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公开(公告)号：EP0222617A2
公开(公告)日：1987-05-20
申请号：EP86308785.4
申请日：1986-11-12
IPC分类号： A61K39/395 , A61K45/06 , A61K49/02
CPC分类号： C07K16/2809 , A61K39/395 , A61K51/1042 , A61K2123/00 , Y10S424/804 , Y10S424/81 , Y10S514/885 , A61K2300/00
摘要： A method of seriatim administration to a patient of a plurality of ligands, each of which contains an antigen combining site of a monoclonal antibody of distinct idiotype, is disclosed. This method is useful for therapeutic as well as diagnostic purposes.
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2.发明公开
公开(公告)号：EP1187637A2
公开(公告)日：2002-03-20
申请号：EP00942678.4
申请日：2000-06-07
CPC分类号： B82Y5/00 , A61K47/6893 , A61K51/1042 , A61K51/1045 , A61K51/1096
摘要： The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta- emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient.
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公开(公告)号：EP0222617A3
公开(公告)日：1989-08-23
申请号：EP86308785.4
申请日：1986-11-12
IPC分类号： A61K39/395 , A61K45/06 , A61K49/02
CPC分类号： C07K16/2809 , A61K39/395 , A61K51/1042 , A61K2123/00 , Y10S424/804 , Y10S424/81 , Y10S514/885 , A61K2300/00
摘要： A method of seriatim administration to a patient of a plurality of ligands, each of which contains an antigen combining site of a monoclonal antibody of distinct idiotype, is disclosed. This method is useful for therapeutic as well as diagnostic purposes.
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公开(公告)号：EP3322735A1
公开(公告)日：2018-05-23
申请号：EP16823604.0
申请日：2016-07-15
申请人： Zymeworks Inc.
CPC分类号： A61K47/6803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6811 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6869 , A61K51/1027 , A61K51/103 , A61K51/1042 , A61K51/1051 , A61K51/1072 , A61K2039/505 , A61K2039/572 , A61P35/00 , A61P35/02 , A61P35/04 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/32 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C40B40/02 , C40B40/08
摘要： Bispecific antigen-binding constructs e.g., antibodies conjugated to drugs (ADCs), which bind CD3 and other cell-surface target antigen such as tumor antigens e.g., CD19, CDH3, HER2, HER3 and EGFR antigens and methods of use are disclosed.
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公开(公告)号：EP3297671A2
公开(公告)日：2018-03-28
申请号：EP16797161.3
申请日：2016-05-17
发明人： WONG, Brian , MASTELLER, Emma , LIU, Cheng , XU, Yiyang , LIU, Hong , YAN, Su , XIANG, Jingyi , WANG, Pei
IPC分类号： A61K39/395 , C07K16/28 , C12N1/15 , C12N1/21 , G01N33/574
CPC分类号： C07K16/2803 , A61K38/05 , A61K47/6817 , A61K47/6851 , A61K47/6881 , A61K51/1027 , A61K51/1042 , A61K51/1096 , A61K2039/505 , A61P35/00 , A61P35/02 , C07K16/005 , C07K16/2809 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/57492 , G01N2333/912
摘要： The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.
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