公开(公告)号：EP1891111A1

公开(公告)日：2008-02-27

申请号：EP06752420.7

申请日：2006-05-08

申请人： ZymoGenetics, Inc.

发明人： SIADAK, Anthony, W. ,  BILSBOROUGH, Janine ,  FLORKIEWICZ, Elin ,  HARAN, Aaron, C. ,  RENE, Shirley

IPC分类号： C07K16/24 ,  C07K14/54 ,  A61P17/00 ,  A61P17/04

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/885 ,  Y10S514/886

摘要： There is provided a monoclonal antibody wherein the monoclonal antibody is produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation selected from a first group consisting of: a) ATCC Patent Deposit Designation PTA-6815; b) ATCC Patent Deposit Designation PTA-6816; c) ATCC Patent Deposit Designation PTA-6871; d) ATCC Patent Deposit Designation PTA-6829; and e) ATCC Patent Deposit Designation PTA-6830; or wherein the monoclonal antibody is selected from a second group consisting of: a) ATCC Patent Deposit Designation PTA-6831; b) ATCC Patent Deposit Designation PTA-6872; c) ATCC Patent Deposit Designation PTA-6875; and d) ATCC Patent Deposit Designation PTA-6873; for use in treating a disease selected from the group consisting of prurigo nodularis; cutaneous T cell lymphoma; atopic dermatitis; contact dermatitis; drug-induced allergic reactions; skin-tropic viruses; viral associated pruritis; vitiligo; alopecia aerata; acne rosacea; acne vulgaris; and bullous pemphigoid.

摘要翻译： 提供单克隆抗体，其中单克隆抗体由保藏有美国典型培养物保藏中心的杂交瘤产生，所述杂交瘤具有选自以下的第一组的ATCC专利保藏名称：a）ATCC专利保藏名称PTA-6815; b）ATCC专利保藏号PTA-6816; c）ATCC专利保藏号PTA-6871; d）ATCC专利保藏号PTA-6829; 和e）ATCC专利保藏号PTA-6830; 或其中所述单克隆抗体选自由以下组成的第二组：a）ATCC专利保藏名称PTA-6831; b）ATCC专利保藏号PTA-6872; c）ATCC专利保藏名称PTA-6875; 和d）ATCC专利保藏号PTA-6873; 用于治疗选自结节性痒疹的疾病; 皮肤T细胞淋巴瘤; 特应性皮炎; 接触性皮炎; 药物引起的过敏反应; 皮肤热带病毒; 病毒性相关性瘙痒症 白癜风; 秃头症 痤疮性红斑痤疮 寻常痤疮 和大疱性类天疱疮。