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    Vaccine for preventing and treating porcine progressive atrophic rhinitis
    4.
    发明公开
    Vaccine for preventing and treating porcine progressive atrophic rhinitis 有权
    疫苗预防和治疗猪进行性萎缩性鼻炎

    公开(公告)号：EP1657248A3

    公开(公告)日：2006-05-24

    申请号：EP05017940.7

    申请日：2005-08-18

    申请人： National Chung-Hsing University

    发明人： Chien, Maw-Sheng ,  Liu, Cheng-I ,  Liao, Chih-Ming

    IPC分类号： C07K14/285 ,  A61K39/102 ,  C12N15/09

    CPC分类号： A61K39/102 ,  C07K14/285

    摘要： The present invention relates to an animal vaccine directed to progressive atrophic rhinitis (PAR), comprising at least two fragmens of recombinant subunit Pasteurella multocida toxins (rsPMT) capable of eliciting the production of antibodies against Pasteurella multocida associated with PAR, said fragments each having an amino acid sequence that substantially corresponds to the 2-486, 486-986 or 986-1281 amino acid residues of Pasteurella multocida toxin (PMT), respectively. Also disclosed is a multivalent animal vaccine, comprising said fragments as active components against PAR, and at least a pathogenic antigen or epitope thereof associated with other animal disease(s), such as inactivated gE-deleted Pseudorabies virus.

    摘要翻译： 本发明涉及针对进行性萎缩性鼻炎（PAR）的动物疫苗，其包含至少两个重组亚单位出血败血性巴斯德氏菌毒素（rsPMT）片段，其能够引发产生针对与PAR相关的多杀巴斯德氏菌的抗体，所述片段各自具有 氨基酸序列分别基本上对应于多杀巴斯德氏菌毒素（PMT）的2-486,486-986或986-1281个氨基酸残基。 还公开了多价动物疫苗，其包含所述片段作为针对PAR的活性成分，以及至少与其他动物疾病（例如失活的gE缺失的伪狂犬病病毒）相关的致病性抗原或其表位。

    HIGH FREQUENCY VIBRATION SPINDLE SYSTEM
    5.
    发明公开
    HIGH FREQUENCY VIBRATION SPINDLE SYSTEM 审中-公开

    公开(公告)号：EP3456461A1

    公开(公告)日：2019-03-20

    申请号：EP18159110.8

    申请日：2018-02-28

    申请人： National Chung-Hsing University

    发明人： CHEN, Jenq-Shyong ,  WANG, Hao-Tang

    IPC分类号： B23Q1/00 ,  B23B37/00 ,  B24B1/04 ,  B23Q1/34

    摘要： A high frequency vibration spindle system (100, 200, 300) which includes a spindle (10, 210, 310) having a spindle housing (12) and a spindle shaft (14, 214, 314) disposed in the spindle housing (12); a tool holder (20, 220, 320), engaged with the spindle (10, 210, 310) and adapted to be engaged with a tool (21); an electric power transmission device (40, 240, 340) disposed at the front end or a rear end of the spindle (10, 210, 310), including a first coil (41, 241, 341) and a second coil (42, 242, 342); the first coil (41, 241, 341) is disposed on the spindle housing (12), and the second coil (42, 242, 342) is disposed on the spindle shaft (14, 214, 314) to be rotated with the spindle shaft (14, 214, 314) coaxially; the first coil (41, 241, 341) and the second coil (42, 242, 342) are spaced with a gap; the second coil (42, 242, 342) is adapted to receive an electric power from the first coil (41, 241, 341) with a non-contact induction method; and a transducer (30, 230, 330), adapted to be controlled to vibrate the tool (21) and disposed in the toolholder (20, 220, 320) and electrically connected with the second coil (42, 242, 342) to receive the electric power.

    ACINETOBACTER BAUMANII ANTIGENS AND THE USES THEREOF
    6.
    发明公开
    ACINETOBACTER BAUMANII ANTIGENS AND THE USES THEREOF 审中-公开
    ACERETOBACTER-BAUMANII-ANTIGENE UND VERWENDUNGEN DAVON

    公开(公告)号：EP3103471A2

    公开(公告)日：2016-12-14

    申请号：EP16173055.1

    申请日：2016-06-06

    申请人： National Chung Hsing University

    发明人： Yang, Chiou-Ying

    IPC分类号： A61K39/00 ,  A61K39/05 ,  C07K16/12 ,  C07K14/21

    CPC分类号： A61K39/0208 ,  A61K39/05 ,  C07K14/22 ,  C07K16/1214 ,  C07K16/1217 ,  C07K2317/73 ,  G01N33/56911 ,  G01N2333/22 ,  G01N2469/10

    摘要： The present invention relates to an isolated polypeptide antigen of Acinetobacter baumannii, comprising at least an amino acid sequence selected from the group consisting of: (a) SEQ ID NOs: 1-5; (b) an amino acid sequence having at least 80% sequence identity to SEQ ID NOs: 1, 3, 4 or 5; (c) an amino acid sequence having at least 60% sequence identity to SEQ ID NO: 2; and (d) a fragment of the amino acid sequence according to (a) to (c); wherein the polypeptide having the amino acid sequence according to (b) to (d) has immunostimulatory activity. The universal polypeptide antigens of Acinetobacter baumannii can be used in the universal vaccine preparation. The corresponding antibodies can be used in the diagnostic and treatment of Acinetobacter baumannii.

    摘要翻译： 本发明涉及鲍氏不动杆菌的分离的多肽抗原，其包含至少一种选自以下的氨基酸序列：（a）SEQ ID NO：1-5; （b）与SEQ ID NO：1,3,4或5具有至少80％序列同一性的氨基酸序列; （c）与SEQ ID NO：2具有至少60％序列同一性的氨基酸序列; 和（d）根据（a）至（c）的氨基酸序列的片段; 其中具有根据（b）至（d）的氨基酸序列的多肽具有免疫刺激活性。 鲍曼不动杆菌的普遍多肽抗原可用于通用疫苗制备。 相应的抗体可用于诊断和治疗鲍氏不动杆菌。