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公开(公告)号：EP0968200A1
公开(公告)日：2000-01-05
申请号：EP98906624.6
申请日：1998-02-23
申请人： ZymoGenetics, Inc.
发明人： BAINDUR, Nand , LABROO, Virender , STROOP, Steven , BEIGEL, Stephanie , MARTINEZ, Theresa , PETRIE, Charles , ORME, Mark, W. , MCKERNAN, Patricia, A. , MOORE, Emma, E.
IPC分类号： C07D295/08 , C07D295/18 , A61K31/495
CPC分类号： C07D295/096 , A61K31/495 , C07D295/215
摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
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公开(公告)号：EP0977861B1
公开(公告)日：2004-06-23
申请号：EP98918640.8
申请日：1998-04-23
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , GILBERT, Teresa , WHITMORE, Theodore, E. , FOSTER, Donald, C. , HART, Charles, E. , LEHNER, Joyce, M. , MARTINEZ, Theresa , HOFFMANN, Ross, C.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C07K19/00 , C07K16/24 , C07K16/42 , C12Q1/66 , C12Q1/68 , G01N33/52 , G01N33/60
CPC分类号： C07K14/52 , C07K2319/00 , C07K2319/02
摘要： Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
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公开(公告)号：EP0944312B1
公开(公告)日：2005-12-07
申请号：EP97954120.8
申请日：1997-12-12
申请人： ZymoGenetics, Inc.
发明人： GASPER, Shirley, R. , WEST, Robert, R. , MARTINEZ, Theresa , BAINDUR, Nand , ROBBINS, Kirk, G. , LABROO, Virender, M. , MCKERNAN, Patricia, A.
IPC分类号： A61K31/365 , A61K31/405
CPC分类号： A61K31/405 , A61K31/22 , A61K31/366 , A61K31/404
摘要： Compounds of formulas (1) and (2), wherein the variables of X, Y and R' are herein defined in the specification, promote bone information and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. The figure shows the structure and activity of several compounds of the invention namely, nevastatin, lovastatin and pravastatin, as tested in the in vitro BMP-promoter based assay.
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公开(公告)号：EP0977861A1
公开(公告)日：2000-02-09
申请号：EP98918640.8
申请日：1998-04-23
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , GILBERT, Teresa , WHITMORE, Theodore, E. , FOSTER, Donald, C. , HART, Charles, E. , LEHNER, Joyce, M. , MARTINEZ, Theresa , HOFFMANN, Ross, C.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C07K19/00 , C07K16/24 , C07K16/42 , C12Q1/66 , C12Q1/68 , G01N33/52 , G01N33/60
CPC分类号： C07K14/52 , C07K2319/00 , C07K2319/02
摘要： Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
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5.发明授权USE OF BREFELDIN A AND DERIVATIVES THEREOF IN THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF HYPERPLASIA AND RELATED DISORDERS 失效衍生物和用于治疗药物的生产及其布雷菲德菌素A的使用及相关疾病增生
公开(公告)号：EP0831807B1
公开(公告)日：2005-12-21
申请号：EP96918159.3
申请日：1996-06-04
申请人： ZymoGenetics, Inc.
IPC分类号： A61K31/365 , A61K31/23 , A61K31/715
CPC分类号： A61K31/19 , A61K31/365
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefelding A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists Brefeldin A and its derivatives may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.
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6.发明公开USE OF BREFELDIN A AND DERIVATIVES THEREOF IN THE TREATMENT OF HYPERPLASIA AND RELATED DISORDERS 失效衍生物和用于治疗药物的生产及其布雷菲德菌素A的使用及相关疾病增生
公开(公告)号：EP0831807A1
公开(公告)日：1998-04-01
申请号：EP96918159.0
申请日：1996-06-04
申请人： ZymoGenetics, Inc.
CPC分类号： A61K31/19 , A61K31/365
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefelding A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists Brefeldin A and its derivatives may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.
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公开(公告)号：EP0944312B9
公开(公告)日：2006-07-05
申请号：EP97954120.8
申请日：1997-12-12
申请人： ZymoGenetics, Inc.
发明人： GASPER, Shirley, R. , WEST, Robert, R. , MARTINEZ, Theresa , BAINDUR, Nand , ROBBINS, Kirk, G. , LABROO, Virender, M. , MCKERNAN, Patricia, A.
IPC分类号： A61K31/365 , A61K31/405
CPC分类号： A61K31/405 , A61K31/22 , A61K31/366 , A61K31/404
摘要： Compounds of formulas (1) and (2), wherein the variables of X, Y and R' are herein defined in the specification, promote bone information and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. The figure shows the structure and activity of several compounds of the invention namely, nevastatin, lovastatin and pravastatin, as tested in the in vitro BMP-promoter based assay.
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