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    AMADORIASE HAVING IMPROVED ANIONIC-SURFACTANT RESISTANCE
    1.
    发明公开
    AMADORIASE HAVING IMPROVED ANIONIC-SURFACTANT RESISTANCE 审中-公开

    公开(公告)号：EP3216865A4

    公开(公告)日：2018-05-23

    申请号：EP15856363

    申请日：2015-11-06

    申请人： KIKKOMAN CORP

    发明人： MASAKARI YOSUKE ,  KOMATSUZAKI AIRI

    IPC分类号： C12N15/53 ,  C12N9/02 ,  C12Q1/26

    CPC分类号： C12N9/0032 ,  C12Q1/26 ,  C12Y105/03

    摘要： The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.

    MODIFIED AMADORIASE CAPABLE OF ACTING ON FRUCTOSYL HEXAPEPTIDE
    2.
    发明公开
    MODIFIED AMADORIASE CAPABLE OF ACTING ON FRUCTOSYL HEXAPEPTIDE 审中-公开
    ZUR WIRKUNG AUF FRUCTOSYLHEXAPEPTIDFÄHIGE，MODIFIZIERTE AMADORIASE

    公开(公告)号：EP2843050A4

    公开(公告)日：2016-03-02

    申请号：EP13781492

    申请日：2013-04-26

    申请人： KIKKOMAN CORP

    发明人： ICHIYANAGI ATSUSHI ,  MASAKARI YOSUKE

    IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12Q1/48

    CPC分类号： C12Q1/26 ,  C12N9/0032 ,  G01N33/723 ,  G01N2333/90672

    摘要： This invention provides an amadoriase having high reactivity with ±-fructosyl hexapeptide (±F6P) derived from the ²-chain amino terminus of glycated hemoglobin (HbAlc), which enables satisfactory quantification of ±F6P cleaved from HbAlc. A novel amadoriase is derived from the amadoriase of the genus Coniochaeta by substitution of one or more amino acids at positions selected from the group consisting of positions 62, 63, 102, 106, 110, 113, 355, and 419. Such amadoriase enables rapid, simple, accurate, and satisfactory quantification of ±F6P cleaved from HbAlc. With the use of such amadoriase, a method for measurement of HbAlc by an enzymatic method and a kit for measurement of HbAlc that are based on the same principle as used in the conventional standard method and excellent in terms of the relevance with the standard method.

    摘要翻译： 本发明提供了一种与衍生自糖基化血红蛋白（HbAlc）的2-链氨基末端的± - 果糖基六肽（±F6P）具有高反应性的阿马替利酶，其能够令人满意地定量从HbAlc切割的±F6P。 一种新的阿马道里酶通过在选自位置62,63,102,106,110,113,355和419的位置取代一个或多个氨基酸衍生自Coniochaeta属的阿马道里酶。这种阿马道里酶能够快速 ，从HbAlc切割的±F6P的简单，准确和令人满意的定量。 使用这种阿马道里酶，通过酶法测定HbAlc的方法和用于测量HbAlc的试剂盒，其基于与常规标准方法中使用的相同原理，并且与标准方法的相关性优异。

    LACTIC ACID BACTERIUM CAPABLE OF PRODUCING -AMINOBUTYRIC ACID
    10.
    发明公开
    LACTIC ACID BACTERIUM CAPABLE OF PRODUCING -AMINOBUTYRIC ACID 有权
    需要有能力的乳酸菌生产氨基丁酸

    公开(公告)号：EP1988155A4

    公开(公告)日：2009-05-06

    申请号：EP07714723

    申请日：2007-02-21

    申请人： KIKKOMAN CORP

    发明人： HANYA YOSHIKI ,  SATO ITSUO ,  SHIMOJO RYO

    IPC分类号： C12N1/20 ,  C12P13/00 ,  C12R1/225

    CPC分类号： C12R1/225 ,  C12N1/20 ,  C12P13/005

    摘要： It is intended to provide a lactic acid bacterium which is capable of producing ?-aminobutyric acid (GABA) even in the coexistence of lactic acid and sodium chloride in the medium at the initiation of the culture; and a method of producing a culture product containing GABA. More specifically speaking, a lactic acid bacterium Lactobacillus rennini, which is capable of producing GABA even in the coexistence of lactic acid and sodium chloride in the medium at the initiation of the culture, is isolated from soy sauce moromi (mash). Then, this lactic acid bacterium is inoculated into a medium containing L-glutamic acid and/or its salt and cultured therein. Thus, a culture product containing GABA can be obtained.