公开(公告)号：EP2511291A3

公开(公告)日：2012-11-07

申请号：EP12164042.9

申请日：2008-06-13

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Noiges, Birgit ,  Von Gabain, Alexander ,  Asklin, Johanna

IPC分类号： C07K14/295 ,  A61K39/118 ,  C07K16/12

CPC分类号： C07K14/295 ,  A61K39/118 ,  G01N33/56927 ,  G01N2469/20

摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia.

摘要翻译： 本发明涉及编码来自衣原体属物种的抗原的分离的核酸分子，包含此类核酸分子的载体和包含此类载体的宿主细胞。 此外，本发明提供了来自衣原体属的抗原及其片段和变体，生产这种抗原的方法，以及生产表达此类抗原的细胞的方法。 更具体地说，这样的抗原由肺炎衣原体引起的细菌感染产生或与之相关。 此外，本发明提供了与这样的抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，这种核酸分子，抗原， 载体或抗体用于制备药物组合物的方法，用于鉴定能够结合此类抗原的拮抗剂或减少或抑制此类抗原的相互作用活性的方法，用于诊断衣原体感染的方法以及用于治疗或预防感染的方法 与披衣菌。

公开(公告)号：EP2269626A3

公开(公告)日：2012-08-08

申请号：EP10010879.4

申请日：2008-01-10

申请人： Intercell AG

发明人： Tschanun, Beatrice

IPC分类号： A61K38/16 ,  C07K16/12

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/315 ,  C07K16/1275

摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.

公开(公告)号：EP2269624A3

公开(公告)日：2012-08-08

申请号：EP10010877.8

申请日：2008-01-10

申请人： Intercell AG

发明人： Tschanun, Beatrice ,  Nagy, Eszter ,  Meinke, Andreas ,  Gabain von, Alexander ,  Maierhofer, Barbara ,  Stierschneider, Ulrike ,  Berger, Manfred ,  Neubauer, Christina ,  Cohen, Katherine

IPC分类号： A61K38/16 ,  C07K16/12

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/315 ,  C07K16/1275

摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.

摘要翻译： 本发明涉及包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质的组合物; 一种针对无乳链球菌的保护肽; 编码所述至少两种蛋白质和/或所述保护肽的一种或多种核酸; 生产该组合物的方法; 包含该组合物和/或至少一种保护肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸在制造用于免疫或治疗受试者的药物中的用途; 诊断无乳链球菌感染的方法; 鉴定能够结合组合物和/或至少一种保护肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

公开(公告)号：EP2402026A3

公开(公告)日：2012-04-18

申请号：EP11166299.5

申请日：2003-08-27

申请人： Intercell AG

发明人： Buschle, Michael ,  Habel, Andre ,  Klade, Christoph ,  Mattner, Frank ,  Otava, Oleksandr ,  Vytvytska, Oresta ,  Zauner, Wolfgang ,  Zinke, Sandra ,  Kirlappos, Helen

IPC分类号： A61K39/12 ,  A61K39/29 ,  A61K39/39 ,  A61K38/00 ,  A61P31/00 ,  A61K39/145 ,  C07K14/11 ,  C07K14/18 ,  A61K38/16 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/525 ,  A61K2039/57 ,  C07K7/08 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16122 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N2500/04 ,  Y10S930/223

摘要： Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule characterized by the following steps: - providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecules and HCV-peptides which do not bind to said MHC/HLA molecule, -contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, -detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterising the HCV-peptide from said complex.

公开(公告)号：EP2405938A2

公开(公告)日：2012-01-18

申请号：EP10706974.2

申请日：2010-02-15

申请人： Intercell AG

发明人： VON GABAIN, Alexander ,  NAGY, Eszter ,  MEINKE, Andreas ,  SELAK, Sanja ,  HANNER, Markus ,  SMIDT, Margarita ,  WEISSGRAM, Michaela ,  NOIGES, Birgit ,  SEIDEL, Stefan ,  BACHER, Julia ,  SATKE, Christina ,  SCHUELER, Wolfgang ,  OLEKSIEWICZ, Martin

IPC分类号： A61K39/12 ,  C07K14/285 ,  C07K16/12 ,  C12R1/21

CPC分类号： C07K14/285 ,  A61K39/00 ,  A61K2039/53

摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable
Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable
Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable
Haemophilus influenzae . Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable
Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable
Haemophilus influenzae.

