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公开(公告)号：EP1032665A1
公开(公告)日：2000-09-06
申请号：EP98956578.3
申请日：1998-11-04
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/47 , C07K2319/02
摘要： The present invention relates to polynucleotide and polypeptide molecules for z219c, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting various human disease states and chromosomal abnormalities. The present invention also includes antibodies to the z219c polypeptides.
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公开(公告)号：EP0931148A1
公开(公告)日：1999-07-28
申请号：EP97910128.0
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： DEISHER, Theresa, A. , CONKLIN, Darrell, C. , RAYMOND, Fenella, C. , BUKOWSKI, Thomas, R. , HOLDERMAN, Susan, D. , HANSEN, Brigit , SHEPPARD, Paul, O.
IPC分类号： C12N15 , A61K38 , A61P9 , A61P19 , A61P21 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12P21
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
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公开(公告)号：EP0931148B1
公开(公告)日：2006-03-01
申请号：EP97910128.4
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： DEISHER, Theresa, A. , CONKLIN, Darrell, C. , RAYMOND, Fenella, C. , BUKOWSKI, Thomas, R. , HOLDERMAN, Susan, D. , HANSEN, Brigit , SHEPPARD, Paul, O.
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
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公开(公告)号：EP1190059A1
公开(公告)日：2002-03-27
申请号：EP00945123.8
申请日：2000-06-30
申请人： ZymoGenetics, Inc.
摘要： The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.
摘要翻译： 本发明涉及与motilin具有同源性的新型肽片段的多核苷酸，多肽，肽，变体和用途。 新型多肽片段的mRNA的组织分布特异于胃，小肠和胰腺。 已经在肾和小肠中显示了肽片段的结合。 本发明还包括表达编码新型SGIP肽的cDNA的激动剂，拮抗剂，变体，抗体和宿主细胞。
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公开(公告)号：EP1144441A2
公开(公告)日：2001-10-17
申请号：EP99933873.4
申请日：1999-07-09
申请人： ZymoGenetics, Inc.
IPC分类号： C07K14/00
CPC分类号： C12N9/6489 , A61K38/00 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for zdint1, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint1 polypeptides.
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公开(公告)号：EP1278852A2
公开(公告)日：2003-01-29
申请号：EP01937280.4
申请日：2001-05-10
申请人： ZymoGenetics, Inc.
IPC分类号： C12N15/16 , C07K14/575
CPC分类号： C07K14/63
摘要： The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
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公开(公告)号：EP1144441A3
公开(公告)日：2001-11-28
申请号：EP99933873.4
申请日：1999-07-09
申请人： ZymoGenetics, Inc.
IPC分类号： C07K14/00
CPC分类号： C12N9/6489 , A61K38/00 , C07K2319/00
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公开(公告)号：EP1064356A2
公开(公告)日：2001-01-03
申请号：EP99912853.1
申请日：1999-03-23
申请人： ZymoGenetics, Inc.
发明人： DEISHER, Theresa, A. , HANSON, Birgit , MOORE, Emma, E. , ROBERTSON, Tamara, L. , THOMPSON, Deborah, L. , LUM, Karen, D.
CPC分类号： C12N5/0668 , A61K38/00 , C12N5/0657 , C12N2500/90
摘要： The invention provides cardiac-derived pluripotent stem cells, which on proliferation and differentiation can produce a variety of cell types including cardiocytes, fibroblasts, smooth muscle cells, skeletal muscle cells, keratinocytes, osteoblasts and chondrocytes. The cells can be used in methods of treating patients suffering from necrotic heart tissue. The stem cells proliferate and differentiate to produce cardiocytes replacing the necrotic tissue. The cells can also be used to screen compounds for activity in promoting proliferation and/or differentiation of cardiac-derived stem cells.
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公开(公告)号：EP0975760A1
公开(公告)日：2000-02-02
申请号：EP98911928.4
申请日：1998-03-23
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonsits, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
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10.发明授权
公开(公告)号：EP1232175B1
公开(公告)日：2009-07-08
申请号：EP00982197.6
申请日：2000-11-22
申请人： ZymoGenetics, Inc.
发明人： SHEPPARD, Paul, O. , JASPERS, Stephen, R. , DEISHER, Theresa, A. , BISHOP, Paul, D. , CONKLIN, Darrell C.
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
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