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    Methods and compositions for the treatment of infection and control of flora using haloperoxidase
    3.
    发明公开
    Methods and compositions for the treatment of infection and control of flora using haloperoxidase 无效
    一种用于感染Haloperoxydase的治疗和植物的控制方法和组合物。

    公开(公告)号：EP0500387A2

    公开(公告)日：1992-08-26

    申请号：EP92301448.4

    申请日：1992-02-21

    申请人： EXOXEMIS, INC.

    发明人： Allen, Robert Charles

    IPC分类号： A61K37/50

    CPC分类号： A61L15/46 ,  A01N63/00 ,  A61K38/44 ,  A61L12/082 ,  A61L12/126 ,  A61L15/38 ,  A61L2300/254 ,  A61L2300/404 ,  A61K33/40 ,  A61K33/00 ,  A61K2300/00

    摘要： Haloperoxidases are used to selectively bind to and, in the presence of peroxide and halide, inhibit the growth of target microbes without eliminating desirable microbes or significantly damaging other components, such as host cells, in the environment of the target microbe. When a target microbe, e.g., a pathogenic microbe, has a binding capacity for haloperoxidase greater than that of a desired microbe, e.g., members of the normal flora, the target microbe selectively binds the haloperoxidase with little or no binding of the haloperoxidase by the desired microbe. In the presence of peroxide and halide, the target bound haloperoxidase catalyzes halide oxidation and facilitates the disproportionation of peroxide to singlet molecular oxygen at the surface of the target microbe. The lifetime of singlet molecular oxygen restricts damage to the surface resulting in selective killing of the target microbe with a minimum of collateral damage to the desired microbe or physiological medium. The methods and compositions of the invention are highly useful in the therapeutic or prophylactic antiseptic treatment of human or animal subjects, since their use can be designed to be highly effective in combatting bacterial or fungal infections without significant damage to normal flora or host cells. Suitable haloperoxidases include myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), chloroperoxidase (CPO) and derivatives thereof capable of selective binding to target microbes.

    摘要翻译： 卤代过氧化物酶被用于选择性地结合，并且在过氧化物和卤化物存在下，抑制目标微生物的生长而不消除较佳微生物或显着损坏其它部件，颜色：诸如宿主细胞，在所述目标微生物的环境中。 当目标微生物，例如，病原性微生物，有卤素过氧化物酶比所希望的微生物的大的结合能力，例如，正常菌群的成员，所述目标微生物选择性地结合与由很少或没有卤过氧化物酶结合的卤过氧化物酶 期望中的微生物。 在过氧化物和卤化物存在下，靶结合的卤过氧化物酶催化的氧化卤化物并有利于过氧化物的歧化在目标微生物的表面，以单线态分子氧。 单线态分子氧的寿命限制到该表面上以最小的到所需的微生物或生理介质中的附带损害的靶微生物的选择性杀伤造成的损害。 本发明的方法和组合物在人类或动物受试者的治疗性或预防性防腐处理是非常有用的，因为它们的使用可以被设计成在打击细菌或真菌感染，但无正常菌群或宿主细胞显著损害非常有效。 合适的卤代过氧化物酶包括髓过氧化物酶（MPO），嗜酸性粒细胞过氧化物酶（EPO），乳过氧化物酶（LPO），氯过氧化物（CPO）和衍生物能够选择性结合靶微生物体。

    METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF SEXUALLY TRANSMITTED DISEASES
    10.
    发明公开
    METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF SEXUALLY TRANSMITTED DISEASES 失效
    方法和组合物的预防和治疗性疾病的

    公开(公告)号：EP0693934A1

    公开(公告)日：1996-01-31

    申请号：EP94914718.0

    申请日：1994-03-21

    申请人： EXOXEMIS, INC.

    发明人： ALLEN, Robert C.

    IPC分类号： A61K38 ,  A61P31

    CPC分类号： A61K38/443 ,  A61K2300/00

    摘要： Methods and compositions for the prophylaxis and/or treatment of sexually transmitted diseases (STDs) are disclosed, in which amounts of a haloperoxidase, such as myeloperoxidase or eosinophil peroxidase, and a semen substrate-specific oxidase are administered to a human or animal subject in the environment of sexually transmitted fluids. In the presence of semen, the semen substrate-specific oxidase catalyzes the production of hydrogen peroxide, which in turn is utilized by the haloperoxidase to selectively inhibit pathogenic microbes present in the sexually transmitted fluids. At high concentration levels, the compositions additionally exhibit spermicidal properties.