-
1.发明公开
公开(公告)号：EP4431608A2
公开(公告)日：2024-09-18
申请号：EP24171660.4
申请日：2018-05-01
发明人： ABE, Keietsu , YOSHIMI, Akira , MIYAZAWA, Ken , TABATA, Fuka , GOMI, Katsuya , SANO, Motoaki
IPC分类号： C12N15/80
CPC分类号： C12P21/02 , C12N9/18 , C12N15/80 , C12N9/1051 , C12N9/90
摘要： Provided is a mutant filamentous fungus, which lacks expression of α-1,3-glucan, and is deficient in at least part of a GAG biosynthetic cluster. Also provided is a method of producing a substance, including the steps of: culturing the filamentous fungus to allow the filamentous fungus to produce a substance; and collecting the resulting substance.
-
公开(公告)号：EP4417622A1
公开(公告)日：2024-08-21
申请号：EP22885830.4
申请日：2022-10-24
发明人： MA, Bruce Yong , CAO, Peipei , HANG, Jianhua , GE, Chennan , ZHANG, Tao , SUN, Fang , YAO, Xiang
IPC分类号： C07K16/28 , C07K16/46 , C12N15/13 , C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , A61K39/395 , A61P35/00
CPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/46 , C12N15/63 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/85
摘要： Provided are antibodies or antigen-binding fragments that bind to human CD26, bispecific T-cell engagers comprising the sequence of such antibodies or antigen-binding fragments, and applications of such antibodies or antigen-binding fragments in the preparation of drugs for the treatment of tumors with high expression of CD26.
-
公开(公告)号：EP4407039A1
公开(公告)日：2024-07-31
申请号：EP22872950.5
申请日：2022-09-21
申请人： Kao Corporation
CPC分类号： Y02E50/10 , C07K14/195 , C12N9/2414 , C12N9/2408 , C12N15/80 , C12P19/14 , C12N9/2434 , C12N9/24
摘要： Provided is a method for producing a saccharifying enzyme which prevents an increase in viscosity caused by pectin in the biomass saccharification process.
A method for producing a biomass saccharifying enzyme, comprising culturing a recombinant filamentous fungus into which one or both of a polygalacturonase gene selected from the following gene group (a) and a pectin lyase gene selected from the following gene group (b) are introduced:
(a) PgaB gene, PgaI gene, and PgaII gene; and
(b) PelD gene and PelF gene.-
公开(公告)号：EP4400589A1
公开(公告)日：2024-07-17
申请号：EP22867379.4
申请日：2022-09-07
发明人： ODAKA, Rei , SANO, Ryoko , IWASAKI, Takumi , BABA, Masahiro , SABURI, Wataru , MORI, Haruhide
IPC分类号： C12N15/56 , A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/38 , C12N15/63
CPC分类号： A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N5/10 , C12N9/24 , C12N9/2468 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74
摘要： Provided is a lactase preparation having an excellent lactose decomposing action in milk. A lactase according to an aspect of the present invention has, as lactase activity, any one of the following activities (1) to (6) or a combination of two or more thereof:
(1) when the lactase is added to cow's milk, an added amount of protein in the lactase at which a residual lactose concentration reaches 0.1% or less after 16 hours at 10°C is 15.1 mg/L or less;
(2) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 16 hours at 10°C is 30.2 mg/L or less;
(3) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C is 10.1 mg/L or less;
(4) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C is 15.1 mg/L or less;
(5) when the lactase is added to cow's milk in an amount that makes a final concentration 1.4 LYU/ml, the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C; and
(6) when the lactase is added to cow's milk in the amount that makes a final concentration 2.1 LYU/ml, the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C.-
公开(公告)号：EP4400587A1
公开(公告)日：2024-07-17
申请号：EP22867164.0
申请日：2022-08-19
IPC分类号： C12N15/54 , B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12P5/02
CPC分类号： B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74 , C12P5/02
摘要： The present invention aims to provide a method for producing a trans-polyisoprenoid (trans-1,4-polyisoprene) with a molecular weight of more than 105 in an enzymatic manner. The present invention relates to a method for producing a trans-polyisoprenoid, which includes binding to a lipid membrane in vitro a trans-prenyltransferase (tPT) family protein capable of producing a product with a molecular weight of 104 or more when not bound to any lipid membrane.
-
公开(公告)号：EP4388077A1
公开(公告)日：2024-06-26
申请号：EP22764986.0
申请日：2022-08-19
申请人： Danisco US Inc.
-
公开(公告)号：EP4379054A1
公开(公告)日：2024-06-05
申请号：EP22849476.1
申请日：2022-07-26
发明人： KABAYAMA, Hiroyuki
IPC分类号： C12N15/12 , C07K7/00 , C07K14/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/62 , C12N15/63
CPC分类号： C07K14/00 , C07K16/00 , C12N15/80 , C12N15/81 , C07K14/435 , C07K7/00 , C12N15/62 , C12N15/63 , C12N15/74 , C12N5/10
摘要： The present disclosure provides a peptide tag, and a nucleic acid encoding the peptide tag. The peptide tag of the present disclosure can reduce an aggregation property of a protein in a cell. Specifically, the peptide tag of the present disclosure can be a peptide tag in which 5% or more and less than 45% of amino acids contained in an amino acid sequence thereof are acidic amino acids, and (b) 20% or more of the amino acids contained in the amino acid sequence are amino acids selected from the group consisting of F, P, Y, G, S, Q, N, and A.
-
公开(公告)号：EP4361259A1
公开(公告)日：2024-05-01
申请号：EP22842518.7
申请日：2022-07-15
发明人： PARK, Hye Min , LEE, Peter , LEE, Dong Pil , KIM, Jae Eung
CPC分类号： C12P23/00 , C12N9/0004 , C12N15/80 , C12N15/52
摘要： The present disclosure relates to a novel beta-carotene 15,15'-oxygenase variant, a microorganism including the variant, a method for producing a retinoid using the microorganism, a composition for producing a retinoid, and use of the variant or microorganism for producing a retinoid.
-
公开(公告)号：EP3411485A1
公开(公告)日：2018-12-12
申请号：EP17747883.1
申请日：2017-02-02
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John , YAP, Sihui Amy
IPC分类号： C12N15/80 , C12N15/113
摘要： The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil- accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
-
公开(公告)号：EP3322807B1
公开(公告)日：2018-12-05
申请号：EP16747631.6
申请日：2016-07-15
发明人： SHINKAWA, Satoru , MITSUZAWA, Shigenobu , TANAKA, Maiko , MACHIDA, Masayuki , HAGIWARA, Hiroko , KOIKE, Hideaki , KUNINAGA, Mahoko
CPC分类号： C12N15/80 , C12N1/14 , C12N15/113 , C12N15/62 , C12N15/63
摘要： To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.
-
-
-
-
-
-
-
-
-
搜索结果
926 条记录 (耗时 0.031 秒)
