公开(公告)号：EP2393497A1

公开(公告)日：2011-12-14

申请号：EP09839006.5

申请日：2009-02-17

申请人： Biovec LLC

发明人： SEHGAL, Lakshman, R. ,  WONG, Jonathan

IPC分类号： A61K31/7088 ,  A61P13/12 ,  A61K39/235 ,  A61K31/7105 ,  A61K38/36

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K38/44 ,  A61K39/001 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0075 ,  C07K14/7455 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12Y113/11052

摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

公开(公告)号：EP2099438A4

公开(公告)日：2011-09-28

申请号：EP07772782

申请日：2007-03-14

申请人： BIOVEC LLC

发明人： SEHGAL LAKSHMAN R ,  WONG JONATHAN

IPC分类号： A61K31/00 ,  A61K31/713 ,  A61K48/00 ,  C07H21/00

CPC分类号： C12N15/86 ,  A61K31/198 ,  A61K38/366 ,  A61K38/42 ,  A61K45/06 ,  A61K48/005 ,  A61K48/0058 ,  C12N2710/10343 ,  A61K2300/00

公开(公告)号：EP2393497A4

公开(公告)日：2012-07-25

申请号：EP09839006

申请日：2009-02-17

申请人： BIOVEC LLC

发明人： SEHGAL LAKSHMAN R ,  WONG JONATHAN

IPC分类号： A61K39/235 ,  A61K38/36 ,  A61K38/44 ,  A61K39/00 ,  A61K48/00 ,  A61P13/12 ,  C07K14/745 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K38/44 ,  A61K39/001 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0075 ,  C07K14/7455 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12Y113/11052

摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

公开(公告)号：EP2099438A2

公开(公告)日：2009-09-16

申请号：EP07772782.4

申请日：2007-03-14

申请人： Biovec LLC

发明人： SEHGAL, Lakshman, R. ,  WONG, Jonathan

IPC分类号： A61K31/00 ,  A61K31/713 ,  C07H21/00

CPC分类号： C12N15/86 ,  A61K31/198 ,  A61K38/366 ,  A61K38/42 ,  A61K45/06 ,  A61K48/005 ,  A61K48/0058 ,  C12N2710/10343 ,  A61K2300/00

摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another. aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM.protein or its variant using a stent.

公开(公告)号：EP2393497B1

公开(公告)日：2014-04-02

申请号：EP09839006.5

申请日：2009-02-17

申请人： Biovec LLC

发明人： SEHGAL, Lakshman, R. ,  WONG, Jonathan

IPC分类号： A61K39/235 ,  A61K38/36 ,  A61K38/44 ,  A61P13/12 ,  A61K39/00 ,  A61K48/00 ,  C07K14/745 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K38/44 ,  A61K39/001 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0075 ,  C07K14/7455 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12Y113/11052

摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

公开(公告)号：EP1835803A4

公开(公告)日：2011-11-30

申请号：EP06718042

申请日：2006-01-12

申请人： BIOVEC LLC

发明人： MOUSA SHAKER A ,  SEHGAL LAKSHMAN R

IPC分类号： A01N1/02

CPC分类号： A01N1/0215 ,  A01N1/02 ,  A01N1/0226

公开(公告)号：EP1835803A2

公开(公告)日：2007-09-26

申请号：EP06718042.2

申请日：2006-01-12

申请人： Biovec LLC

发明人： MOUSA, Shaker, A. ,  SEHGAL, Lakshman, R.

IPC分类号： A01N1/02

CPC分类号： A01N1/0215 ,  A01N1/02 ,  A01N1/0226

摘要： The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.

公开(公告)号：EP1573005A2

公开(公告)日：2005-09-14

申请号：EP03796526.6

申请日：2003-12-02

申请人： Biovec LLC

发明人： SEHGALL, Lakshman, R. ,  WONG, Jonathan

IPC分类号： C12N15/00 ,  A61K31/70

CPC分类号： A61K48/0058 ,  A61K38/366 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0075 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/30 ,  C12N2830/008 ,  C12N2830/42

摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.