公开(公告)号：EP1791847A2

公开(公告)日：2007-06-06

申请号：EP05787333.3

申请日：2005-09-05

申请人： Altana Pharma AG

发明人： FLOCKERZI, Dieter ,  KAUTZ, Ulrich ,  HATZELMANN, Armin ,  ZITT, Christof ,  WOHLSEN, Andrea ,  MARX, Degenhard ,  KLEY, Hans-Peter ,  CHRISTOFFERS, Jens ,  ROSIAK, Anna

IPC分类号： C07D498/06

CPC分类号： C07D495/04

摘要： Compounds of a certain formula 1, in which A, R1, R2 and R3 have the meanings indicated in the de- scription, are novel effective PDE4 inhibitors.

摘要翻译： 其中A，R1，R2和R3具有说明中所示含义的某些式1化合物是新型有效的PDE4抑制剂。

公开(公告)号：EP1791538A1

公开(公告)日：2007-06-06

申请号：EP05787069.3

申请日：2005-09-08

申请人： Altana Pharma AG

发明人： SHAH, Tushar, P. ,  SANJAR, Shahin ,  WEIR, Pamela

IPC分类号： A61K31/44

CPC分类号： A61K9/0075 ,  A61K9/0043 ,  A61K9/2018 ,  A61K31/4409 ,  A61K45/06 ,  A61K2300/00

摘要： This invention relates to pharmaceutical formulations containing combinations of roflumilast and a syk inhibitor and the use of such pharmaceutical compositions in medicine, in particular in the prophylaxis and treatment of respiratory disease.

公开(公告)号：EP1776361A1

公开(公告)日：2007-04-25

申请号：EP05780321.5

申请日：2005-07-29

申请人： Altana Pharma AG

发明人： PALMER, Andreas ,  BUHR, Wilm ,  ZIMMERMANN, Peter Jan ,  BREHM, Christof ,  CHIESA, M. Vittoria ,  GRUNDLER, Gerhard ,  SIMON, Wolfgang-Alexander ,  KROMER, Wolfgang ,  POSTIUS, Stefan

IPC分类号： C07D471/04 ,  A61K31/495

CPC分类号： C07D471/04

摘要： The invention relates to compounds of the formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric acid secretion inhibiting and excellent gastric and intestinal protective action properties.

公开(公告)号：EP1756118A1

公开(公告)日：2007-02-28

申请号：EP05750033.2

申请日：2005-06-03

申请人： Altana Pharma AG

发明人： PEKARI, Klaus ,  BAER, Thomas ,  SCHMIDT, Mathias ,  BECKERS, Thomas ,  BARTELS, Björn ,  GIMMNICH, Petra

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P35/00

CPC分类号： C07D495/04

摘要： Compounds of formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

摘要翻译： 其中R a和R b具有说明书中所示含义的式（I）化合物是具有抗增殖和/或编程性细胞死亡诱导活性的新型有效化合物。

公开(公告)号：EP0566601B2

公开(公告)日：2007-02-21

申请号：EP92901804.2

申请日：1992-01-04

申请人： ALTANA Pharma AG

发明人： BELLER, Klaus-Dieter ,  LINDER, Rudolf

IPC分类号： A61K49/00

CPC分类号： A61K49/223 ,  A61K49/227

公开(公告)号：EP1740188A1

公开(公告)日：2007-01-10

申请号：EP05742781.7

申请日：2005-04-19

申请人： Altana Pharma AG

发明人： WURST, Wilhelm ,  BETHKE, Thomas ,  ENGELSTAETTER, Renate

IPC分类号： A61K31/58 ,  A61P11/00 ,  A61P11/06

CPC分类号： A61K31/58 ,  A61K9/008

摘要： This invention relates to a new method of treatment of respiratory diseases, in particular the treatment of asthmatic smoking patients. The method comprisese the administration of a pharmaceutical composition comprising ciclesonide.

