公开(公告)号：EP1670787B1

公开(公告)日：2012-05-30

申请号：EP04809707.5

申请日：2004-09-10

申请人： iTherX Pharma, Inc.

发明人： BOMAN, Erik ,  CONDE-CEIDE, Susana ,  DAHL, Russell ,  DELAET, Nancy, G., J. ,  ERNST, Justin ,  MONTALBAN, Antonio, G. ,  KAHL, Jeffrey, D. ,  LARSON, Christopher ,  MILLER, Stephen ,  NAKANISHI, Hiroshi ,  ROBERTS, Edward ,  SAIAH, Eddine ,  SULLIVAN, Robert ,  WANG, Zhijun

IPC分类号： C07D231/40 ,  C07D239/47 ,  C07D249/12 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D295/088 ,  C07D253/075 ,  A61K31/416 ,  C07D207/40 ,  C07D231/12

CPC分类号： A61K31/416 ,  C07D207/40 ,  C07D231/12 ,  C07D231/40 ,  C07D239/47 ,  C07D249/12 ,  C07D253/075 ,  C07D295/088 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.