公开(公告)号：EP4344736A3

公开(公告)日：2024-07-03

申请号：EP23211269.8

申请日：2018-06-22

申请人： RefleXion Medical, Inc.

发明人： OWENS, Michael Kirk ,  BASSALOW, Rostem ,  OLCOTT, Peter Demetri ,  VORONENKO, Yevgen ,  LARKIN, David Quentin ,  MAZIN, Samuel

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/1037 ,  A61N5/1067 ,  A61N5/1036 ,  A61N5/1049 ,  A61N2005/105520130101 ,  A61N5/1039 ,  A61N5/1045 ,  A61N2005/105220130101 ,  A61N2005/105820130101 ,  A61N5/1038

摘要： Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

公开(公告)号：EP3197553B1

公开(公告)日：2018-03-21

申请号：EP15774984.7

申请日：2015-09-09

申请人： Koninklijke Philips N.V.

发明人： VIK, Torbjoern ,  HEESE, Harald Sepp ,  BYSTROV, Daniel ,  WEESE, Juergen ,  NEUKIRCHEN, Christoph ,  ISOLA, Alfonso Agatino ,  BAL, Matthieu Frederic

IPC分类号： A61N5/10

CPC分类号： A61N5/1036 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1045 ,  G06F19/3456 ,  G16H50/30

摘要： A radiation planning system includes a predictor-corrector optimizer unit which computes a predicted dose based on a collection of control points with a current approximate dose, each control point with a corresponding set of leaf positions, and determines an additional control point with a corresponding set of leaf positions based on a difference of the predicted fluence and the current approximate fluence through a least cost or shortest path in a layered graph structure of realizable leaf positions. Tools are described to help a planner to evaluate the effect of parameter changes to the current plan based on an identified zone of influence. The planner interactively views the current plan based on a visualization of the plan objectives and correlations between the objectives.

公开(公告)号：EP3003483A1

公开(公告)日：2016-04-13

申请号：EP14725093.0

申请日：2014-05-14

申请人： Koninklijke Philips N.V. ,  Philips GmbH

发明人： ISOLA, Alfonso Agatino ,  NEUKIRCHEN, Christoph ,  WEESE, Juergen ,  BAL, Matthieu Frédéric

IPC分类号： A61N5/10

CPC分类号： A61N5/1036 ,  A61N5/1045 ,  A61N5/1047 ,  A61N2005/1074

摘要： The invention relates to a device for determining illumination distributions (18) for IMRT. A layered graph structure is used, which considers which extensions of an illumination distribution along a respective line and thus which illumination distributions are realizable, for determining extensions for the illumination distributions. Moreover, second weights defining fluences of the illumination distributions are determined such that a deviation between a provided fluence map and a fluence map formed by a combination of illumination distributions, which are defined by the respective determined extensions and the respective second weight, is minimized. This determination procedure leads to illumination distributions, which very well correspond to the provided fluence map and which are automatically realizable by the radiation device. This leads to an improved IMRT, wherein a post-processing of the determined illumination distributions for ensuring that the determined illumination distributions are really realizable is not necessarily required.

摘要翻译： 本发明涉及一种用于确定IMRT的照明分布（18）的装置。 使用分层图结构，其考虑沿着相应线的照明分布的哪些延伸，并且因此考虑哪些照明分布是可实现的，以确定用于照明分布的扩展。 此外，确定照明分布的通量的第二权重被确定为使得由所确定的扩展和相应的第二权重定义的由照明分布的组合形成的所提供的注量图与通量密度图之间的偏差最小化。 该确定程序导致照明分布，其非常对应于所提供的注量图并且可由辐射装置自动实现。 这导致改进的IMRT，其中对确定的确定的照明分布真正可实现的所确定的照明分布的后处理不一定是必需的。

公开(公告)号：EP2994195A2

公开(公告)日：2016-03-16

申请号：EP14723886.9

申请日：2014-04-17

申请人： Koninklijke Philips N.V.

发明人： RANGANATHAN, Vaitheeswaran ,  JOE ANTO, Gipson ,  KUMAR, Prashant ,  KRISHNAIYER RAMAN, Sivaramakrishnan ,  MAHAJAN, Deepak Uddhavrao

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1077 ,  A61N2005/1074 ,  G06F19/00

摘要： A method for dose-gradient based optimization of an intensity modulated radiation therapy plan. First, an optimizer (6) performs a first optimization (40) of the plan to generate dose distributions corresponding to the plan. Next, the optimizer (6) generates a beam specific dose gradient map (42) for each beam of the plan. Then, new dose gradients are specified (44) for the plan. Last, the optimizer (6) performs a final optimization (46) using the new dose gradients. The final optimization is given the new dose gradients as soft constraints into an objective function. The optimizer (3) applies a limiting factor to the objective function such that a first dose gradient is limited by the optimizer only if the first dose gradient exceeds the new dose gradient for a specific beamlet.

