Novel cytokine ZCYTOR17 ligand
    4.
    发明公开
    Novel cytokine ZCYTOR17 ligand 有权
    Zytokin配体zur Behandlung von Asthma和Atemwegsüberreaktivität

    公开(公告)号:EP1961811A1

    公开(公告)日:2008-08-27

    申请号:EP08102636.1

    申请日:2003-01-21

    摘要: There is provided the use of a polypeptide for the manufacture of a medicament for up-regulating IL-13RA2 gene expression in a mammal, wherein the polypeptide comprises a sequence of amino acid residues that is at least 90% identical to the sequence of amino acid residues of a polypeptide selected from: (a) a polypeptide comprising the amino acid sequence from residues 38 (Val) to 152 (Leu) as shown in SEQ ID NO:2; (b) a polypeptide comprising the amino acid sequence from residues 27 (Leu) to 164 (Thr) as shown in SEQ ID NO:2; (c) a polypeptide comprising the amino acid sequence from residues 24 (Ser) to 164 (Thr) as shown in SEQ ID NO:2; and (d) a polypeptide comprising the amino acid sequence from residues 1 (Met) to 164 (Thr) as shown in SEQ ID NO:2.

    摘要翻译: 提供多肽用于制备用于在哺乳动物中上调IL-13RA2基因表达的药物的用途,其中所述多肽包含与氨基酸序列至少90%相同的氨基酸残基序列 选自以下的多肽的残基:(a)包含如SEQ ID NO:2所示的残基38(Val)至152(Leu)的氨基酸序列的多肽; (b)如SEQ ID NO:2所示的包含残基27(Leu)至164(Thr))的氨基酸序列的多肽; (c)包含如SEQ ID NO:2所示的残基24(Ser)至164(Thr)的氨基酸序列的多肽; 和(d)包含如SEQ ID NO:2所示的残基1(Met)至164(Thr)的氨基酸序列的多肽。

    Novel cytokine ZCYTOR17 ligand
    6.
    发明公开
    Novel cytokine ZCYTOR17 ligand 有权
    Neuartiger Zytokin-ZCYTOR17-配体

    公开(公告)号:EP2230299A1

    公开(公告)日:2010-09-22

    申请号:EP10168189.8

    申请日:2003-01-21

    摘要: There is provided an antibody or antibody fragment which specifically binds to a portion of SEQ ID NO:2, wherein said portion consists of between 30 and 100 contiguous amino acids of SEQ ID NO:2, and wherein said portion contains amino acids selected from the group consisting of: (a) amino acid residues 54 to 59 of SEQ ID NO: 2; (b) amino acid residues 129 to 134 of SEQ ID NO: 2; (c) amino acid residues 53 to 58 of SEQ ID NO: 2; (d) amino acid residues 35 to 40 of SEQ ID NO: 2; (e) amino acid residues 33 to 38 of SEQ ID NO: 2; (f) amino acid residues 114 to 119 of SEQ ID NO: 2; (g) amino acid residues 101 to 105 of SEQ ID NO: 2; (h) amino acid residues 126 to 131 of SEQ ID NO: 2; (i) amino acid residues 113 to 118 of SEQ ID NO: 2; and (j) amino acid residues 158 to 162 of SEQ ID NO:2.

    摘要翻译: 提供了与SEQ ID NO:2的一部分特异性结合的抗体或抗体片段,其中所述部分由SEQ ID NO:2的30-100个连续氨基酸组成,并且其中所述部分含有选自 组成:(a)SEQ ID NO:2的氨基酸残基54至59; (b)SEQ ID NO:2的氨基酸残基129至134; (c)SEQ ID NO:2的氨基酸残基53至58; (d)SEQ ID NO:2的氨基酸残基35至40; (e)SEQ ID NO:2的氨基酸残基33至38; (f)SEQ ID NO:2的氨基酸残基114至119; (g)SEQ ID NO:2的氨基酸残基101至105; (h)SEQ ID NO:2的氨基酸残基126至131; (i)SEQ ID NO:2的氨基酸残基113至118; 和(j)SEQ ID NO:2的氨基酸残基158至162。