公开(公告)号：EP1764181B1

公开(公告)日：2009-07-29

申请号：EP06026579.0

申请日：2003-02-27

申请人： Osmotica Corp.

发明人： Faour, Joaquina

IPC分类号： B23K26/00 ,  B23K26/08 ,  B23K26/38 ,  B65G47/14 ,  A61K9/00 ,  B65B57/10 ,  B65G47/19 ,  B07C5/02

CPC分类号： B23K26/0006 ,  B23K26/032 ,  B23K26/08 ,  B23K26/0823 ,  B23K26/382 ,  B23K26/389 ,  B23K26/40 ,  B23K2201/35

公开(公告)号：EP1246612B1

公开(公告)日：2008-06-11

申请号：EP01900942.2

申请日：2001-01-08

申请人： Osmotica Corp.

发明人： FAOUR, Joaquina ,  RICCI, Marcelo, A.

IPC分类号： A61K9/22 ,  A61K9/24 ,  A61K9/44 ,  A61K31/137 ,  A61K31/445

CPC分类号： A61K31/505 ,  A61K9/0004 ,  A61K9/209 ,  A61K31/40 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/54 ,  A61K31/55 ,  A61K31/135 ,  A61K2300/00

摘要： The present invention provides an osmotic device containing controlled release pseudoephedrine in the core in combination with a rapid release H1 antagonist in an external coat. A wide range of H1 antagonist antihistamines, especially fexofenadine, can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray coated rather than compression coated onto the device. The device with spray coated external core is smaller and easier to swallow than the similar device having a compression coated external coat. The device is useful for the treatment of respiratory congestion related disorders and allergy related disorders. The present devices provide PS and an H1 antagonist according to specific release profiles in combination with specific formulations.

公开(公告)号：EP1452263A1

公开(公告)日：2004-09-01

申请号：EP03004429.1

申请日：2003-02-27

申请人： Osmotica Corp.

发明人： Faour, Joaquina

IPC分类号： B23K26/00 ,  B23K26/08 ,  B23K26/38 ,  B65G47/14 ,  A61K9/00 ,  B65B57/10 ,  B65G47/19 ,  B07C5/02

CPC分类号： B23K26/0006 ,  B23K26/032 ,  B23K26/08 ,  B23K26/0823 ,  B23K26/382 ,  B23K26/389 ,  B23K26/40 ,  B23K2201/35

摘要： The present invention provides a laser drilling system (20) for drilling holes or cavities in a solid, in particular a solid dosage form. The system includes a loading zone (66), firing zone (30), inspection zone (29,31) and delivery zone (32). The system (20) also includes optional components such as a process validation system (22), solids detector, color detector, solids rejection/repositioning means, accepted products receptacle, rejected products receptacle and/or solids inspection system. Operation of the laser device in the firing zone (30) and of other optional equipment is synchronized with movement of a continuous solids indexer by way of an electronic synchronizer. A solids handling system includes an optional fill level detector that directly or indirectly controls solids loading means that fills a solids reservoir. The system can be run continuously, semicontinuously or batchwise. A solids rejection system in the system provides for reduced solids loss as compared to other laser drilling systems and solids recovery rates of 100% can be achieved.

摘要翻译： 本发明提供一种用于在固体，特别是固体剂型中钻孔或空腔的激光钻孔系统（20）。 该系统包括装载区域（66），燃烧区域（30），检查区域（29,31）和输送区域（32）。 系统（20）还包括可选组件，例如过程验证系统（22），固体检测器，颜色检测器，固体排斥/重新定位装置，接受的产品容器，拒收产品容器和/或固体检查系统。 燃烧区域（30）和其他可选设备中的激光装置的操作与通过电子同步器的连续固体分度器的运动同步。 固体处理系统包括可选的填充液位检测器，其直接或间接地控制填充固体储存器的固体装载装置。 系统可连续运行，半连续运行或间歇运行。 与其他激光钻孔系统相比，系统中的固体排除系统提供了减少的固体损失，并且可以实现100％的固体回收率。

公开(公告)号：EP1246613A1

公开(公告)日：2002-10-09

申请号：EP01901848.0

申请日：2001-01-08

申请人： Osmotica Corp.

发明人： FAOUR, Joaquina ,  COPPARI, Marcelo, A.