公开(公告)号：EP2782642A1

公开(公告)日：2014-10-01

申请号：EP11787690.4

申请日：2011-11-23

申请人： Brainlab AG

发明人： VILSMEIER, Stefan

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1077 ,  A61N2005/1087 ,  G06F19/3481 ,  G21K5/00 ,  G21K5/04

摘要： The present invention is directed to a data processing method for determining a treatment plan for radiation therapy treatment of at least two spatially separate targets by means of a treatment device constituted to treat the at least two targets by means of one or more sub-beams during a treatment time, the one or more sub-beams constituting at least one treatment beam which is to pass through the at least two targets in accordance with a treatment plan during the treatment time, the treatment device being further constituted to allow for simultaneous treatment of the at least two targets by at least two of the sub-beams at least during a time interval during the treatment time.

公开(公告)号：EP0904805B1

公开(公告)日：2009-03-25

申请号：EP98307811.4

申请日：1998-09-25

申请人： Siemens Medical Solutions USA, Inc.

发明人： Siochi, Ramon Alfredo

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1036

公开(公告)号：EP4432308A2

公开(公告)日：2024-09-18

申请号：EP24186121.0

申请日：2020-03-27

申请人： Elekta, Inc.

发明人： NEUKIRCHEN, Christoph ,  ISOLA, Alfonso Agatino ,  HEESE, Harald Sepp ,  VIK, Torbjoern ,  WEESE, Rolf Jürgen ,  BAL, Matthieu Frédéric

IPC分类号： G21K1/04

CPC分类号： A61N5/1036 ,  A61N5/1047

摘要： A device for optimizing a radiation therapy plan (30) for delivering therapeutic radiation to a patient using a therapeutic radiation source (16) while modulated by a multi-leaf collimator (MLC) (14) includes at least one electronic processor (25) connected to a radiation therapy device (12). A non-transitory computer readable medium (26) stores instructions readable and executable by the at least one electronic processor to perform a radiation therapy plan optimization method (102) including: optimizing MLC settings of the MLC respective to an objective function wherein the MLC settings define MLC leaf tip positions for a plurality of rows of MLC leaf pairs at a plurality of control points (CPs). The optimizing is performed in two or more iterations with a resolution of the MLC settings increasing in successive iterations.

公开(公告)号：EP3946587B1

公开(公告)日：2024-07-03

申请号：EP20715810.6

申请日：2020-03-27

IPC分类号： A61N5/10 ,  G21K1/04

CPC分类号： A61N5/1036 ,  A61N5/1047

公开(公告)号：EP3300769A3

公开(公告)日：2018-09-19

申请号：EP17197703.6

申请日：2015-09-09

申请人： Koninklijke Philips N.V.

发明人： VIK, Torbjoern ,  HEESE, Harald Sepp ,  BYSTROV, Daniel ,  WEESE, Rolf Jürgen ,  NEUKIRCHEN, Christoph ,  ISOLA, Alfonso Agatino ,  BAL, Matthieu Frédéric

IPC分类号： A61N5/10

CPC分类号： A61N5/1036 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1045 ,  G06F19/3456 ,  G16H50/30

摘要： A radiation planning system includes a predictor-corrector optimizer unit which computes a predicted dose based on a collection of control points with a current approximate dose, each control point with a corresponding set of leaf positions, and determines an additional control point with a corresponding set of leaf positions based on a difference of the predicted fluence and the current approximate fluence through a least cost or shortest path in a layered graph structure of realizable leaf positions. Tools are described to help a planner to evaluate the effect of parameter changes to the current plan based on an identified zone of influence. The planner interactively views the current plan based on a visualization of the plan objectives and correlations between the objectives.

公开(公告)号：EP2792388B1

公开(公告)日：2017-09-20

申请号：EP13002067.0

申请日：2013-04-19

申请人： Scientific RT GmbH

发明人： Sobotta, Benjamin ,  Alber, Markus

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1036 ,  A61N5/1042 ,  A61N5/1047 ,  A61N5/1081 ,  A61N2005/1091 ,  H05K999/00