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    UNIVERSAL DONOR CELLS
    2.
    发明公开
    UNIVERSAL DONOR CELLS 审中-公开

    公开(公告)号：EP4435093A2

    公开(公告)日：2024-09-25

    申请号：EP24176526.2

    申请日：2019-09-07

    申请人： CRISPR Therapeutics AG

    发明人： REZANIA, Alireza ,  HO, Tony W. ,  RAMOS-ZAYAS, Rebeca

    IPC分类号： C12N5/074

    CPC分类号： C12N5/0606 ,  C12N5/0696 ,  C12N2310/2020170501 ,  C12N2501/5020130101 ,  C12N2510/0020130101 ,  C07K14/70539

    摘要： Genetically modified cells that are compatible with multiple subjects, e.g., universal donor cells, and methods of generating said genetic modified cells are provided herein. The universal donor cells comprise at least one genetic modification within or near at least one gene that encodes one or more MHC-I or MHC-II human leukocyte antigens or component or transcriptional regulator of the MHC-I or MHC-II complex, at least one genetic modification that increases the expression of at least one polynucleotide that encodes a tolerogenic factor, and optionally at least one genetic modification that increases or decreases the expression of at least one gene that encodes a survival factor.