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    TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE
    4.
    发明公开
    TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE 有权
    飞行时间质谱仪的串联时间和使用方法

    公开(公告)号：EP1522087A1

    公开(公告)日：2005-04-13

    申请号：EP03726518.8

    申请日：2003-04-29

    申请人： LECO CORPORATION

    发明人： VERENTCHIKOV, Anatoli, N.

    IPC分类号： H01J49/40

    CPC分类号： H01J49/406 ,  H01J49/004

    摘要： To provide comprehensive (i.e. rapid and sensitive) MS-MS analysis, the inventor employs a time-nested separation, using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to l00eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. Low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Since separation in TOF1 takes milliseconds and mass analysis in TOF2- microseconds, the invention provides comprehensive MS-MS analysis of multiple precursor ions per single ion pulse. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. The TOF-TOF could be implemented using a static TOF1, here described on the examples of spiratron, planar and cylindrical multi-pass separators with griddles spatial focusing ion mirrors. Higher performance is expected with the use of novel hybrid TOF 1 analyzers, combining radio frequency (RF) and quadratic DC fields. RF field retains low-energy ions within TOF 1 analyzer, while quadratic DC field improves resolution by compensate for large relative energy spread.

    摘要翻译： 为了提供全面的（即快速和灵敏的）MS-MS分析，发明人采用时间嵌套分离，使用两个飞行时间（TOF）质谱仪。 母离子在缓慢且长的TOF1中分离，以低离子能量（1至100eV）操作，并且碎片离子在快速且短的TOF2中进行质量分析，在更高的keV能量下操作。 TOF1和TOF2之间的低能量碎裂室适合加速破碎和抑制步骤，主要是通过缩短池和采用更高的气体压力。 由于TOF1中的分离需要几毫秒的时间并且TOF2微秒内的质量分析，因此本发明提供了每单个离子脉冲的多个前体离子的全面MS-MS分析。 引入新颖的TOF1分析仪，可以在TOF1中快速分离。 TOF-TOF可以使用静态TOF1来实现，这里用spiratron，平面和圆柱形多通道分离器以及栅格空间聚焦离子镜的例子进行描述。 使用新型混合TOF 1分析仪，结合无线电频率（RF）和二次DC场，可以获得更高的性能。 RF场保留TOF 1分析仪内的低能离子，而二次DC场通过补偿较大的相对能量扩散来提高分辨率。

    AUTOMATIC CRUCIBLE AND SAMPLE LOADING SYSTEM AND METHOD
    5.
    发明公开
    AUTOMATIC CRUCIBLE AND SAMPLE LOADING SYSTEM AND METHOD 审中-公开
    自动坩埚和样品装载系统和方法

    公开(公告)号：EP1490698A1

    公开(公告)日：2004-12-29

    申请号：EP03714081.1

    申请日：2003-03-11

    申请人： LECO CORPORATION

    发明人： FORD, Gordon, C.

    IPC分类号： G01N35/00

    CPC分类号： B01L3/04 ,  F27D2019/0003 ,  G01N33/206 ,  G01N35/04 ,  G01N2035/0406 ,  G01N2035/0427 ,  G01N2035/0463

    摘要： A crucible and sample handling system and method provides a crucible-holding cartridge (50) which is prepackaged to hold a plurality of crucibles (30). Upon removal of an end cap exposing an exit aperture, it is loaded onto a crucible delivery assembly which discharges individual crucibles (30) from the cartridge (50) on a platform (92) where a pick-and-place arm (200) assembly places the crucible (30) in a combustion furnace (40). Individual samples are dropped from stacked sample holding carousels (340-345) onto a balance (25), after weighing, are pneumatically drawn from the balance and introduced into the furnace (40) and crucible (30) for combustion.

    Glow discharge analytical instrument
    6.
    发明公开
    Glow discharge analytical instrument 失效
    分析仪

    公开(公告)号：EP0636877A1

    公开(公告)日：1995-02-01

    申请号：EP94305573.1

    申请日：1994-07-28

    申请人： LECO CORPORATION

    发明人： Mitchell, Joel Carlton ,  Casper, Ted Joseph

    IPC分类号： G01N21/68 ,  H01J49/10

    CPC分类号： H01J49/105 ,  G01N21/68

    摘要： A non-conductive isolator (10) for supporting a sample (137) to be analyzed by radio frequency energy induced glow discharge techniques has a conductive ring (19) for coupling a source of radio frequency energy to the same surface of the sample which is in direct contact with the induced glow discharge. An adapter kit for converting a direct current glow discharge analysis apparatus to a radio frequency energy induced flow discharge is described as well as the method of analysing non-conductive and conductive samples using a source of RF energy coupled to the same sample surface being analyzed.

