PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF
    8.
    发明公开
    PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF 审中-公开
    MITTEL ZUR PROTEIN- UNDNUKLEINSÄUREABGABESOWIE KOMPONENTEN DAVON UND MECHANISMEN DAMIT

    公开(公告)号:EP2542681A4

    公开(公告)日:2013-10-16

    申请号:EP11765160

    申请日:2011-04-08

    发明人: RAO VENIGALLA

    摘要: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.

    摘要翻译: 复杂的病毒通过顺序和不可逆的组装从简单的蛋白质亚基组装而成。 在噬菌体的基因组包装过程中,一个强大的分子马达组装在一个空的prohead的特定入口顶点以启动包装。 本发明的一个方面涉及高度混杂的噬菌体T4包装机器,将DNA转移至完成的噬菌体头部和头部。 单电动机可以将外源DNA强制进入噬菌体头部,其进入噬菌体头部的速度相同,并且噬菌体头部经历反复启动,将多个DNA分子包装到相同的头部。 这表明噬菌体DNA包装机具有不同寻常的构象可塑性,将DNA驱动到明显被动的衣壳容器中,包括高度稳定的病毒壳,直到它充满。 这些特征允许设计一类新型纳米壳运载工具。

    PROTECTION OF LIVING SYSTEMS FROM ELECTROMAGNETIC FIELDS
    10.
    发明公开
    PROTECTION OF LIVING SYSTEMS FROM ELECTROMAGNETIC FIELDS 失效
    万物的电磁场保护

    公开(公告)号:EP0863728A4

    公开(公告)日:2000-11-08

    申请号:EP95940015

    申请日:1995-11-28

    IPC分类号: A61B19/00 A61N1/16

    摘要: Methods and apparatus for inhibiting the adverse effect of an ambient time varying field having an electric component and/or a magnetic component on a living system. To provide protection, the field to which the system is exposed is caused to be one wherein at least one of the characteristic parameters of said field to which the living system is exposed is changed within time intervals of less than 10 seconds. The strength of the field to which the living system is to be exposed is controlled as a function of the strength of the ambient field. Living systems which are benefitted include humans.