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

摘要翻译： 公开了具有细胞毒性和/或抗有丝分裂活性的化合物。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。 还公开了具有以下结构的组合物：（T） - （L） - （D），其中（T）是靶向部分，（L）是任选的接头，和（D）是具有细胞毒性和/ 有丝分裂活动。

公开(公告)号：EP4029873A1

公开(公告)日：2022-07-20

申请号：EP21197673.3

申请日：2015-09-17

申请人： Zymeworks Inc.

发明人： WINTERS, Geoffrey C. ,  RICH, James R. ,  GARNETT, Graham Albert Edwin ,  MANDEL, Alexander Laurence ,  HSIEH, Tom Han Hsiao ,  BOURQUE, Elyse Marie Josee ,  BARNSCHER, Stuart Daniel

IPC分类号： C07K7/02 ,  A61K38/05 ,  A61K47/50 ,  A61P35/00 ,  C07D207/08 ,  C07K5/027 ,  C07D207/448

摘要： Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.