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公开(公告)号：EP3640330A1
公开(公告)日：2020-04-22
申请号：EP18200482.0
申请日：2018-10-15
申请人： Consiglio Nazionale Delle Ricerche , Istituto Nazionale Di Genetica Molecolare-INGM , IFOM Fondazione Istituto Firc di Oncologia Molecolare
发明人： LANZUOLO, Chiara , MARULLO, Fabrizia , LUCINI, Federica , FERRARI, Francesco , SEBESTYÉN, Endre
IPC分类号： C12N15/10
摘要： The present invention relates to an in vitro method for analyzing chromosomal nucleic acids, the method comprising:
a) providing at least one isolated cell that comprises genetic material and
b) performing a salt-based sequential fractionation of genetic material to separate genomic regions on the basis of their accessibility and obtain chromatin fractions and
c) extracting the nucleic acids from the above chromatin fractions and
d) optionally sonicating the extracted nucleic acids such that chromatin is fragmented to have comparable profile of different fractions and
e) sequencing the extracted nucleic acids of step c) or the sonicated nucleic acid of step d).-
2.发明公开HEMATOPOIETIC CELLS EXPRESSING THE PROTEIN KRTCAP3 AND LIGANDS FOR THE PROTEIN KRTCAP3 审中-公开造血干细胞对蛋白质KRTCAP3用于蛋白质表达KRTCAP3和配体
公开(公告)号：EP2257621A1
公开(公告)日：2010-12-08
申请号：EP09725161.5
申请日：2009-03-26
IPC分类号： C12N5/06 , C07K14/705
CPC分类号： C07K14/705 , A61K35/26 , A61K35/28 , A61K38/2013 , C12N5/0635 , G01N33/5047 , G01N33/564 , G01N33/6893 , G01N2500/00 , G01N2800/24 , A61K2300/00
摘要： The present invention relates to ex vivo hematopoietic cells characterized by the expression of the protein KRTCAP3 on the surface of said cells, to methods for isolating said cells and to ligands for KRTCAP3.
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公开(公告)号：EP2721413B1
公开(公告)日：2016-02-03
申请号：EP12733615.4
申请日：2012-06-14
IPC分类号： G01N33/564 , G01N33/576
CPC分类号： G01N33/6893 , G01N33/564 , G01N2800/085
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4.发明公开Biomarkers of liver diseases and uses thereof 审中-公开Biomarker von Lebererkrankungen und Verwendungen davon
公开(公告)号：EP2829613A1
公开(公告)日：2015-01-28
申请号：EP13178245.0
申请日：2013-07-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to miR-122 and miR-885-5p and their use in diagnostic and/or prognostic methods of liver diseases as well as modulators of miR-885-Sp for the treatment and/or prevention of a liver disease.
摘要翻译： 本发明涉及miR-122和miR-885-5p及其在肝脏疾病的诊断和/或预后方法中的用途以及用于治疗和/或预防肝脏疾病的miR-885-Sp的调节剂。
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公开(公告)号：EP2152858A2
公开(公告)日：2010-02-17
申请号：EP08751037.6
申请日：2008-05-27
CPC分类号： C12N5/0647 , A61K35/12 , A61K38/1709 , C12N5/0634 , C12N5/0645
摘要： The present invention relates to ex-vivo cells belonging to the hematopoietic system, characterized by the presence of MOSC-1 protein on cell surface, methods for isolating them and uses thereof.
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6.发明公开SUB -POPULATION OF HEMATOPOIETIC STEM CELLS THAT EXPRESS THE CRISP-1 PROTEIN 审中-公开造血干细胞的CRISP-1蛋白表达的亚群
公开(公告)号：EP2108044A2
公开(公告)日：2009-10-14
申请号：EP08709746.5
申请日：2008-01-31
CPC分类号： C12N5/0647
摘要： The subject of the present invention is a sub- population of isolated hematopoietic stem cells that express the CRISP-1 gene and produce the CRISP-1 protein on the cytoplasmic membrane of the cell, their isolation and their application in the therapeutic/diagnostic/prognostic field.
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公开(公告)号：EP3597653A1
公开(公告)日：2020-01-22
申请号：EP18184450.7
申请日：2018-07-19
申请人： IRBM S.P.A. , Promidis S.r.l. , Ospedale San Raffaele S.r.l. , Istituto Nazionale Di Genetica Molecolare-INGM
发明人： De Francesco, Raffaele , Donnici, Lorena , Guidotti, Luca , Iannacone, Matteo , Di Fabio, Romano , Summa, Vincenzo , Bencheva, Leda Ivanova , De Matteo, Marilenia , Ferrante, Luca , Prandi, Adolfo , Randazzo, Pietro
IPC分类号： C07D513/04 , A61K31/407 , C07D513/20 , C07D515/04 , C07D515/20 , C07D285/28 , C07D291/08 , A61P31/20
摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
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公开(公告)号：EP2653554A1
公开(公告)日：2013-10-23
申请号：EP12164436.3
申请日：2012-04-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a biomarker of immunity response for use in monitoring the acquired immunity of an immunized subject, to an in vitro method and a kit for monitoring the acquired immunity of an immunized subj ect.
摘要翻译： 本发明涉及用于监测免疫受试者的获得性免疫的免疫应答生物标志物，体外方法和用于监测免疫接种的获得性免疫的试剂盒。
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9.发明公开MICRORNA EXPRESSION SIGNATURE IN PERIPHERAL BLOOD OF PATIENTS AFFECTED BY HEPATOCARCINOMA OR HEPATIC CIRRHOSIS AND USES THEREOF 审中-公开microRNA表达签名肝癌或肝硬化和使用患者外周血中的
公开(公告)号：EP2475785A2
公开(公告)日：2012-07-18
申请号：EP10771185.5
申请日：2010-09-06
发明人： PAGANI, Massimiliano , DE FRANCESCO, Raffaele , ABRIGNANI, Sergio , ROSSETTI, Grazisa , ROSSI, Riccardo Lorenzo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： A method for diagnosing or prognosticating hepatocellular carcinoma, also in the early stages, or for assessing the risk of developing hepatocellular carcinoma, or for monitoring the effectiveness of an anti-tumour therapy against hepatocellular carcinoma by measuring the expression level of at least one miRNA gene product in a peripheral blood sample or in a biological fluid sample. Said method comprises measuring, in an isolated sample of peripheral blood or biological fluid, the expression level of at least one miRNA gene product, and comparing said measured expression level with a reference level. Such method can also be used to diagnose or assess the risk of developing liver cirrhosis in patients affected by chronic hepatitis, or to prognosticate the evolution of cirrhosis in patients affected by cirrhosis, or to monitor the effectiveness of a pharmacological therapy against liver cirrhosis.
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公开(公告)号：EP4103567B1
公开(公告)日：2024-10-23
申请号：EP21705131.7
申请日：2021-02-09
发明人： DI FABIO, Romano , SUMMA, Vincenzo , BENCHEVA, Leda Ivanova , DE FRANCESCO, Raffaele , DONNICI, Lorena , GUIDOTTI, Luca , IANNACONE, Matteo , PRANDI, Adolfo , DE MATTEO, Marilenia , RANDAZZO, Pietro
IPC分类号： C07D515/20 , A61K31/554 , A61P31/20
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