公开(公告)号：EP2962697A1

公开(公告)日：2016-01-06

申请号：EP15168204.4

申请日：2007-11-27

申请人： diaDexus, Inc.

发明人： Papkoff, Jackie ,  Diedrich, Gundo ,  Liu, Shu-Hui ,  Nowakowski, Agnes

IPC分类号： A61K39/395 ,  C07K16/46 ,  C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2827 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6823 ,  A61K47/6849 ,  A61K47/6855 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N9/96 ,  G01N33/57492 ,  A61K2300/00

摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

摘要翻译： 提供了针对Ovr10的分离的抗体及其抗原结合片段，其由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达。 还提供了用于其生产的细胞和方法及其用于杀死表达Ovr10的癌细胞并减轻或治疗哺乳动物中表达Ovr10的癌症的方法。 抗Ovr10抗体调节Ovr10功能或在体外和体内与哺乳动物细胞表达的Ovr1010结合时内化。 还提供了包含抗Ovr10抗体和载体的组合物及其制品或试剂盒。 此外，提供编码抗Ovr10抗体的分离的核酸，含有分离的核酸的表达载体和含有载体的宿主细胞。