公开(公告)号：EP1648418A2

公开(公告)日：2006-04-26

申请号：EP04778631.4

申请日：2004-07-20

申请人： Advancis Pharmaceutical Corporation

发明人： BURNSIDE, Beth, A. ,  FLANNER, Henry, H. ,  ROWLINGS, Colin

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54

CPC分类号： A61K9/4808 ,  A61K9/2077

摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型以及两种或更多种持续释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。

公开(公告)号：EP1465591A1

公开(公告)日：2004-10-13

申请号：EP02794328.1

申请日：2002-12-20

申请人： Advancis Pharmaceutical Corporation

发明人： RUDNIC, Edward, M. ,  ISBISTER, James, D. ,  TREACY, Donald, J., Jr. ,  WASSINK, Sandra, E.

IPC分类号： A61K9/00 ,  A61K9/48 ,  A61K9/52 ,  A61K9/54 ,  A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K9/14

CPC分类号： A61K9/5084 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5026 ,  A61K31/00 ,  A61K31/4164 ,  A61K31/43 ,  A61K45/06 ,  A61K2300/00

摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

公开(公告)号：EP1701705A2

公开(公告)日：2006-09-20

申请号：EP04815260.7

申请日：2004-12-23

申请人： Advancis Pharmaceutical Corporation

发明人： TREACY, Donald, J., Jr. ,  FLANNER, Henry, H. ,  GUTTENDORF, Robert ,  BURNSIDE, Beth

IPC分类号： A61K9/20 ,  A61K9/48

CPC分类号： A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/5073 ,  A61K31/43

摘要： Disclosed are products and methods for improving the plasma profile in a patient being treated with a pharmaceutical active agent that is subject to a limited window of absorption, which products and methods comprise orally administering the active agent in multiparticulate form, such that at least a portion thereof is delivered to the intestine while the patient is in the fed condition.

公开(公告)号：EP1653925A1

公开(公告)日：2006-05-10

申请号：EP04780995.9

申请日：2004-08-11

申请人： Advancis Pharmaceutical Corporation

发明人： CAO, Bruce, X. ,  BURNSIDE, Beth, A. ,  WASSINK, Sandra, E. ,  BAKER, Matt, R.

IPC分类号： A61K9/14

CPC分类号： A61K9/1617 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K31/43 ,  C07D499/00

摘要： Compositions and methods for making robust pellets that contain a high percentage, by weight, of active drug agent, and which also contain additional components that enhance the absorption and solubility of the active drug agent within the gastrointestinal tract (GI tract) without diminishing the robust nature of the pellet, are disclosed.

公开(公告)号：EP1648415A2

公开(公告)日：2006-04-26

申请号：EP04757155.9

申请日：2004-07-20

申请人： Advancis Pharmaceutical Corporation

发明人： BURNSIDE, Beth, A. ,  FLANNER, Henry, H. ,  ROWLINGS, Colin

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54

CPC分类号： A61K9/5084 ,  A61K9/2077 ,  A61K9/4808

摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, a delayed release dosage form, and a sustained release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型，延迟释放剂型和持续释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。

公开(公告)号：EP1542656A1

公开(公告)日：2005-06-22

申请号：EP03767085.8

申请日：2003-08-01

申请人： Advancis Pharmaceutical Corporation

发明人： RUDNIC, Edward, M. ,  ISBISTER, James, D. ,  TREACY, Donald, J., Jr. ,  WASSINK, Sandra, E.

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/14 ,  A61K9/54

CPC分类号： A61K9/2081 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5084 ,  A61K31/00 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/7048 ,  A61K45/06 ,  Y10S514/96 ,  Y10S514/964 ,  A61K2300/00

摘要： An antibiotic product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours.

公开(公告)号：EP1968586A2

公开(公告)日：2008-09-17

申请号：EP06845116.0

申请日：2006-12-08

申请人： Advancis Pharmaceutical Corporation

发明人： FLANNER, Henry, H. ,  GUTTENDORF, Robert, J. ,  CLAUSEN, Susan, P. ,  TREACY, Donald ,  BURNSIDE, Beth, A.

IPC分类号： A61K31/43

CPC分类号： A61K31/43

摘要： Disclosed are once-a-day penicillin-type antibiotic products, comprising at least one modified release dosage form comprising penicillin-type antibiotics and pharmaceutically acceptable carriers, that are administered once-a-day in a dosage and for a number of days that provide a Total T>MIC that is sufficient to achieve at least the minimum amount of bacterial eradication for treatment of a bacterial infection. In one embodiment the products provide a T>MIC90 in the serum for at least 5 hours (preferably for at least five consecutive hours), within a 24-hour dosing interval, for a given bacterial pathogen's MIC90, while providing a total dosage of the penicillin-type antibiotic for a 24-hour dosing interval.

公开(公告)号：EP1653924A2

公开(公告)日：2006-05-10

申请号：EP04780937.1

申请日：2004-08-12

申请人： Advancis Pharmaceutical Corporation

发明人： BURNSIDE, Beth, A. ,  FLANNER, Henry, H. ,  ROWLINGS, Colin

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K9/24 ,  A61K9/52 ,  A61K9/54

CPC分类号： A61K9/2081 ,  A61K9/1694 ,  A61K9/5084

摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there is a delayed release dosage form, as well as two or more delayed sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

公开(公告)号：EP1648407A2

公开(公告)日：2006-04-26

申请号：EP04778705.6

申请日：2004-07-20

申请人： Advancis Pharmaceutical Corporation

发明人： BURNSIDE, Beth, A. ,  FLANNER, Henry, H. ,  ROWLINGS, Colin

IPC分类号： A61K9/00

CPC分类号： A61K31/54 ,  A61K9/2077 ,  A61K31/545 ,  A61K31/7048

摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, a sustained release dosage form, and a delayed release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型，缓释剂型和延迟释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。

公开(公告)号：EP1487414A2

公开(公告)日：2004-12-22

申请号：EP03714005.0

申请日：2003-03-07

申请人： Advancis Pharmaceutical Corporation

发明人： RUDNIC, Edward, M. ,  ISBISTER, James, D. ,  TREACY, Jr., Donald, J. ,  WASSINK, Sandra, E.

IPC分类号： A61K9/14 ,  A61K9/22 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48

CPC分类号： A61K45/06 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5047 ,  A61K31/65 ,  A61K2300/00

摘要： Antibiotic products for delivering at least two different antibiotics, wherein the products are comprised of at least three or four dosage forms with different release profiles and the at least two different antibiotics are selected from specified antibiotic pairs.