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1.发明授权PIPERIDINESULFONYLUREAS AND -THIOUREAS, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权PIPERIDINSULFONYLHARNSTOFFE和硫脲，生产，使用和药物组合物含有它们
公开(公告)号：EP1828131B1
公开(公告)日：2008-06-04
申请号：EP05811326.7
申请日：2005-12-07
发明人： HACHTEL, Stephanie , ENGLERT, Heinrich, Christian , GERLACH, Uwe , GOEGELEIN, Heinz , HEITSCH, Holger , LEHR, Karl-Heinz , PFEIFFER-MAREK, Stefania
IPC分类号： C07D211/96 , A61K31/445
CPC分类号： C07D211/96
摘要： The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of the formula (I), in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of the formula (I) are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of the formula (I), their use and pharmaceutical compositions comprising them.
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2.发明授权FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION 有权稠合双环甲酰胺FOR USE AS CXCR2抑制剂在炎症的治疗
公开(公告)号：EP1836158B1
公开(公告)日：2012-02-01
申请号：EP05818685.9
申请日：2005-12-17
发明人： HACHTEL, Stephanie , DEDIO, Juergen , HEITSCH, Holger , CZECHTIZKY, Werngard , GRUENEBERG, Sven , SHIMSHOCK, Stephen sanofi-aventis US Inc. , KOSLEY, Raymond, W. , LANTER, Carolina , LI, Hui sanofi-aventis US Inc. , SHER, Rosy , WEICHSEL, Aleksandra
IPC分类号： C07C235/66 , C07D319/20 , C07D261/08 , C07D271/12 , C07D215/14 , C07D249/18 , C07D277/64 , C07D231/12 , C07D207/32 , C07D249/08 , C07D263/32 , C07D213/30 , C07D249/06 , C07D213/68 , C07D213/69
CPC分类号： C07D213/68 , C07D207/325 , C07D213/30 , C07D213/65 , C07D213/69 , C07D215/14 , C07D217/26 , C07D231/12 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/18 , C07D261/08 , C07D263/32 , C07D271/12 , C07D277/24 , C07D277/64 , C07D307/42 , C07D317/54 , C07D319/20 , C07D333/56 , C07D333/70 , C07D409/12 , C07D417/12 , C07D495/04
摘要： The invention relates to compounds of the formula (I) in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases such as inflammatory diseases.
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