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11 条记录 (耗时 0.017 秒)

    Physiologically active compositions
    2.
    发明公开
    Physiologically active compositions 失效
    生理活性成分

    公开(公告)号：EP0137234A3

    公开(公告)日：1987-08-19

    申请号：EP84109773

    申请日：1984-08-16

    申请人： THE WELLCOME FOUNDATION LIMITED

    发明人： Aston, Roger ,  Holder, Andrew Thomas ,  Ivanyi, Juraj

    IPC分类号： A61K39/395 ,  A61K37/24 ,  A61K39/00 ,  C12P21/00 ,  C12N15/00

    CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  C07K14/615

    摘要： It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. However antibodies in vivo were believed to have the opposite effect. It has now been found that the administration to vertebrates of certain specific anti-hormone antibodies, preferably monoclonal antibodies, with or without administration of the hormone itself, can potentiate the biological action of the hormone. Active immunisation with a fragment of the hormone can also be carried out. Such methods can be used therapeutically or alternatively to increase the response of the vertebrate to the hormone beyond normal physiological levels. When the hormone is growth hormone, accelerated growth of economically important animals can be achieved.

    PHENAZINE AND QUINOXALINE SUBSTITUTED AMINO ACIDS AND POLYPEPTIDES
    3.
    发明公开
    PHENAZINE AND QUINOXALINE SUBSTITUTED AMINO ACIDS AND POLYPEPTIDES 审中-公开
    吩嗪和CHINOXALINSUBSTITUIERTE氨基和多肽

    公开(公告)号：EP2076500A1

    公开(公告)日：2009-07-08

    申请号：EP07866111.3

    申请日：2007-12-28

    申请人： Ambrx, Inc.

    发明人： MIAO, Zhenwei

    IPC分类号： C07D241/40 ,  C07D401/14 ,  C07D487/12

    CPC分类号： C07K1/1075 ,  C07D241/40 ,  C07D401/14 ,  C07D487/12 ,  C07K14/615

    摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a phenazine or quinoxaline substituent. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides.

    PRODUCTION OF PEPTIDES BY FEDBATCH CULTIVATION OF A MICROORGANISM
    4.
    发明公开
    PRODUCTION OF PEPTIDES BY FEDBATCH CULTIVATION OF A MICROORGANISM 审中-公开
    PRODUCTION BY肽的微生物的补料分批培养

    公开(公告)号：EP1244769A1

    公开(公告)日：2002-10-02

    申请号：EP00982029.1

    申请日：2000-11-29

    申请人： Pharmacia AB

    发明人： CASTAN, Andreas

    IPC分类号： C12M1/00 ,  C12P21/00 ,  C12N1/00

    CPC分类号： C12P21/02 ,  C07K14/615

    摘要： The invention relates to a method for the production of recombinant peptides by fedbatch cultivation of a microorganism in a bioreactor containing a medium comprising organic carbon source, nitrogen source and mineral salts. The cultivation is carried out by the addition of the organic carbon source by oscillation feed and/or by oscillation variation of stirring speed, e.g. in a square or sinus wave pattern. Preferably the organic carbon source is glucose and the recombinant peptide is growth hormone.

    Process for producing human growth hormone
    6.
    发明公开
    Process for producing human growth hormone 失效
    Verfahren zur Erzeugung des menschlichen Wachstumhormons。

    公开(公告)号：EP0219295A2

    公开(公告)日：1987-04-22

    申请号：EP86307707.9

    申请日：1986-10-06

    申请人： NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JCR PHARMACEUTICALS CO., LTD

    发明人： Hiratani, Hajime ,  Tateishi, Jun ,  Kitamoto, Tetsuyuki

    IPC分类号： C07K3/26

    CPC分类号： C07K14/615 ,  A61K38/00 ,  A61K38/27 ,  A61L2/0017 ,  A61L2/022

    摘要： A membrane filter of 0.025 to 0.05 µm pore size is previously treated by passing a solution of a water-soluble high molecular substance such as albumin, dextran,polyvinylpyrrolidone, poly­ethyleneglycol, gelatin or the like through the filter. Employ­ing the filter thus treated, a solution of human growth hormone (HGH) is filtered at high recovery rate of HGH activity to remove Creutzfeldt-Jacob disease pathogen which may exist in HGH pre­parations.

    摘要翻译： 预先通过使白蛋白，葡聚糖，聚乙烯吡咯烷酮，聚乙二醇，明胶等水溶性高分子物质的溶液通过过滤器来处理孔径为0.025〜0.05μm的膜过滤器。 使用如此处理的过滤器，以高回收率的HGH活性过滤人生长激素（HGH）的溶液以除去可能存在于HGH制剂中的Creutzfeldt-Jacob病病原体。