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公开(公告)号：EP1222927B1
公开(公告)日：2013-11-20
申请号：EP02004100.0
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
IPC分类号： A61K36/27 , A61K31/704 , A61K31/78 , A23L1/30 , C07J41/00 , A61K31/57 , A61K31/58 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J17/00 , C07J7/00 , C07J15/00
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
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2.发明公开Pharmaceutical compositions having appetite suppressant activity 失效Verbindungen und Pharmazeutische Zusammensetzungen mitappetitunterdrückenderAktivität
公开(公告)号：EP1213020A2
公开(公告)日：2002-06-12
申请号：EP02004101.8
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fannie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： The present invention relates to a surface cutting apparatus for hot-rolled steel products for cutting the top and bottom surfaces of a hot-rolled steel product continuously or intermittently by passing said steel product between a pair of rotary drums (38a,38b) rotating in the direction reverse to each other, said apparatus having a disk (39a,39b) for recognizing a gap between the rotary drums (38a,38b), which has a diameter larger than that of said rotary drum, at both ends or one end of at least one rotary drum (38a,38b).
摘要翻译： 药物组合物含有可从含有具有式（1）的食欲抑制剂的Trichocaulon或Hoodia属植物获得的提取物。 还提供了获得提取物的方法和合成化合物（1）的方法及其类似物和衍生物。 本发明还涉及这种提取物和化合物（1）及其类似物用于制造具有食欲抑制活性的药物的用途。 本发明还提供了用于合成化合物（1）的新型中间体。
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公开(公告)号：EP0973534A1
公开(公告)日：2000-01-26
申请号：EP98917372.9
申请日：1998-04-15
申请人： CSIR
发明人： VAN HEERDEN, Fanie, Retief , VLEGGAAR, Robert , HORAK, Roelof, Marthinus , LEARMONTH, Robin, Alec , MAHARAJ, Vinesh , WHITTAL, Rory, Desmond
IPC分类号： A61K35/78
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).
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公开(公告)号：EP1598054A3
公开(公告)日：2009-06-10
申请号：EP05017768.2
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： A non-therapeutic method of suppressing appetite in a human or animal comprises administering to the said human or animal a composition, for example a foodstuff or beverage, comprising an extract from a plant of the genus Trichocaulon or the genus Hoodia, which extract contains an effective amount of an appetite-suppressant steroidal glycoside from said plant, wherein the steroidal glycoside has the formula
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公开(公告)号：EP1598054A2
公开(公告)日：2005-11-23
申请号：EP05017768.2
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： A non-therapeutic method of suppressing appetite in a human or animal comprises administering to the said human or animal a composition, for example a foodstuff or beverage, comprising an extract from a plant of the genus Trichocaulon or the genus Hoodia, which extract contains an effective amount of an appetite-suppressant steroidal glycoside from said plant, wherein the steroidal glycoside has the formula
摘要翻译： 抑制人或动物食欲的非治疗方法包括向所述人或动物施用包含来自Trichocaulon属或Hoodia属植物的提取物的组合物，例如食品或饮料，该提取物含有 有效量的来自所述植物的食欲抑制甾体糖苷，其中所述甾体糖苷具有下式
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公开(公告)号：EP0973534B1
公开(公告)日：2006-11-02
申请号：EP98917372.9
申请日：1998-04-15
申请人： CSIR
发明人： VAN HEERDEN, Fanie, Retief , VLEGGAAR, Robert , HORAK, Roelof, Marthinus , LEARMONTH, Robin, Alec , MAHARAJ, Vinesh , WHITTAL, Rory, Desmond
IPC分类号： A61K36/27
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).
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公开(公告)号：EP1213020A3
公开(公告)日：2005-03-09
申请号：EP02004101.8
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： The present invention relates to a surface cutting apparatus for hot-rolled steel products for cutting the top and bottom surfaces of a hot-rolled steel product continuously or intermittently by passing said steel product between a pair of rotary drums (38a,38b) rotating in the direction reverse to each other, said apparatus having a disk (39a,39b) for recognizing a gap between the rotary drums (38a,38b), which has a diameter larger than that of said rotary drum, at both ends or one end of at least one rotary drum (38a,38b).
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8.发明公开Use of extracts from Hoodia gordonii and Hoodia lugardii for the preparation of a medicament for use in the suppression of appetite 失效戈登使用仙人掌或仙人掌lugardii的提取物在制备用于治疗食欲抑制
公开(公告)号：EP1438965A1
公开(公告)日：2004-07-21
申请号：EP04002070.3
申请日：1998-04-15
申请人： CSIR
发明人： van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
摘要： Extracts obtainable from Hoodia gordonii or lugardii containing an appetite suppressant agent having the formula (1) are disclosed for the manufacture of medicaments having appetite suppressant activity.
摘要翻译： 从提取物的Hoodia可获得的戈登或lugardii含有通式（1）的光盘为游离缺失具有食欲抑制活性的药物的制造中的食欲抑制剂剂。
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公开(公告)号：EP1598054B1
公开(公告)日：2011-03-16
申请号：EP05017768.2
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
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10.发明授权Compounds and pharmaceutical compositions having appetite suppressant activity 失效具有食欲抑制活性的化合物和药物组合物
公开(公告)号：EP1213020B1
公开(公告)日：2009-02-11
申请号：EP02004101.8
申请日：1998-04-15
申请人： CSIR
发明人： Van Heerden, Fanie Retief , Vleggaar, Robert , Horak, Roelof Marthinus , Learmonth, Robin Alec , Maharaj, Vinesh , Whittal, Rory Desmond
CPC分类号： A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
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