公开(公告)号：EP1924603A2

公开(公告)日：2008-05-28

申请号：EP06814491.4

申请日：2006-09-13

申请人： Zymogenetics, Inc.

发明人： THOMPSON, Penny, J. ,  SIADAK, Anthony, W. ,  NORIEGA, Claire, R. ,  FRANKLIN, Henry, R. ,  OGUZ, Secil ,  THOMPSON, Deborah, L. ,  TOPOUZIS, Stavros ,  FRUEBIS, Joachim ,  BRASEL, Kenneth ,  YAO, Yue

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61K39/395

CPC分类号： C07K14/4702 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/76

摘要： The present invention provides methods of using PROK2 and PROK1 antagonist, including monoclonal antibodies to treat inflammation, angiogenesis, and cancer.

公开(公告)号：EP1064356A2

公开(公告)日：2001-01-03

申请号：EP99912853.1

申请日：1999-03-23

申请人： ZymoGenetics, Inc.

发明人： DEISHER, Theresa, A. ,  HANSON, Birgit ,  MOORE, Emma, E. ,  ROBERTSON, Tamara, L. ,  THOMPSON, Deborah, L. ,  LUM, Karen, D.

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N5/10 ,  A61K35/34 ,  G01N33/50

CPC分类号： C12N5/0668 ,  A61K38/00 ,  C12N5/0657 ,  C12N2500/90

摘要： The invention provides cardiac-derived pluripotent stem cells, which on proliferation and differentiation can produce a variety of cell types including cardiocytes, fibroblasts, smooth muscle cells, skeletal muscle cells, keratinocytes, osteoblasts and chondrocytes. The cells can be used in methods of treating patients suffering from necrotic heart tissue. The stem cells proliferate and differentiate to produce cardiocytes replacing the necrotic tissue. The cells can also be used to screen compounds for activity in promoting proliferation and/or differentiation of cardiac-derived stem cells.