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1.发明公开INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1194403A1
公开(公告)日：2002-04-10
申请号：EP00940359.3
申请日：2000-06-10
IPC分类号： C07C311/16 , C07D295/22 , C07C311/20 , C07C311/29 , C07C311/21 , C07D217/02 , C07C311/39 , A61K31/18 , A61K31/445
CPC分类号： C07D295/26 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/26 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D217/02
摘要： The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an 'ultra-rapidly activating delayed rectifier' in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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2.发明授权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1194403B1
公开(公告)日：2003-09-03
申请号：EP00940359.3
申请日：2000-06-10
IPC分类号： C07C311/16 , C07D295/22 , C07C311/20 , C07C311/29 , C07C311/21 , C07D217/02 , C07C311/39 , A61K31/18 , A61K31/445
CPC分类号： C07D295/26 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/26 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D217/02
摘要： The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an 'ultra-rapidly activating delayed rectifier' in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
摘要翻译： 其中R（1）到R（8）具有在权利要求中所述的含义，在人的心房作用于对Kv1.5钾通道，和抑制钾电流，通过向称为“超快速激活延迟整流，” ， 它们特别适合用作因此是非常新颖的抗心律失常的活性物质，特别是用于治疗和房性心律失常的预防，E. G.，心房纤维性颤动或心房扑动。
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