公开(公告)号：EP1987843A3

公开(公告)日：2011-10-26

申请号：EP07024331.6

申请日：2005-03-11

申请人： Intercell AG

发明人： Zauner, Wolfgang ,  Kritsch, Constantia ,  Heinrich-Cseh, Christa ,  Berger, Agnes

IPC分类号： A61K47/12 ,  A61K39/12 ,  C07K14/18

CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K47/12 ,  C12N2770/24222

摘要： Described is a method for making a pharmaceutical preparation comprising the solubilisation of a peptide mixture, wherein the peptide mixture is solubilized by an aqueous solution containing at least one organic acid selected from the group consisting of formic acid, acetic acid, propionic acid, butyric acid and halogenated or hydroxylated forms thereof whereby the concentration of the organic acid in the aqueous solution is at least 10% and wherein the peptide mixture contains peptides and/or polypeptides from hepatitis C virus (HCV).

公开(公告)号：EP2289907A3

公开(公告)日：2011-08-31

申请号：EP10178855.2

申请日：2004-05-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Hanner, Markus ,  Horky, Markus ,  Kallenda, Sabine ,  Prustomersky, Sonja

IPC分类号： C07K14/315 ,  A61K39/09 ,  C12N15/31 ,  C07K16/12 ,  C12Q1/68 ,  C12N15/11 ,  G01N33/50

CPC分类号： C07K16/1275 ,  C07K14/315 ,  C07K2317/00

摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, methods for isolating such antigens and specific uses thereof.

摘要翻译： 本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自无乳链球菌的超免疫血清反应性抗原或其片段，分离这些抗原的方法及其特定用途。

公开(公告)号：EP2360177A1

公开(公告)日：2011-08-24

申请号：EP10010874.5

申请日：2008-04-29

申请人： Intercell AG

发明人： Bakshi, Sharmila ,  Cipps, Thomas ,  Hanner, Markus ,  Pikalo, Jutta ,  Satke, Christina ,  Nagy, Eszter ,  Lundberg, Urban ,  Wakefield, Dagmar ,  Meinke, Andreas ,  Noiges, Birgit ,  Stierschneider, Ulrike ,  von Gabain, Alexander

IPC分类号： C07K14/26 ,  C07K16/12 ,  A61K39/395 ,  A61P31/04

CPC分类号： C07K14/26 ,  A61K39/00 ,  A61K39/0266 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K16/1228 ,  C07K2317/21

摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

摘要翻译： 本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。 此外，本发明提供了来自克雷伯杆菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。 此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原， 用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。 更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

公开(公告)号：EP2338902A1

公开(公告)日：2011-06-29

申请号：EP10010873.7

申请日：2008-04-29

申请人： Intercell AG

发明人： Bakshi, Sharmila ,  Cipps, Thomas ,  Hanner, Markus ,  Pikalo, Jutta ,  Satke, Christina ,  Nagy, Eszter ,  Lundberg, Urban ,  Wakefield, Dagmar ,  Meinke, Andreas ,  Noiges, Birgit ,  Stierschneider, Ulrike ,  von Gabain, Alexander

IPC分类号： C07K14/26 ,  C07K16/12 ,  A61K39/395 ,  A61P31/04

CPC分类号： C07K14/26 ,  A61K39/00 ,  A61K39/0266 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K16/1228 ,  C07K2317/21

摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

摘要翻译： 本发明涉及编码抗原的分离的核酸分子，包含此类核酸分子的载体和包含此类载体的宿主细胞。 此外，本发明提供了来自克雷伯氏菌属物种的抗原及其片段和变体，生产这种抗原的方法，以及生产表达这种抗原的细胞的方法。 此外，本发明提供了与这样的抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，这种核酸分子，抗原， 载体或抗体用于制备药物组合物的方法，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法和用于治疗或预防感染的方法。 更具体地说，此类抗原由细菌病原体产生或与细菌病原体相关，所述细菌病原体引起由肺炎克雷伯氏菌引起的院内感染或细菌感染。

公开(公告)号：EP2292645A3

公开(公告)日：2011-05-25

申请号：EP10010868.7

申请日：2007-07-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Von Gabain, Alexander ,  Berger, Manfred ,  Tschanun, Beatrice ,  Schunn, Michael

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes ( S. pyogenes ) of SEQ ID NO: 1 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

摘要翻译： 本发明涉及由SEQ ID NO：1的化脓链球菌（化脓链球菌）的一种抗原或其功能活性变体组成的肽，其任选进一步由另外的氨基酸残基组成; 编码它的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 特异性结合抗原的抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断化脓性链球菌感染的方法; 鉴定能够结合所述肽的配体的方法; 以及所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定的用途。