公开(公告)号：EP2060588A4

公开(公告)日：2011-10-12

申请号：EP07806643

申请日：2007-09-04

申请人： DAICEL CHEM ,  UNIV NAGOYA NAT UNIV CORP

发明人： OKAMOTO YOSHIO ,  YAMAMOTO CHIYO ,  KONDO SHUNSUKE ,  KAMIGAITO MASAMI

IPC分类号： C08B33/06 ,  B01J20/29 ,  C07B57/00 ,  C08B33/00 ,  C08B33/02 ,  G01N30/88

CPC分类号： C08B33/02 ,  B01J20/262 ,  B01J20/265 ,  B01J20/285 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3272 ,  B01J20/328 ,  C07B57/00 ,  C08B33/00 ,  C08B33/04 ,  C08B33/06

公开(公告)号：EP1397162A2

公开(公告)日：2004-03-17

申请号：EP02762293.5

申请日：2002-06-19

申请人： Fresenius Kabi Deutschland GmbH

发明人： SOMMERMEYER, Klaus

IPC分类号： A61K47/48

CPC分类号： C08B35/06 ,  A61K47/61 ,  C08B31/00 ,  C08B31/04 ,  C08B31/08 ,  C08B31/125 ,  C08B31/16 ,  C08B33/00 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/00 ,  C08B35/02 ,  C08B35/04

摘要： The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. The cytostatic agents daunorubicin and doxorubicin are highly cardiotoxic. The novel pharmaceutical forms are antibiotic-starch conjugates, wherein the antibiotic is combined with the polysaccharide at the reducing end thereof by means of a peptide bond. According to the invention, said bond is carried out by means of J2-oxidation of the starch derivative at the reducing end thereof in an aqueous alkaline solution, and by coupling the starch derivative oxidised thereby to the antibiotic in an organic solution. The conjugates obtained are less toxic. The polysaccharide part can be decomposed by serum-α-amylase and the peptide bond can be accessed by an enzymatic attack.

公开(公告)号：EP2060588B1

公开(公告)日：2014-08-06

申请号：EP07806643.8

申请日：2007-09-04

申请人： Daicel Corporation ,  National University Corporation Nagoya University

发明人： OKAMOTO, Yoshio ,  YAMAMOTO, Chiyo ,  KONDO, Shunsuke ,  KAMIGAITO, Masami

IPC分类号： C08B33/06 ,  C07B57/00 ,  G01N30/88 ,  C08B33/00 ,  C08B33/02 ,  B01J20/29

CPC分类号： C08B33/02 ,  B01J20/262 ,  B01J20/265 ,  B01J20/285 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3272 ,  B01J20/328 ,  C07B57/00 ,  C08B33/00 ,  C08B33/04 ,  C08B33/06

公开(公告)号：EP2060588A1

公开(公告)日：2009-05-20

申请号：EP07806643.8

申请日：2007-09-04

申请人： Daicel Chemical Industries, Ltd. ,  National University Corporation Nagoya University

发明人： OKAMOTO, Yoshio ,  YAMAMOTO, Chiyo ,  KONDO, Shunsuke ,  KAMIGAITO, Masami

IPC分类号： C08B33/06 ,  C07B57/00 ,  G01N30/88

CPC分类号： C08B33/02 ,  B01J20/262 ,  B01J20/265 ,  B01J20/285 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3272 ,  B01J20/328 ,  C07B57/00 ,  C08B33/00 ,  C08B33/04 ,  C08B33/06

摘要： The present invention provides: a polysaccharide derivative containing a structure wherein hydrogen atoms in a hydroxyl group or amino group at the 2-position and the 3-position of a structure unit of polysaccharide are substituted with different substituents respectively represented by a specific general formula; and, a separating agent for optical isomers, which contains such a polysaccharide derivative. The present invention can provide a novel polysaccharide derivative which has excellent optical isomer separating ability, and is thus suitable for a separating agent for optical isomers, and can provide a separating agent for optical isomers which comprises the polysaccharide derivative.

摘要翻译： 本发明提供：含有分别用特定通式表示的不同取代基取代多糖结构单元的2-位和3-位的羟基或氨基的氢原子的结构的多糖衍生物， 以及含有这样的多糖衍生物的光学异构体用分离剂。 本发明可以提供具有优异的旋光异构体分离能力的新型多糖衍生物，因此适用于光学异构体的分离剂，并且可以提供包含多糖衍生物的旋光异构体分离剂。