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1.发明公开ASYMMETRIC LIPOSOMES AND USES IN MEDICAL FIELD THEREOF 审中-公开不寻常的LIPOSOME UND IHRE VERWENDUNG在DER MEDIZIN
公开(公告)号：EP2178602A2
公开(公告)日：2010-04-28
申请号：EP08790061.9
申请日：2008-07-15
CPC分类号： A61K9/127 , A61K9/0073 , A61K47/6911
摘要： The invention concerns new asymmetric liposomes and uses thereof in medical field transport lipids involved in antimicrobial or antiviral response, particularly at level of pulmonary target cells.
摘要翻译： 本发明涉及新的不对称脂质体及其在医学领域中用于转运涉及抗微生物或抗病毒反应的脂质，特别是在肺靶细胞水平。
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公开(公告)号：EP1932852A8
公开(公告)日：2008-10-29
申请号：EP06026026.2
申请日：2006-12-15
CPC分类号： C07K14/4747 , C07K7/02 , C07K7/06 , C07K14/70567
摘要： The present invention relates to peptides mimicking the pro-apoptotic effects of taxane antitumor agent paclitaxel.
摘要翻译： 本发明涉及模拟紫杉烷抗肿瘤剂紫杉醇的促凋亡作用的肽。
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公开(公告)号：EP1610667B1
公开(公告)日：2007-09-26
申请号：EP03720862.6
申请日：2003-04-04
CPC分类号： A61B1/018 , A61B1/0051 , A61B1/04
摘要： An endoscopic instrument (10), particularly useful for the non-invasive treatment of some digestive system pathologies, has a flexible and elongate main body (11) that houses a vision device (22) for taking images of an organ internal area, comprising a first working arm (21) for the use of tools, and further comprises a second working arm (23) for the use of tools apt to be operated independently with respect to said first working arm (21), allowing an endoscopic treatment of a wide range of pathologies that at present are treatable only surgically.
摘要翻译： 特别可用于一些消化系统病变的非侵入性治疗的内窥镜器械（10）具有柔性和细长的主体（11），其容纳用于拍摄器官内部区域的图像的视觉装置（22），其包括 用于使用工具的第一工作臂（21），并且还包括用于使用易于相对于所述第一工作臂（21）独立操作的工具的第二工作臂（23），允许内窥镜处理宽 目前只能手术治疗的病理范围。
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5.发明公开TCR/MHCII-COLLAGEN INTERACTION INHIBITORS USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS 有权TCR / MHCII-COLLAGEN-INTERAKTIONSINHIBITOREN ZUR BEHANDLUNG VON RHEUMATOIDER ARTHRITIS
公开(公告)号：EP2831041A2
公开(公告)日：2015-02-04
申请号：EP13724389.5
申请日：2013-04-02
发明人： DE ROSA, Maria Cristina , RIA, Francesco , GIARDINA, Bruno , FERRACCIOLI, Gianfranco , PIROLLI, Davide , NICOLO', Chiara
IPC分类号： C07D207/06 , C07D207/08 , C07D209/86 , C07D209/88 , C07D307/91 , C07D401/04 , C07D409/12 , C07C251/88 , A61K31/175 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/435
CPC分类号： C07D209/86 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4439 , C07C251/86 , C07C2603/18 , C07D207/06 , C07D207/08 , C07D209/88 , C07D307/91 , C07D401/04 , C07D407/12 , C07D409/12
摘要： The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen ll-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.
摘要翻译： 特异于人胶原II型的T细胞是可能的自身抗原之一，在HLA-DR4的上下文中对类风湿性关节炎的发展起着至关重要的作用。 与HLA-DR4类HLA-DR4等位基因MHC连接的T细胞受体（TCR）和II型胶原之间的蛋白质 - 蛋白质相互作用因此可能代表了针对类风湿关节炎的新药开发的目标。 使用计算虚拟筛选技术，已经鉴定出干扰TCR /胶原II-MHCII相互作用的药理活性分子家族。 这些化合物在治疗类风湿性关节炎方面开辟了新的可能性。
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6.发明公开PREDICTIVE EVALUATION OF THE RESPONSE TO TAXANE-INCLUDING CHEMOTHERAPY 审中-公开PRETIKTIVE BEURTEILUNG DES ANSPRECHENS AUF EINE CHEMOTHERAPIE MIT TAXAN
公开(公告)号：EP2443452A1
公开(公告)日：2012-04-25
申请号：EP09779795.5
申请日：2009-06-16
IPC分类号： G01N33/50
CPC分类号： G01N33/5011 , G01N2800/52
摘要： The present invention relates to methods and kits for a predictive evaluation of the effectiveness of a taxane-including treatment of a tumour or of cancer cells.
摘要翻译： 本发明涉及用于预测评估包括治疗肿瘤或癌细胞的紫杉烷的有效性的方法和试剂盒。
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公开(公告)号：EP2073724B1
公开(公告)日：2011-04-20
申请号：EP07826302.7
申请日：2007-09-07
IPC分类号： A61B17/11
CPC分类号： A61B17/1128
摘要： A neural guide (1) apt to receive a pair of nerve stumps (N1, N2) to allow nerve regeneration therethrough, comprising a first (2) and a second half-shell member (3) closeable the one on the other so as to define therebetween a longitudinal seat (4) having a cylindrical geometry, said seat having a widened central section (43) for nerve regeneration and two spherical side sections (44, 45) for making the gluing points
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8.发明公开
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公开(公告)号：EP3157590B1
公开(公告)日：2020-04-15
申请号：EP15741332.9
申请日：2015-06-18
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10.发明公开INJECTABLE APATITIC CEMENT IONICALLY MULTI-SUBSTITUTED FOR REGENERATIVE VERTEBROPLASTY AND KYPHOPLASTY 审中-公开注射用复方替代治疗复发性脊柱侧凸和KYOPOPLASTY的注射用可溶性水泥
公开(公告)号：EP3157590A1
公开(公告)日：2017-04-26
申请号：EP15741332.9
申请日：2015-06-18
摘要： An injectable apatite cement, in which the calcium in the a phase is partially substituted with strontium, and in which tricalcium phosphate in the β phase is also present is described. Also described is a method for its preparation and its use in bone regeneration, in particular in vertebroplasty, in kyphoplasty, and in pathologies characterized by a loss of bone substance.
摘要翻译： 描述了一种可注射的磷灰石水泥，其中a相中的钙被锶部分取代，并且其中还存在β相中的磷酸三钙。 还描述了其制备方法及其在骨再生中的用途，特别是在椎体成形术中，椎体后凸成形术中以及以骨物质损失为特征的病理学中的用途。
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