公开(公告)号：EP1122259A3

公开(公告)日：2001-10-31

申请号：EP01670001.5

申请日：2001-02-02

申请人： Labor Qualitas

发明人： Staack Reis Machado, Ana Maria ,  De Magalhäes Nunes Da Ponte, Manuel Luis ,  Alves Casimiro, Teresa Maria ,  Alves Ribeiro, Nuno Rui

IPC分类号： C07G17/00 ,  A61K31/045 ,  A61K35/78

CPC分类号： C07G5/00 ,  Y02P20/544

摘要： Extraction process wherein a supercritical fluid, or the same fluid in liquid state under near critical conditions, is used to extract the ceroid fraction of cork smoker wash solids and to isolate (C 20 - C 26 ) long chain aliphatic alcohols, diterpenoid and triterpenoid compounds contained in said fraction. The extracts containing diterpenes, triterpenoids, long chain aliphatic alcohols, or mixtures thermos enriched in these compounds are submitted to fractionation, these compounds being isolated from the extracts. Extraction may be carried out in a batch or semi-batch mode at temperatures between 30°C and 100°C, the preferred temperature range being between 30°C and 50°C and at pressures between 6 MPa and 40 MPa (60 bar and 400 bar). Pressure and temperature may be changed during the extraction, or may be kept constant. The separation is carried out at temperatures between 20°C - 120°C and at pressures between 40 MPa (400 bar) and the atmospheric pressure. The fractionation may be carried out using separators, or in a column.

公开(公告)号：EP0573260A1

公开(公告)日：1993-12-08

申请号：EP93304246.7

申请日：1993-06-01

申请人： INDENA S.p.A.

发明人： Bombardelli, Ezio

IPC分类号： C07D519/04 ,  C07G5/00 ,  C07F9/10 ,  A61K7/48 ,  A61K31/33 ,  C07D461/00 ,  C07D491/22 ,  C07D457/02

CPC分类号： C07D461/00 ,  C07D457/02 ,  C07D519/04 ,  C07F9/106 ,  C07G5/00

摘要： Salts of a pharmacologically active, naturally occurring or synthetic alkaloids, or alkaloid derivatives and a phosphatidic acid are provided, which preferably have the formula

wherein

Alk represents a cation derived from said pharmacologically active, naturally occurring or synthetic alkaloid, or alkaloid derivative,
PA represents a phosphatidic acid or a mixture of different phosphatidic acids, and
x:y is from 2:1 to 1:2.

The therapeutic use of the salts of the invention inthe treatment of syndromes affecting the elderly, particularly conditions that are related to changes in cerebral metabolism and reduced blood flow are decribed, as well as cosmetic methods.

摘要翻译： 设置有药理学活性的，天然存在的或合成的生物碱，或生物碱衍生物和磷脂酸的盐，其优选具有下式 worin ALK darstellt从所述衍生的药理学活性的，天然存在的阳离子的或合成的生物碱，或生物碱衍生物 ，PA darstellt磷脂酸或不同的磷脂酸，且x的混合物：y为2：1至1：2。 在矿井治疗综合征的影响老年人的治疗用途本发明的盐，特别是条件也都涉及到被描述下，在脑代谢和血流量减少的变化，以及化妆品的方法。

公开(公告)号：EP2292629A1

公开(公告)日：2011-03-09

申请号：EP10009175.0

申请日：2010-09-03

申请人： Kallimopoulos, Thomas, Dr.

发明人： Kallimopoulos, Thomas, Dr.

IPC分类号： C07G5/00 ,  C07D471/18 ,  A61K31/439 ,  A61P43/00

CPC分类号： C07G5/00 ,  C07D471/18

摘要： The present invention concerns a method for extracting cytisine from biomaterial wherein the biomaterial is contacted with an alkaline aqueous solution, but in the absence of any other co-solvent such as an organic phase. Cytisine is recovered from the alkaline aqueous extract by extraction of the extract with rapeseed oil which in turn is extracted with an acidic aqueous phase.

