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公开(公告)号：EP2264175B1
公开(公告)日：2012-11-21
申请号：EP10176653.3
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
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2.发明公开
公开(公告)号：EP1323823A2
公开(公告)日：2003-07-02
申请号：EP03002314.7
申请日：1998-07-02
申请人： Zymogenetics Inc
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Antibodies, antibody fragments or single chain antibodies that specifically bind to human and mouse orthologs of the Zsig-9 secreted polypeptide are provided, the antibodies are preferably monoclonal. Also provided are methods of using the antibodies of the invention as well as in-vitro methods of diagnosing cancer in human tissues or body fluids utilising the antibodies of the invention or antisense nucleic acid sequences that specifically bind to Zsig-9 polynucleotide sequences. The invention is of particular use in diagnosing cancers such as brain tumour, liver tumour, lung tumour, esophageal tumour, stomach tumour, colon tumour, rectal tumour, thyroid tumour, or lymphoma tumour.
摘要翻译： 抗体，抗体片段或单链抗体并以设置在ZSIG-9分泌的多肽的人类和小鼠直系同源物特异性结合，所述抗体优选是单克隆的。 所以提供了使用本发明的抗体以及在体外在人组织或利用本发明或反义核酸序列的抗体体液诊断癌症的方法都特异性结合ZSIG-9的序列的多核苷酸的方法。 本发明是在诊断癌症特别有用的：如脑肿瘤，肝肿瘤，肺肿瘤，食管肿瘤，胃肿瘤，结肠肿瘤，直肠肿瘤，甲状腺瘤，或淋巴瘤肿瘤。
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公开(公告)号：EP1939293A2
公开(公告)日：2008-07-02
申请号：EP08100616.5
申请日：2001-06-29
申请人： ZymoGenetics, Inc.
发明人： Sheppard, Paul O. , Presnell, Scott R. , Fox, Brian A. , Gilbert, Teresa , Haldeman, Betty, A. , Grant, Francis J.
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The application provides a polypeptide comprising an amino acid sequence having at least 90% sequence identity to amino acid residues 20-200 of SEQ ID NO: 2, for treating multiple sclerosis, renal cell carcinoma, hepatitis B or hepatitis C.
摘要翻译： 本申请提供了包含与SEQ ID NO：2的氨基酸残基20-200至少90％序列同一性的氨基酸序列的多肽，用于治疗多发性硬化，肾细胞癌，乙型肝炎或丙型肝炎。
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公开(公告)号：EP1323823A3
公开(公告)日：2003-11-19
申请号：EP03002314.7
申请日：1998-07-02
申请人： Zymogenetics Inc
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Antibodies, antibody fragments or single chain antibodies that specifically bind to human and mouse orthologs of the Zsig-9 secreted polypeptide are provided, the antibodies are preferably monoclonal. Also provided are methods of using the antibodies of the invention as well as in-vitro methods of diagnosing cancer in human tissues or body fluids utilising the antibodies of the invention or antisense nucleic acid sequences that specifically bind to Zsig-9 polynucleotide sequences. The invention is of particular use in diagnosing cancers such as brain tumour, liver tumour, lung tumour, esophageal tumour, stomach tumour, colon tumour, rectal tumour, thyroid tumour, or lymphoma tumour.
摘要翻译： 提供了特异性结合Zsig-9分泌多肽的人和小鼠直向同源物的抗体，抗体片段或单链抗体，抗体优选为单克隆抗体。 还提供了使用本发明的抗体的方法以及利用本发明的抗体或特异性结合Zsig-9多核苷酸序列的反义核酸序列诊断人体组织或体液中的癌症的体外方法。 本发明特别用于诊断诸如脑瘤，肝肿瘤，肺肿瘤，食道肿瘤，胃肿瘤，结肠肿瘤，直肠肿瘤，甲状腺肿瘤或淋巴瘤肿瘤的癌症。
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公开(公告)号：EP2339002A1
公开(公告)日：2011-06-29
申请号：EP10185113.7
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： There is provided an isolated polynucleotide molecule encoding a fibroblast growth factor (FGF) homolog polypeptide selected from the group consisting of: a) a polynucleotide molecule comprising a nucleotide sequence as shown in SEQ ID. NO:1 from nucleotide 82 to nucleotide 621; b) allelic variants of (a); c) a polynucleotide molecule that encode a polypeptide that is at least 60% identical to the amino acid sequence of SEQ ID. NO:2 from amino acid residue 28 (Glu) to amino acid residue 207 (Ala); and d) a polynucleotide molecule comprising a nucleotide sequence as shown in SEQ ID. NO:6 from nucleotide 82 to nucleotide 621.
