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    HETEROARYLACRYLOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM
    4.
    发明授权
    HETEROARYLACRYLOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 有权
    HETEROARYLACRYLOYLAMINOALKYL - 取代苯磺酰胺，生产，使用和药物组合物含有这些化合物

    公开(公告)号：EP1335902B1

    公开(公告)日：2008-10-08

    申请号：EP01992700.3

    申请日：2001-10-20

    申请人： Sanofi-Aventis Deutschland GmbH

    发明人： HEITSCH, Holger ,  ENGLERT, Heinrich, Christian

    IPC分类号： C07D213/56 ,  C07D333/24 ,  C07D411/12 ,  A61K31/381 ,  A61K31/4402 ,  A61P9/00

    CPC分类号： C07D409/12 ,  C07D213/56 ,  C07D333/24

    摘要： The present invention relates to heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives of the formula I, in which Het is 5-membered or 6-membered monocyclic heteroaryl having one or two identical or different ring heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, which is unsubstituted or is substituted by one or two identical or different substituents selected from the group consisting of halogen, nitro, (C1-C4)-alkyl, (C1-C4)-alkoxy and trifluoromethyl; R(1), R(2), R(3), R(4), X, Y and Z have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which have, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the vagal cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies, decreased contractility of the heart or vagal dysfunction of the heart, or for the prevention of sudden cardiac death. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical preparations comprising them.