专利检索 cpc:"A61L2300/21620130101" 第 1 页

1.

发明公开
DRUG-LOADED BALLOON AND PREPARATION METHOD THEREFOR 审中-实审

公开(公告)号：EP4400126A1

公开(公告)日：2024-07-17

申请号：EP23853678.3

申请日：2023-03-17

申请人： Brosmed Medical Co., Ltd.

发明人： WANG, Liwei , HUANG, Junyi , ZHANG, Zhijun , LI, Bin

IPC分类号： A61L29/08 , A61L29/14 , A61L29/16

CPC分类号： A61L29/049 , A61L29/085 , A61L29/16 , A61L2300/21620130101 , A61L2300/41620130101 , A61L2300/60220130101 , A61L2300/60820130101 , A61L2300/6220130101 , A61L2420/0220130101 , A61L2420/0620130101 , A61L2300/6320130101

摘要： A drug coated balloon and a preparation method thereof are provided. The drug coated balloon includes a balloon body and a drug loaded coating layer. The drug loaded coating layer includes a first drug loaded coating component having at least two controllable sustained release drugs with different drug release kinetics, and a second drug loaded coating component including an active drug in a free unbound form. The second drug loaded coating component is dispersed among the controllable sustained release drugs in the first drug loaded coating component and couples the controllable sustained release drugs on the balloon body. The first and second drug loaded coatings component are both non-hydrophilic compositions. The drug coated balloon can provide sufficient initial drug loading dosage to the lesion site, and multiple controllable sustained release drugs having different drug release kinetics is able to avoid explosive drug release and extinction. The drug release rate can also be regulated through different combinations, thereby allowing the drug coated balloon to provide bioactive drugs to the treatment site at different stages of the cascade reaction of vascular restenosis, providing the controllable long-acting therapeutic drugs to the lesion site, and improving the overall vascular drug release efficacy.