摘要翻译： 本发明涉及从生物材料中提取洋甘菊的方法，其中生物材料与碱性水溶液接触，但不存在任何其它共溶剂如有机相。 通过用菜籽油萃取提取物，从碱性水提取物中回收洋葱，其又用酸性水相萃取。

公开(公告)号：EP0573260B1

公开(公告)日：2000-05-10

申请号：EP93304246.7

申请日：1993-06-01

申请人： INDENA S.p.A.

发明人： Bombardelli, Ezio

IPC分类号： C07D519/04 ,  C07G5/00 ,  C07F9/10 ,  A61K7/48 ,  A61K31/33 ,  C07D461/00 ,  C07D491/22 ,  C07D457/02

CPC分类号： C07D461/00 ,  C07D457/02 ,  C07D519/04 ,  C07F9/106 ,  C07G5/00

公开(公告)号：EP1122259A2

公开(公告)日：2001-08-08

申请号：EP01670001.5

申请日：2001-02-02

申请人： Labor Qualitas

发明人： Staack Reis Machado, Ana Maria ,  De Magalhäes Nunes Da Ponte, Manuel Luis ,  Alves Casimiro, Teresa Maria ,  Alves Ribeiro, Nuno Rui

IPC分类号： C07G5/00

CPC分类号： C07G5/00 ,  Y02P20/544

摘要： Extraction process wherein a supercritical fluid, or the same fluid in liquid state under near critical conditions, is used to extract the ceroid fraction of cork smoker wash solids and to isolate (C 20 - C 26 ) long chain aliphatic alcohols, diterpenoid and triterpenoid compounds contained in said fraction.
The extracts containing diterpenes, triterpenoids, long chain aliphatic alcohols, or mixtures thermos enriched in these compounds are submitted to fractionation, these compounds being isolated from the extracts.
Extraction may be carried out in a batch or semi-batch mode at temperatures between 30°C and 100°C, the preferred temperature range being between 30°C and 50°C and at pressures between 6 MPa and 40 MPa (60 bar and 400 bar). Pressure and temperature may be changed during the extraction, or may be kept constant.
The separation is carried out at temperatures between 20°C - 120°C and at pressures between 40 MPa (400 bar) and the atmospheric pressure. The fractionation may be carried out using separators, or in a column.

摘要翻译： 提取过程worin超临界流体，或液体状态下近临界条件相同的流体，用于提取软木吸烟者的蜡样质馏分洗固体和以分离（C20 C26）长链脂族醇，二萜和三萜化合物包含在 说分数。 含二萜，三萜类化合物，长链脂肪醇，或它们的混合物在保温瓶合成化合物富集的提取液进行分馏，正在从提取物中分离合成的化合物。 萃取可在间歇或半间歇方式在温度30℃和100℃，优选的温度范围在30℃和50℃之间，并在6兆帕和40兆帕（60巴之间的压力为之间执行 400条）。 压力和温度也可以在提取过程中可以改变，或者可以保持恒定。 120℃，在40MPa（400巴）和大气压力之间的压力 - 的分离是在20℃的温度下进行。 分馏可以使用分离器来进行，或者在一列中。

公开(公告)号：EP0379623A1

公开(公告)日：1990-08-01

申请号：EP89101427.6

申请日：1989-01-27

申请人： VIPONT PHARMACEUTICAL, INC.

发明人： Boulware, Richard ,  Schlowsky, George

IPC分类号： C07D491/14 ,  C07D491/04 ,  C07D221/18

CPC分类号： C07D491/14 ,  C07G5/00

摘要： A method for extracting valuable alkaloid mate­rials from plants containing the same comprising slurrying the comminuted plant material in a mixture of water and a cosolvent at a pH of 8.5, adding a nonpolar, water-insoluble, solvent to dissolve the alkaloid, washing the nonpolar phase with acidulated water to convert the alkaloid to the imminium ion or acid salt form, precipitating the alkaloid, and recovering and drying the alkaloid.

摘要翻译： 一种从含有该植物材料的植物中提取有价值的生物碱材料的方法，包括将粉碎的植物材料在水和助溶剂的混合物中于8.5的pH下混合，加入非极性的非水溶性溶剂以溶解生物碱，洗涤非极性相 用酸化水将生物碱转化为离子或酸盐形式，沉淀生物碱，回收和干燥生物碱。