    摘要翻译： 用于支持通过射频能量感应辉光放电技术分析的样品（137）的非导电隔离器（10）具有用于将射频能源耦合到样品的相同表面的导电环（19），该导电环 与感应辉光放电直接接触。 描述了用于将直流辉光放电分析装置转换为射频能量感应流放电的适配器套件，以及使用耦合到正在分析的相同样品表面的RF能量源分析非导电和导电样品的方法。

    Sample autoloader
    7.
    发明公开
    Sample autoloader 失效
    自动售货机。

    公开(公告)号：EP0615127A1

    公开(公告)日：1994-09-14

    申请号：EP94301577.6

    申请日：1994-03-07

    申请人： LECO CORPORATION

    发明人： Hemzy, Wayne R. ,  Knapp, Thomas G.

    IPC分类号： G01N31/12 ,  G01N35/02

    CPC分类号： B01L7/00 ,  F27B17/02 ,  F27D3/00 ,  G01N31/12 ,  G01N35/04 ,  G01N2035/00356 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0462 ,  Y10S414/14

    摘要： A sample autoloader (50) loads a sample into a furnace (54) and removes a sample from the furnace. The sample autoloader includes a sealing plate (70) for sealing the furnace. The sample autoloader also includes a mechanism (76) for pushing a sample into the furnace and removing a sample from the furnace . The sample autoloader may include a hotel (56) which stores sample containers (52) for automatic loading and a container (86) which receives spent sample containers.

    摘要翻译： 自动样品装载机（50）具有可连接到炉的框架，并且支撑马达（59），其驱动可沿形成框架的一部分的导杆移动的托架（58）。 滑架支撑在一端连接到致动器的旋转件，另一端钩住。 杆通过具有封闭件的炉密封件（70）中的封闭构件延伸。 密封件可从炉密封位置可逆地移动。

    IMPROVED ION MIRROR AND ION-OPTICAL LENS FOR IMAGING
    9.
    发明公开
    IMPROVED ION MIRROR AND ION-OPTICAL LENS FOR IMAGING 审中-公开

    公开(公告)号：EP3381045A1

    公开(公告)日：2018-10-03

    申请号：EP16869126.9

    申请日：2016-11-21

    申请人： Micromass UK Limited ,  Leco Corporation

    发明人： HOYES, John Brian ,  VERENCHIKOV, Anatoly ,  YAVOR, Mikhail ,  RICHARDSON, Keith

    IPC分类号： H01J49/40

    CPC分类号： H01J49/406 ,  H01J49/063 ,  H01J49/067 ,  H01J49/068 ,  H01J49/08

    摘要： An ion mirror is disclosed comprising an ion entrance electrode section (62) at the ion entrance to the ion mirror, an energy focussing electrode section (66) for reflecting ions back along a longitudinal axis towards said ion entrance, and a spatial focussing electrode section (64) arranged between the ion entrance electrode section (62) and the energy focussing electrode section (66) for spatially focussing the ions. One or more DC voltage supply is provided to apply a DC potential to the ion entrance electrode section (62) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the energy focussing electrode section (66). The ion mirror further comprises: (i) at least one first transition electrode (68) arranged between said ion entrance electrode section (62) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one first transition electrode that is intermediate the DC potential applied to the ion entrance electrode section (62) and the DC potential applied to the spatial focussing electrode section (64); and (ii) at least one second transition electrode (69) arranged between said energy focussing electrode section (66) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one second transition electrode (69) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the ion entrance electrode section (62).

    TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE
    10.
    发明授权
    TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE 有权
    TANDEM FLUZEITMASSENSPEKTROMETER和程序

    公开(公告)号：EP1522087B1

    公开(公告)日：2011-03-09

    申请号：EP03726518.8

    申请日：2003-04-29

    申请人： LECO CORPORATION

    发明人： VERENTCHIKOV, Anatoli, N.

    IPC分类号： H01J49/40

    CPC分类号： H01J49/406 ,  H01J49/004

    摘要： To provide comprehensive (i.e. rapid and sensitive) MS-MS analysis, the inventor employs a time-nested separation, using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to l00eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. Low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Since separation in TOF1 takes milliseconds and mass analysis in TOF2- microseconds, the invention provides comprehensive MS-MS analysis of multiple precursor ions per single ion pulse. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. The TOF-TOF could be implemented using a static TOF1, here described on the examples of spiratron, planar and cylindrical multi-pass separators with griddles spatial focusing ion mirrors. Higher performance is expected with the use of novel hybrid TOF 1 analyzers, combining radio frequency (RF) and quadratic DC fields. RF field retains low-energy ions within TOF 1 analyzer, while quadratic DC field improves resolution by compensate for large relative energy spread.