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    METHOD FOR CONTROLLING GALACTOSYLATION OF RECOMBINANT PROTEIN THROUGH OPTIMIZATION OF CULTURE MEDIUM
    4.
    发明公开
    METHOD FOR CONTROLLING GALACTOSYLATION OF RECOMBINANT PROTEIN THROUGH OPTIMIZATION OF CULTURE MEDIUM 审中-公开
    VERFAHREN ZUR STEUERUNG DER GALACTOSYLIUNG VON REKOMBINANTEM PROTEIN DURCH OPTIMIERUNG DES KULTURMEDIUMS

    公开(公告)号：EP3101120A1

    公开(公告)日：2016-12-07

    申请号：EP15743963.9

    申请日：2015-01-29

    申请人： LG Life Sciences Ltd.

    发明人： JUNG, Jun ,  SONG, Won Seok ,  LEE, Jun Eok ,  KIM, Yeon Chul

    IPC分类号： C12N5/02 ,  C12N5/071 ,  C07K16/18

    CPC分类号： C12P21/005 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/41 ,  C12N2500/32 ,  C12N2500/60

    摘要： Disclosed are a method for preparing a target recombinant protein with modulated galactosylation or a method for modulating the galactosylation of a target recombinant protein, including increasing the osmolality of a culture solution of animal cells which express a target recombinant protein during the animal cell culture; a method for preparing a target recombinant protein with modulated galactosylation or a method for modulating the galactosylation of a target recombinant protein, including supplementing asparagine to a culture solution of animal cells which express a target recombinant protein during the animal cell culture; a method for preparing a target recombinant protein with modulated galactosylation or a method for modulating the galactosylation of a target recombinant protein, including increasing the osmolality of an animal cell culture which expresses a target recombinant protein and supplementing asparagine thereto during the animal cell culture; and a target recombinant protein with modulated galactosylation, which is prepared by the method.

    摘要翻译： 公开了一种制备具有调节的半乳糖基化的靶重组蛋白的方法或调节靶重组蛋白的半乳糖基化的方法，包括增加在动物细胞培养期间表达靶重组蛋白的动物细胞培养液的重量克分子渗透压浓度; 制备具有调节的半乳糖基化的靶重组蛋白的方法或调节靶重组蛋白的半乳糖基化的方法，包括在动物细胞培养期间向表达靶重组蛋白的动物细胞的培养液中补充天冬酰胺; 用于制备具有调节的半乳糖基化的靶重组蛋白的方法或调节靶重组蛋白的半乳糖基化的方法，包括在动物细胞培养期间增加表达靶重组蛋白并在其中补充天冬酰胺的动物细胞培养物的重量克分子渗透压浓度; 和通过该方法制备的具有调节的半乳糖基化的靶重组蛋白。

    NON-AQUEOUS OILY INJECTABLE FORMULATION EXHIBITING PRESERVATIVE EFFICACY
    5.
    发明公开
    NON-AQUEOUS OILY INJECTABLE FORMULATION EXHIBITING PRESERVATIVE EFFICACY 审中-公开
    NICHTWÄSSRIGEUNDÖLIGEINJEKTIONSFORMULIERUNG MIT KONSERVIERUNGSWIRKUNG

    公开(公告)号：EP2616047A4

    公开(公告)日：2016-04-27

    申请号：EP11825390

    申请日：2011-09-09

    申请人： LG LIFE SCIENCES LTD

    发明人： SO JIN EON ,  YEO DONG JUN ,  JANG YOON-SEON

    IPC分类号： A61K31/728 ,  A61K9/08

    CPC分类号： A61K47/10 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/728 ,  A61K47/14

    摘要： Disclosed herein is preferably a multi-dose type non-aqueous oily injectable formulation including; an active ingredient (drug) expressing therapeutic effects, which is dissolved, dispersed or suspended in a therapeutically effective amount, in oil. The disclosed non-aqueous oily injectable formulation may include; an oil-affinitive preservative, and a hydrophilic excipient non-phase separable from the oil-affinitive preservative when the excipient is mixed with the oil-affinitive preservative.

    摘要翻译： 本文公开的是多剂型非油性可注射制剂，其包括： 表达治疗效果的活性成分（药物），其以治疗有效量溶解，分散或悬浮在油中。 所公开的非水性油性可注射制剂可包括： 油性亲和性防腐剂，以及当赋形剂与油性亲和性防腐剂混合时，与油性亲和性防腐剂可分离的亲水性赋形剂非相。