公开(公告)号：EP1735318A2

公开(公告)日：2006-12-27

申请号：EP05717076.3

申请日：2005-03-16

申请人： Altana Pharma AG

发明人： PALMER, Andreas ,  BUHR, Wilm ,  CHIESA, M. Vittoria ,  ZIMMERMANN, Peter Jan ,  BREHM, Christof ,  SIMON, Wolfgang-Alexander ,  KROMER, Wolfgang ,  POSTIUS, Stefan

IPC分类号： C07D491/14 ,  A61K31/437

CPC分类号： C07D491/14

摘要： The invention provides compounds of the formula (1), in which R1 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy-1-­4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-l-4C-alkyl or hydroxy-1-4C­alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl.-1-4C-alkyl, 1-4C-alkoxycarbonyl, hy­droxy-1-4C-alkyl, hydroxy-3-4-C-alkenyl, hydroxy-3-4C-alkinyl, halogen, 2-4C-alkenyl, 2-4C­alkynyl, fluoro-1-4C-alkyl, cyanomethyl, hydroxy, 1-4C-alkoxy, amino, mono- or di-1-4C­alkylamino, 1-4C-alkylcarbonylamino, 1-4C-alkoxycarbonylamino, 1-4C-alkoxy-1-4C­alkoxycarbonylamino, carboxyl, mono- or di-1-4C-alkylamino-1-4C-alkyl, 1-4C-alkylcarbonyl, 2­4C-alkenylcarbonyl, 2-4C-alkinylcarbonyl or the radical -CO-NR21R22, R3 is 1-4C-alkylcarbonyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkoxy-l­4C-alkyl, 1-4C-alkoxycarbonyl, fluoro-1-4C-alkoxy-1-4C-alkyl, cyano, the radical -CO-NR31R32, the radical -S02-NR31 R32, the radical -CS-NR31 R32, the radical -C=N(OH)-NR1 R32 or the group Het. Arom is a R4-, R5-, R6- and R7-substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimida­zolyl, furanyl (furyl), benzofuranyl (benzofuryl), thiophenyl (thienyl), benzothiophenyl (ben­zothienyl), thiazolyl, isoxazolyl, pyridinyl, pyrimidinyi, quinolinyl and isoquinolinyl. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1539164B1

公开(公告)日：2006-12-20

申请号：EP03790931.4

申请日：2003-08-28

申请人： ALTANA Pharma AG

发明人： KAUTZ, Ulrich ,  SCHMIDT, Beate ,  FLOCKERZI, Dieter ,  GRUNDLER, Gerhard ,  NAVE, Rüdiger ,  HUMMEL, Rolf-Peter ,  STURM, Ernst ,  HATZELMANN, Armin ,  BARSIG, Johannes ,  MARX, Degenhard ,  KLEY, Hans-PETER

IPC分类号： A61K31/473 ,  C07D221/12 ,  A61P11/08

CPC分类号： C07D221/12

摘要： Compounds of a certain formula I, in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings indicated in the desription, are novel effective PDE4 inhibitors.

公开(公告)号：EP1725532A1

公开(公告)日：2006-11-29

申请号：EP05716950.0

申请日：2005-03-08

申请人： Altana Pharma AG

发明人： KAUTZ, Ulrich ,  SCHMIDT, Beate ,  FLOCKERZI, Dieter ,  HATZELMANN, Armin ,  ZITT, Christof ,  BARSIG, Johannes ,  MARX, Degenhard ,  KLEY, Hans-Peter

IPC分类号： C07D221/12 ,  A61K31/473

CPC分类号： C07D221/12

摘要： Compounds of a certain formula (I), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.

摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 6和R 7具有说明书中所示含义的某些式（I）化合物是新的有效PDE4抑制剂。

公开(公告)号：EP1725528A2

公开(公告)日：2006-11-29

申请号：EP05716989.8

申请日：2005-03-10

申请人： Altana Pharma AG

发明人： MAIER, Thomas ,  BECKERS, Thomas ,  BAER, Thomas ,  GIMMNICH, Petra ,  DULLWEBER, Frank ,  VENNEMANN, Matthias

IPC分类号： C07D207/48

CPC分类号： A61K31/40 ,  C07D207/48 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

摘要： Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.