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： The delivery devices (20) described herein are capable of delivering one or more active substances by osmotic pumping through preformed passageways (26, 27). An osmotic device according to the invention includes a first osmotic device enclosed within a second osmotic device. The first osmotic device includes drug-containing core (25) surrounded by a first semipermeable membrane (24). The second osmotic device includes a drug-containing composition (23) surrounding the first semipermeable membrane and a second semipermeable membrane (22) surrounding the drug-containing composition. The device can also include an external drug-containing composition (21). In some embodiments, the semipermeable membrane of one or both of the osmotic devices completely dissolves or degrades during use. This delivery device can include an immediate release outer coat.

公开(公告)号：EP1970055A2

公开(公告)日：2008-09-17

申请号：EP06848803.0

申请日：2006-12-20

申请人： Osmotica Corp.

发明人： TONEGUZZO, Fernando, G. ,  MEYER, Glenn, A. ,  RICCI, Marcelo, A. ,  COPPARI, Marcelo, A. ,  PASTINI, Ana, C. ,  FISCHBEIN, Gustavo, A.

IPC分类号： A61K9/24 ,  A61P25/00

CPC分类号： A61K9/209 ,  A61K9/0004

摘要： This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet (1) comprising two external drug-containing layers (2 and 3) in stacked arrangement with respect to and on opposite sides of an oral dosage form (4) that provides a triple combination release of at least one active agent. In one embodiment of the invention the dosage form is an osmotic device. In another embodiment of the invention the dosage form is a gastro-resistant coated core. In yet another embodiment of the invention the dosage form is a matrix tablet. In a different embodiment the dosage form is a hard capsule.

摘要翻译： 本发明涉及用于将活性剂释放到使用环境的三重组合的多层片剂。 更具体地，本发明涉及一种多层片剂（1），其包含两个外用药物层（2和3），所述两个外用药物层相对于口服剂型（4）和/或其两侧堆叠布置，其提供三重组合 释放至少一种活性剂。 在本发明的一个实施方案中，剂型是渗透装置。 在本发明的另一个实施方案中，剂型是耐胃包被的核心。 在本发明的另一个实施方案中，剂型是基质片剂。 在不同的实施方案中，剂型是硬胶囊。

公开(公告)号：EP1834638A1

公开(公告)日：2007-09-19

申请号：EP05857295.9

申请日：2005-12-02

申请人： Osmotica Corp.

发明人： Meyer, Glenn A. ,  Feleder, Ethel C. ,  Ricci, Marcelo A. ,  Coppari, Marcelo A. ,  Befumo, Marcelo E. ,  Faour, Joaquina ,  Vergez, Juan A.

IPC分类号： A61K31/13 ,  A61K9/20 ,  A61K9/28

CPC分类号： A61K31/13 ,  A61K9/0004 ,  A61K9/2009 ,  A61K9/2866

摘要： The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.

摘要翻译： 本发明的渗透装置含有包含金刚烷胺和渗透盐的盐的单一核心，其中两种盐具有共同的离子。 金刚烷胺的释放速率通过增加器件芯体中渗透盐的量从一级释放曲线修改为零级，伪零级或S形释放曲线。 渗透装置包括具有受控孔隙率的半透膜，其可以根据需要进行调整，以与渗透盐配合以提供预定的药物释放曲线。 渗透盐不需要涂覆，并且与金刚烷胺盐混合。

公开(公告)号：EP1764180A1

公开(公告)日：2007-03-21

申请号：EP06026578.2

申请日：2003-02-27

申请人： Osmotica Corp.

