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公开(公告)号：EP2578576B9
公开(公告)日：2016-09-14
申请号：EP12191294.3
申请日：2008-10-03
发明人： Chase, Charles , Endo, Atsushi , Fang, Francis, G. , Li, Jing
IPC分类号： C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula:
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2.发明公开PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b) FURAN-3-OL 有权制备（3α，3α/β，6α/ BETA）六氢呋喃并[2,3-b]呋喃-3-醇的立体异构体的
公开(公告)号：EP1532127A1
公开(公告)日：2005-05-25
申请号：EP03762054.9
申请日：2003-06-25
发明人： DOAN, Brian, DanielGlaxoSmithKline , PATTERSON, Daniel, EdwardGlaxoSmithKline , ROBERTS, John, C.GlaxoSmithKline
IPC分类号： C07D307/26 , C07D493/04
CPC分类号： C07D493/04 , C07D307/26
摘要： The present invention provides processes and compounds that are useful in the preparation of (3α, 3aβ, 6aβ)-hexahydrofuro[2,3-b]furan-3-ol and diastereoisomers thereof, which are useful in the preparation of compounds that may be inhibitors of HIV aspartyl protease.
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3.发明授权Intermediates for the synthesis of halichondrin B analogs 有权Zwischenprodukte zur Synthese von Halichondrin-B-Analoga
公开(公告)号：EP2578576B1
公开(公告)日：2016-03-23
申请号：EP12191294.3
申请日：2008-10-03
发明人： Chase, Charles , Endo, Atsushi , Fang, Francis, G. , Li, Jing
IPC分类号： C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula:
摘要翻译： 描述了用于合成软组蛋白B类似物的以下中间体：化合物AU，化合物AR或包含具有下式的化合物的组合物：
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4.发明授权INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS 有权ZWISCHENPRODUKTE UND VERFAHREN ZUR SYNTHESE VON HALICHONDRIN-B-ANALOGA
公开(公告)号：EP2200992B1
公开(公告)日：2014-02-26
申请号：EP08836425.2
申请日：2008-10-03
发明人： CHASE, Charles , ENDO, Atsushi , FANG, Francis, G. , LI, Jing
IPC分类号： C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula:
摘要翻译： 描述了用于合成软组蛋白B类似物的以下中间体：化合物AU，化合物AR或包含具有下式的化合物的组合物：
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公开(公告)号：EP2200992A1
公开(公告)日：2010-06-30
申请号：EP08836425.2
申请日：2008-10-03
发明人： CHASE, Charles , ENDO, Atsushi , FANG, Francis, G. , LI, Jing
IPC分类号： C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula:
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公开(公告)号：EP2578576A1
公开(公告)日：2013-04-10
申请号：EP12191294.3
申请日：2008-10-03
发明人： Chase, Charles , Endo, Atsushi , Fang, Francis, G. , Li, Jing
IPC分类号： C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： The following intermediates for the synthesis of halichondrin B analogs are described:
Compound AU,
Compound AR,
or a composition comprising a compound having the formula:-
7.发明授权PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b) FURAN-3-OL 有权的立体异构体制造（3α，3α/β，6α/ BETA）HEXAHYDROFURO¬2,3-B |呋喃-3-醇
公开(公告)号：EP1532127B1
公开(公告)日：2006-09-27
申请号：EP03762054.9
申请日：2003-06-25
发明人： DOAN, Brian, Daniel GlaxoSmithKline , PATTERSON, Daniel, Edward GlaxoSmithKline , ROBERTS, John, C. GlaxoSmithKline
IPC分类号： C07D307/26 , C07D493/04
CPC分类号： C07D493/04 , C07D307/26
摘要： The present invention provides processes and compounds that are useful in the preparation of (3α, 3aβ, 6aβ)-hexahydrofuro[2,3-b]furan-3-ol and diastereoisomers thereof, which are useful in the preparation of compounds that may be inhibitors of HIV aspartyl protease.
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公开(公告)号：EP1487269A4
公开(公告)日：2005-12-21
申请号：EP03714161
申请日：2003-03-13
申请人： UNIV MONTANA STATE
发明人： LIVINGHOUSE TOM
IPC分类号： C12N15/09 , A01N43/08 , A61K31/365 , A61P31/00 , A61P31/04 , C07D307/26 , C07D307/32 , C07D307/33 , C12N1/00 , A01N37/28 , A61K31/341 , C07D333/04
CPC分类号： C07D307/33 , C07D307/26 , C07D307/32
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公开(公告)号：EP1487269A1
公开(公告)日：2004-12-22
申请号：EP03714161.1
申请日：2003-03-13
发明人： LIVINGHOUSE, Tom
IPC分类号： A01N43/08 , A01N37/28 , C07D307/26 , C07D333/04
CPC分类号： C07D307/33 , C07D307/26 , C07D307/32
摘要： Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed.
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