摘要翻译： 提供了编码选自以下的成纤维细胞生长因子（FGF）同源多肽的分离的多核苷酸分子：a）包含SEQ ID NO：1所示的核苷酸序列的多核苷酸分子。 NO：1从核苷酸82到核苷酸621; b）（a）的等位基因变体; c）编码与SEQ ID中氨基酸序列至少60％相同的多肽的多核苷酸分子。 从氨基酸残基28（Glu）到氨基酸残基207（Ala）的NO：2; 和d）包含SEQ ID NO：1所示的核苷酸序列的多核苷酸分子。 NO：6从核苷酸82到核苷酸621。
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公开(公告)号：EP1988102A1
公开(公告)日：2008-11-05
申请号：EP08075507.7
申请日：1999-12-07
申请人： ZymoGenetics, Inc.
发明人： Gao, Zeren , Hart, Charles E. , Piddington, Christopher S. , Sheppard, Paul O. , Shoemaker, Kimberly E. , Gilbertson, Debra G. , West, James W.
CPC分类号： C07K14/475 , A61K38/00 , C07K14/52
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白质和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：EP1927600A1
公开(公告)日：2008-06-04
申请号：EP08150287.4
申请日：2004-08-09
申请人： Zymogenetics, Inc.
发明人： Brady, Lowell J. , Klucher, Kevin M. , Chan, Chung , Dong, Dennis L. , Liu, Hong Y. , Sheppard, Paul O. , Bukowski, Thomas R.
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： The application provides a fusion protein comprising: (i) a polypeptide that comprises a sequence of amino acids residues selected from the group consisting of SEQ ID NOs: 83, 85, 87, 89, 95, 97, 103, 105, 111, 113, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159 and 161; and (ii) a polyalkyl oxide moiety.
摘要翻译： 本申请提供了融合蛋白，其包含：（i）包含选自SEQ ID NOs：83,85,87,89,95,97,103,105,111,113的氨基酸残基序列的多肽 ，139,141,143,145,147,149,151,153,155,157,159和161; 和（ii）多烷基氧化物部分。
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公开(公告)号：EP1632574A1
公开(公告)日：2006-03-08
申请号：EP05021714.0
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Holderman, Susan D. , Hansen, Brigit , Sheppard, Paul O.
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译： 本发明涉及用于zFGF-5（FGF家族的新成员）的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重建心脏组织和改善心脏功能。 本发明还包括对zFGF-5多肽的抗体。
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公开(公告)号：EP1382345A3
公开(公告)日：2004-01-28
申请号：EP03008817.3
申请日：2000-02-17
申请人： Zymogenetics Inc
CPC分类号： A61K38/1709
摘要： The invention provides uses for adipocyte complement related protein in the manufacture of pharmaceuticals for minimizing vascular occlusion, inducing vasodilation and enhancing the progression of wound healing in mammals. A preferred amino acid sequence for the adipocyte complement related protein is provided. The invention demonstrates particular utility in treating cases of vascular injury arising from surgery or trauma.
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公开(公告)号：EP1988102B1
公开(公告)日：2013-08-21
申请号：EP08075507.7
申请日：1999-12-07
申请人： ZymoGenetics, Inc.
发明人： Gao, Zeren , Hart, Charles E. , Piddington, Christopher S. , Sheppard, Paul O. , Shoemaker, Kimberly E. , Gilbertson, Debra G. , West, James W.
CPC分类号： C07K14/475 , A61K38/00 , C07K14/52
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