公开(公告)号：EP0973513A1

公开(公告)日：2000-01-26

申请号：EP97912787.5

申请日：1997-10-23

申请人： zymogenetics, Inc. ,  Osteoscreen, Inc. ,  University of Texas Austin

发明人： ORME, Mark, W. ,  BAINDUR, Nand ,  ROBBINS, Kirk, G. ,  HARRIS, Scott, M. ,  KONTOYIANNI, Maria ,  HURLEY, Laurence, H. ,  KERWIN, Sean, M. ,  MUNDY, Gregory, R. ,  PETRIE, Charles

IPC分类号： A61K31/165 ,  A61K31/215 ,  A61K31/33 ,  A61K31/405 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/53

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：EP0866710A1

公开(公告)日：1998-09-30

申请号：EP96936906.0

申请日：1996-10-23

申请人： ZymoGenetics, Inc. ,  Osteoscreen, Inc. ,  University Of Texas At Austin

发明人： PETRIE, Charles ,  ORME, Mark, W. ,  BAINDUR, Nand ,  ROBBINS, Kirk, G. ,  HARRIS, Scott, M. ,  KONTOYIANNI, Maria ,  HURLEY, Laurence, H. ,  KERWIN, Sean, M. ,  MUNDY, Gregory, R.

IPC分类号： C07D285 ,  A61K31

CPC分类号： A61K31/549 ,  A61K31/47

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：EP0975589A2

公开(公告)日：2000-02-02

申请号：EP99902386.4

申请日：1999-01-20

申请人： ZymoGenetics, Inc. ,  Trega Biosciences, Inc.

发明人： PETRIE, Charles ,  MCKERNAN, Patricia, A. ,  MOORE, Emma, E. ,  OSTRECH, John, M. ,  MEYER, Jean-Philippe ,  HOUGHTEN, Richard, A. ,  PINELLA, Clemencia

IPC分类号： C07C275/00

CPC分类号： C07C275/28 ,  C07D209/20 ,  Y10S514/878

摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.

摘要翻译： 描述了起降钙素模拟物作用的二烷基脲化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物也可用于测定降钙素受体活性。

公开(公告)号：EP0968200A1

公开(公告)日：2000-01-05

申请号：EP98906624.6

申请日：1998-02-23

申请人： ZymoGenetics, Inc.

发明人： BAINDUR, Nand ,  LABROO, Virender ,  STROOP, Steven ,  BEIGEL, Stephanie ,  MARTINEZ, Theresa ,  PETRIE, Charles ,  ORME, Mark, W. ,  MCKERNAN, Patricia, A. ,  MOORE, Emma, E.

IPC分类号： C07D295/08 ,  C07D295/18 ,  A61K31/495

CPC分类号： C07D295/096 ,  A61K31/495 ,  C07D295/215

摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.