摘要:
The invention provides in one aspect a drug delivery device comprising a drug container (16), and a plunger (18) positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source (42) operable to apply pressure on the plunger or the drug container to pressurise the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurised. In another aspect, there is provided a drug delivery device comprising a housing, including an external housing portion configured to be held in use and a drug containing portion containing a drug, a needle assembly comprising a needle fixed to a needle hub, the needle hub configured to move relative to the drug containing portion from an initial position within the housing to an insertion position in which the needle extends beyond the housing, a first stored energy source configured to move the needle hub from the initial position to the insertion position, and a plunger within the housing and configured to move relative to the drug containing portion to eject the drug through the needle when the needle is in the insertion position.
摘要:
A method of manufacture for a drug cartridge assembly. The method includes providing a drug cartridge, providing a nozzle sub-assembly, and sterilizing the drug cartridge and nozzle sub-assembly. The method further includes assembling the drug cartridge and nozzle sub-assembly together in a configuration that enables ejection of liquid out of the drug cartridge through the nozzle sub-assembly. The method further includes filling the drug cartridge with a liquid, such as an injectable drug. The method may include separate sterilization of the drug cartridge and nozzle sub-assembly, using different sterilization processes. Portions of the method may be performed prior to sterilization within a first cleanroom, with subsequent steps being performed in a second cleanroom having a substantially lower particulate-per-volume rating than the first cleanroom.
摘要:
The invention relates to an injector device for delivery of liquid from a high pressure source, and also to a method of performing such an injection. The device comprises a storage chamber (6), for the liquid or the liquid precursor components, comprising a storage barrel (16) with at least a section of substantially constant cross-section, defining a storage chamber axis, and a pressure chamber (4) comprising a pressure barrel (10) of substantially constant cross-section, defining a pressure chamber axis, for accommodation of at least one piston therein and having a front end opening (14) for ejection of the liquid. The pressure chamber being of sufficient strength to sustain the liquid pressure. The chambers are separate parts and adapted to cooperate with each other during injection so that the pressure chamber axis and the storage chamber axis substantially coincide, and that the pressure barrel and storage barrel have internal diameters sufficiently similar to allow passage of a resilient piston from the storage barrel to the pressure barrel in a sealing manner. The liquid is transferred from the storage chamber directly into the delivery chamber when the jet injection is to be performed.
摘要:
Seringue préremplie comprenant un réservoir contenant une dose unitaire de médicament à injecter. Les éléments principaux de cette seringue sont le réservoir (10), un organe d'obturation (12), une capsule (13) solidaire de cet organe, une aiguille (14), un cache-aiguille (15) et un capuchon (16). Le capuchon (16), en place sur le réservoir, permet à l'opérateur, en appuyant sur ce capuchon de faire pénétrer l'organe d'obturation vers l'intérieur du réservoir d'une distance suffisante pour provoquer le débullage précis de la seringue. Dans ce but, le capuchon est lié à la capsule (13) par une embase (36) comportant une zone de moindre résistance.
摘要:
A system for dispensing a non-user settable dose of one medicament and a user-settable dose of a primary medicament. The system includes a medicated module attachable to a drug delivery device, the drug delivery device having a drug reservoir holding a first medicament. The medicated module includes a first needle (206), a second needle (208), a collapsible feature (210) holding a second medicament, a biasing feature (214) operably connected to the collapsible feature, and a valve system (216) having a closed position and an open position. During dispense, the valve system transitions from the closed position to the open position, and the biasing feature compresses the collapsible feature to force the second medicament to flow from the collapsible feature to the second needle.
摘要:
A device (1) is proposed for placing a stopper (17) while simultaneously checking that the stopper (17) is correctly positioned, with a retaining element for securing a hollow body (15) which has a first opening and a second opening (21, 25), and with a stopper-placing means (27) with which the stopper (17) can be introduced into the second opening (25) in the hollow body (15). The device (1) is distinguished by a measuring head (5) through which at least one passage (11) passes, wherein the passage (11) can be brought into fluidic connection with the first opening (21) in the hollow body (15), and by a pressure transducer (3) which can be brought into fluidic connection with the passage (11) in the measuring head (5).
摘要:
The invention relates to a twin-chamber receptacle for accommodating and combining two separate components, at least one of which is liquid. Said twin-chamber receptacle comprises a cylindrical member (15) with one respective closure (20, 60) at each of the two ends (5, 70) of the member (15). The closure (60) located on the side of the chamber (5) containing the liquid component can be displaced by applying pressure. The twin-chamber receptacle further comprises a separating plug (40) which is disposed in the cylindrical member (15), defines the volume of the chamber (30, 50) located above and below, is used as a seal between the two chambers (30, 50), and can be displaced only when a greater amount of pressure is applied. The separating plug is provided with a continuous hole (42) which extends along the longitudinal axis of the separating plug (40) and encompasses a top section (42a) and a bottom section (42b). The top section (42a) of the hole (42) is closed in a liquid-tight manner towards the chamber (50) containing the liquid component by means of a molded element (45) that can be displaced by applying a small to a moderate amount of pressure.
摘要:
A gas-powered, single-use, needle-less hypodermic jet injection device (10, 210, 410) includes a hand-held injector (12, 212, 412), and a drug injection cartridge (14, 114, 414) which provides a volume of liquid medication to be injected, an injection orifice, and an injection piston. Forceful movement of the injection piston causes an injection jet of medication to be expelled from the injection orifice. The injection device also inlcudes a hermetically sealed gas pressure cartridge (82, 182, 482) which remains sealed until the moment of injection and powers the jet injection after opening of this cartridge.
摘要:
A drug delivery device includes a container for storing a drug, the container having a stopper for expelling the drug; an injection drive comprising an energy source for directly or indirectly acting on the stopper to expel the drug; a sensor for detecting contact between the drug delivery device and a body of a patient; and a user interface (UI) for activating or causing the activation of the injection drive. The device is operative for drawing attention to the UI, if the sensor detects contact between the drug delivery device and the body of the patient, to thereby indicate that the injection drive is ready to be activated, which activation is the next step in the drug administration process.