发明人： Faour, Joaquina

IPC分类号： B23K26/00 ,  B23K26/08 ,  B23K26/38 ,  B65G47/14 ,  A61K9/00 ,  B65B57/10 ,  B65G47/19 ,  B07C5/02

CPC分类号： B23K26/0006 ,  B23K26/032 ,  B23K26/08 ,  B23K26/0823 ,  B23K26/382 ,  B23K26/389 ,  B23K26/40 ,  B23K2201/35

摘要： The present invention provides a laser-drilling system comprising a) a laser device (21) that directs a pulsing laser beam at a firing zone (30); b) a solids handling assembly comprising: c) a first solids reservoir; d) a continuous solids indexer (69) comprising plural solids-receiving slots (68); e) a containment assembly comprising an undrilled-solids loading zone (66) and a drilled-solids delivery zone (32); f) a solids detector (60) in a first detection zone (29) between the loading zone (66) and the firing zone (30); and g) a color detector (61) in the first detection zone (29) to detect the color of the surface of a solid in a solids receiving slot (68); wherein: the indexer (69) transports a solid from the solids reservoir through a first detection zone (29) and then the firing zone (30) to a delivery zone (32), and the laser device (21), in synchronization with the solids indexer (69) and the solids detector (60), drills one or more holes or cavities in the surface of the solid; and the solids detector (60) detects the presence of a solid in a solids receiving slot (68) of the indexer (69) by means other than the pulsing laser beam of the laser device (21).

摘要翻译： 本发明提供了一种激光钻孔系统，其包括：a）激光装置（21），其将脉冲激光束引导到点火区域（30）; b）固体处理组件，其包括：c）第一固体储存器; d）包括多个固体接收槽（68）的连续固体分级器（69）; e）容纳组件，其包括未固体填充物填充区（66）和钻井固体输送区（32）; f）在装载区域（66）和燃烧区域（30）之间的第一检测区域（29）中的固体检测器（60）; 以及g）第一检测区域（29）中的颜色检测器（61），以检测固体接收槽（68）中的固体的表面的颜色; 其中：所述分度器（69）将来自所述固体储存器的固体通过第一检测区域（29），然后将所述点火区域（30）输送到输送区域（32），并且所述激光装置（21）与 固体分度器（69）和固体检测器（60）钻出固体表面中的一个或多个孔或空腔; 并且所述固体检测器（60）通过所述激光装置（21）的脉冲激光束以外的装置来检测所述分度器（69）的固体接收槽（68）中是否存在固体。

公开(公告)号：EP1248598A1

公开(公告)日：2002-10-16

申请号：EP01901878.7

申请日：2001-01-08

申请人： Osmotica Corp.

发明人： FAOUR, Joaquina

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： The present invention provides a simple and improved osmotic device (1) that is capable of providing a controlled release of active agent contained in the core (4) through a preformed passageway (5) into an environment of use. The preformed passageway (5) increases in size during use of the osmotic device (1) thereby increasing the release rate of the active agent, enabling the release of large particles containing active agent, and enabling the release of active agents that are substantially insoluble in the environment of use.

公开(公告)号：EP1714641B8

公开(公告)日：2010-05-19

申请号：EP05850136.2

申请日：2005-01-03

申请人： Osmotica Corp.

发明人： FELEDER, Ethel C. ,  MEYER, Glenn A. ,  RICCI, Marcelo A. ,  BEFUMO, Marcelo F. ,  FAOUR, Joaquina ,  PASTINI, Ana C.

IPC分类号： A61K9/32 ,  A61K31/137

CPC分类号： A61K9/0004 ,  A61K31/13 ,  A61K31/137 ,  A61K31/277

公开(公告)号：EP2070518A2

公开(公告)日：2009-06-17

申请号：EP07817380.4

申请日：2007-07-24

申请人： Osmotica Corp.

发明人： FAOUR, Joaquina ,  PASTINI, Ana C.

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/36

CPC分类号： A61K9/0048 ,  A61K9/08

摘要： Aqueous ophthalmic solutions containing a combination of hyaluronic acid or a pharmaceutically acceptable salt thereof, e.g. sodium hyaluronate, and polyvinyl alcohol are disclosed. These solutions have a synergistic effect on viscosity and provide a statistically significant improvement over the prior art formulations. The solutions are used as artificial tear for the treatment of dry eye syndrome and ocular discomfort and may be administered whenever the use of artificial tears is advisable. The solutions are also suitable for use as vehicle for ophthalmic drugs.

摘要翻译： 含有透明质酸或其药学上可接受的盐的组合的水性眼用溶液，例如， 透明质酸钠和聚乙烯醇。 这些溶液对粘度具有协同效应，并提供比现有技术制剂统计学显着的改进。 该溶液被用作治疗干眼综合征和眼部不适的人造泪液，并且可以在使用人造泪液时施用。 该溶液也适合用作眼科药物的载体。