公开(公告)号：EP2703381A1

公开(公告)日：2014-03-05

申请号：EP12777023.8

申请日：2012-04-27

申请人： Ono Pharmaceutical Co., Ltd.

发明人： HAYASHI, Yujiro

IPC分类号： C07C205/18 ,  C07C201/12 ,  C07C205/44 ,  C07D307/42 ,  C07B53/00 ,  C07B61/00

CPC分类号： C07D307/45 ,  C07B53/00 ,  C07C67/30 ,  C07C69/732 ,  C07C69/738 ,  C07C201/12 ,  C07C205/05 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/42 ,  C07C205/18 ,  C07C205/44 ,  C07C205/41 ,  C07C205/55

摘要： The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an α, β-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active α-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II).

公开(公告)号：EP2703381B1

公开(公告)日：2015-10-21

申请号：EP12777023.8

申请日：2012-04-27

申请人： Ono Pharmaceutical Co., Ltd.

发明人： HAYASHI, Yujiro

IPC分类号： C07C205/18 ,  C07C201/12 ,  C07C205/44 ,  C07D307/42 ,  C07B53/00 ,  C07B61/00

CPC分类号： C07D307/45 ,  C07B53/00 ,  C07C67/30 ,  C07C69/732 ,  C07C69/738 ,  C07C201/12 ,  C07C205/05 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/42 ,  C07C205/18 ,  C07C205/44 ,  C07C205/41 ,  C07C205/55

公开(公告)号：EP2703381A4

公开(公告)日：2014-10-08

申请号：EP12777023

申请日：2012-04-27

申请人： ONO PHARMACEUTICAL CO

发明人： HAYASHI YUJIRO

IPC分类号： C07C205/18 ,  C07B53/00 ,  C07B61/00 ,  C07C201/12 ,  C07C205/44 ,  C07D307/42

CPC分类号： C07D307/45 ,  C07B53/00 ,  C07C67/30 ,  C07C69/732 ,  C07C69/738 ,  C07C201/12 ,  C07C205/05 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/42 ,  C07C205/18 ,  C07C205/44 ,  C07C205/41 ,  C07C205/55