公开(公告)号：EP1857466A2

公开(公告)日：2007-11-21

申请号：EP07012370.8

申请日：2000-12-22

申请人： ZymoGenetics, Inc.

发明人： Foster, Donald C. ,  Xu, Wenfeng ,  Madden, Kare L. ,  Kelly, James D. ,  Sprecher, Cindy A. ,  Brandt, Cameron S. ,  Rixon, Mark W. ,  Presnell, Scott R. ,  Fox, Brian A.

IPC分类号： C07K14/715 ,  C12N15/62 ,  C12N15/09 ,  C07K16/00 ,  A61P17/06

CPC分类号： C07K14/7056 ,  A61K38/00 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白重链的恒定区融合。 轻链和重链通过二硫键连接。

公开(公告)号：EP1857466A3

公开(公告)日：2008-02-13

申请号：EP07012370.8

申请日：2000-12-22

申请人： ZymoGenetics, Inc.

发明人： Foster, Donald C. ,  Xu, Wenfeng ,  Madden, Kare L. ,  Kelly, James D. ,  Sprecher, Cindy A. ,  Brandt, Cameron S. ,  Rixon, Mark W. ,  Presnell, Scott R. ,  Fox, Brian A.

IPC分类号： C07K14/715 ,  C12N15/62 ,  C12N15/09 ,  C07K16/00 ,  A61P17/06

CPC分类号： C07K14/7056 ,  A61K38/00 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.